Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Dean, Bottino"'
Autor:
Yuki Otani, Yunqi Zhao, Guanyu Wang, Richard Labotka, Mark Rogge, Neeraj Gupta, Majid Vakilynejad, Dean Bottino, Yusuke Tanigawara
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 12, Pp 2124-2136 (2024)
Abstract Multiple myeloma (MM) treatment guidelines recommend waiting for formal progression criteria (FPC) to be met before proceeding to the next line of therapy. As predicting progression may allow early switching to next‐line therapy while the
Externí odkaz:
https://doaj.org/article/862531faf736495183488735ded1aa0e
Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategy
Autor:
Madison Stoddard, Lin Yuan, Sharanya Sarkar, Shruthi Mangalaganesh, Ryan P. Nolan, Dean Bottino, Greg Hather, Natasha S. Hochberg, Laura F. White, Arijit Chakravarty
Publikováno v:
Vaccines, Vol 11, Iss 4, p 806 (2023)
SARS-CoV-2 vaccinations were initially shown to substantially reduce risk of severe disease and death. However, pharmacokinetic (PK) waning and rapid viral evolution degrade neutralizing antibody (nAb) binding titers, causing loss of vaccinal protect
Externí odkaz:
https://doaj.org/article/96a245fc87ee4429b1fd2755184c4612
Autor:
Anna Kondic, Dean Bottino, John Harrold, Jeffrey D. Kearns, CJ Musante, Aleksandrs Odinecs, Saroja Ramanujan, Jangir Selimkhanov, Birgit Schoeberl
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided
Externí odkaz:
https://doaj.org/article/cc2e644a24a548b9a118216b30197d39
Autor:
Ana Ruiz-Garcia, Paul Baverel, Dean Bottino, Michael Dolton, Yan Feng, Ignacio González-García, Jaeyeon Kim, Seth Robey, Indrajeet Singh, David Turner, Shu-Pei Wu, Donghua Yin, Di Zhou, Hao Zhu, Peter Bonate
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 50:147-172
Exposure–response (E–R) analyses are an integral component in the development of oncology products. Characterizing the relationship between drug exposure metrics and response allows the sponsor to use modeling and simulation to address both inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::930dfc175ba48c8b30148ee26bbd619d
https://doi.org/10.1007/s10928-023-09850-2
https://doi.org/10.1007/s10928-023-09850-2
Autor:
Cheryl Li, Lei Shen, Sabrina Collins, Adarsh Joshi, Subhasree Das, Kaveri Suryanarayan, Dean Bottino, Michael Curley, Dannie Wang, Michael Abadier, Ryan Larson, Xavier Parot
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/0095415875fa461a8b86d9a4ab31a7f7
Autor:
Tomas Radivoyevitch, Brian J. Druker, Jerry Radich, Hagop Kantarjian, Wenlong Tang, Michael J. Hanley, Mingxi M. Song, Timothy Smith, Dean Bottino
Publikováno v:
Blood. 140:6793-6795
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9889d7b05d9beea9176515ef0538d43f
https://doi.org/10.1182/blood-2022-159194
https://doi.org/10.1182/blood-2022-159194
Autor:
Andreas Hochhaus, Jerald P. Radich, Timothy P. Hughes, John M. Goldman, Jaspal Kaeda, Susan Branford, Vijay Modur, Dean Bottino, Andrew M. Stein
Purpose: Imatinib induces a durable response in most patients with Philadelphia chromosome–positive chronic myeloid leukemia, but it is currently unclear whether imatinib reduces the leukemic stem cell (LSC) burden, which may be an important step t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818ca19e251e937b8a9b69d9a84312dd
https://doi.org/10.1158/1078-0432.c.6519950
https://doi.org/10.1158/1078-0432.c.6519950
Autor:
Andreas Hochhaus, Jerald P. Radich, Timothy P. Hughes, John M. Goldman, Jaspal Kaeda, Susan Branford, Vijay Modur, Dean Bottino, Andrew M. Stein
PDF file - 325K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388de08ff36825f3b25d05b8488ec863
https://doi.org/10.1158/1078-0432.22443761.v1
https://doi.org/10.1158/1078-0432.22443761.v1
Autor:
Andreas Hochhaus, Jerald P. Radich, Timothy P. Hughes, John M. Goldman, Jaspal Kaeda, Susan Branford, Vijay Modur, Dean Bottino, Andrew M. Stein
CCR Translation for This Article from BCR–ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c686a8e96f9ef7e9973c42b060e9768
https://doi.org/10.1158/1078-0432.22443764.v1
https://doi.org/10.1158/1078-0432.22443764.v1
Autor:
Glenwood D. Goss, Mark DeMario, Ka Wang, David Geho, Tiantom Jarutat, Suzana M. Vega-Harring, Markus Roessler, Hua Zhong, Dean Bottino, Kathleen J. Schostack, Mary E. Simcox, Aaron R. Hansen, Derek J. Jonker, Jan H.M. Schellens, Morten Mau-Sorensen, Vaios Karanikas, Lilian L. Siu, Didier Meulendijks, Ulrik N. Lassen
Supplemental Figure S1 and Table S1. Figure S1: RG7212 phase I study flow diagram and treatment schema. Table S1. Summary of Fn14 Testing and Positivity Rate (IHC{greater than or equal to}1+) for the Most Commonly Screened Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0ab408c3772903e1549f808a8c8771
https://doi.org/10.1158/1078-0432.22460889.v1
https://doi.org/10.1158/1078-0432.22460889.v1