Zobrazeno 1 - 10
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pro vyhledávání: '"Deal Judith G"'
Akademický článek
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Autor:
Chengyi Zhang, Sujin Cho-Schultz, Tran Khanh Tuan, Manli Shi, Rose Ann Ferre, Sherry Niessen, Sajiv Krishnan Nair, Douglas Carl Behenna, Dac M. Dinh, Elaine E. Tseng, Theodore O. Johnson, Cheng Hengmiao, Ru Zhou, Michael Zientek, T. Eric Ballard, Brion W. Murray, Suvi T. M. Orr, James Solowiej, Jennifer Lafontaine, Jean Joo Matthews, Scott L. Weinrich, Paolo Vicini, Deal Judith G, Longqing Liu, John Charles Kath, Pairish Mason Alan, Simon Paul Planken, Louise Bernier, Deepak Dalvie, Yiqin Luo, Martin Paul Edwards, Asako Nagata, Hong Shen, Neal W. Sach, Yuli Wang, Ketan S. Gajiwala, Shuibo Xin, Simon Bailey, Chau Almaden, Robert Steven Kania, Michelle Hemkens
Publikováno v:
Journal of Medicinal Chemistry. 60:3002-3019
Mutant epidermal growth factor receptor (EGFR) is a major driver of non-small-cell lung cancer (NSCLC). Marketed first generation inhibitors, such as erlotinib, effect a transient beneficial response in EGFR mutant NSCLC patients before resistance me
Autor:
Cheng, Hengmiao, Orr, Suvi T. M., Bailey, Simon, Brooun, Alexei, Chen, Ping, Deal, Judith G., Deng, Yali L., Edwards, Martin P., Gallego, Gary M., Grodsky, Neil, Huang, Buwen, Jalaie, Mehran, Kaiser, Stephen, Kania, Robert S., Kephart, Susan E., Lafontaine, Jennifer, Ornelas, Martha A., Pairish, Mason, Planken, Simon, Shen, Hong
Publikováno v:
Journal of Medicinal Chemistry; 1/14/2021, Vol. 64 Issue 1, p644-661, 18p
Autor:
Sergei Timofeevski, Lars D. Engstrom, Mingying He, Michael R. Collins, Martin Paul Edwards, Phuong Le, Graham L. Smith, John Charles Kath, Helen Y. Zou, Deal Judith G, Ya-Li Deng, Robert Steven Kania, Benjamin J. Burke, Cynthia Louise Palmer, Huichun Zhu, A.E. Stewart, Hieu Lam, Dac M. Dinh, Simon Bailey, Jacqui Elizabeth Hoffman, Neal W. Sach, Robert Louis Hoffman, Qinhua Huang, J. Jean Cui, Alexei Brooun, Wei Liu, Laura Lingardo, Tod Smeal, Ted William Johnson, Michele McTigue, Justine L. Lam, Jinjiang Zhu, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 57:4720-4744
Although crizotinib demonstrates robust efficacy in anaplastic lymphoma kinase (ALK)-positive non-small-cell lung carcinoma patients, progression during treatment eventually develops. Resistant patient samples revealed a variety of point mutations in
Autor:
Tod Smeal, Wei Liu, Huichun Zhu, Simon Bailey, Michael R. Collins, A.E. Stewart, Jacqui Elizabeth Hoffman, Lars D. Engstrom, Graham L. Smith, J. Jean Cui, Ya-Li Deng, Benjamin J. Burke, Laura Lingardo, Phuong Le, Andrew Simon Cook, Konstantinos Tsaparikos, Hieu Lam, Jinjiang Zhu, Ted William Johnson, Neal W. Sach, Dac M. Dinh, Robert Louis Hoffman, Mingying He, Hui Wang, Alexei Brooun, Dack Kevin Neil, Qinhua Huang, Sergei Timofeevski, Deal Judith G, Justine L. Lam, Qiuhua Li, Hong Shen, Melissa West Lu, Michele McTigue, Paul F. Richardson, Kevin D. Bunker, Robert Steven Kania, Martin Paul Edwards, Helen Y. Zou, Cynthia Louise Palmer, Patrick S. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 57:1170-1187
Crizotinib (1), an anaplastic lymphoma kinase (ALK) receptor tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration in 2011, is efficacious in ALK and ROS positive patients. Under pressure of crizotinib treatment, point mutations
Autor:
Kephart Susan Elizabeth, Annette John-Baptiste, Deal Judith G, Danlin Gu, Shubha Bagrodia, Cui Jingrong Jean, Shinji Yamazaki, Djamal Bouzida, Pairish Mason Alan, Evan Smith, Chuangxing Guo, Robert Steven Kania, Dong Liming, Angelica Linton, Indrawan James Mcalpine, Cynthia Louise Palmer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7605-7609
( S )-1-((4-(3-(6-Amino-5-methoxypyridin-3-yl)-1-isopropyl-1 H -pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-ol, 1 , was recently identified as a potent inhibitor of the oncogenic kinase bRAF. Compounds containing 3-methoxy-2-aminopyridine, as in 1 , c
Autor:
Dong Liming, Xinjun Hou, Elizabeth A. Lunney, Corinne E. Augelli-Szafran, Deal Judith G, Christopher F. Bigge, Darin Vanderpool, Raymond Andrew Hudack, Nancy Sue Barta, Bradley William Caprathe, Chuangxing Guo, Steve Bender, Richard E. Showalter, Lorraine Kathleen Fay, Arindam Chatterjee
Publikováno v:
Journal of Medicinal Chemistry. 49:1202-1206
Since the discovery that FK-506 promotes neurite outgrowth, considerable attention has been focused on the development of potent nonimmunosuppressive ligands for FK-506 binding proteins (FKBPs). Such neuroimmunophilin agents have been reported to sho
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Varney Michael D, Charlotte A. Bartlett, Stephanie Webber, Catharine A. Morse, Ward W. Smith, Cheryl A. Janson, Cindy L. Palmer, Deal Judith G, Katherine M. Welsh
Publikováno v:
Journal of Medicinal Chemistry. 38:1892-1903
The design, synthesis, and biochemical and biological evaluations of a novel series of 2,6-diaminobenz[cd]indole-containing inhibitors of human thymidylate synthase (TS) are described. The compounds are characterized by having either a pyridine or py
Autor:
C. A. Morse, Deal Judith G, Marzoni Gifford P, Russell J. Bacquet, Varney Michael D, Katherine M. Welsh, Cynthia Louise Palmer, Carol L. J. Booth, Charlotte A. Bartlett, Stephanie Webber
Publikováno v:
Journal of Medicinal Chemistry. 35:663-676
The X-ray crystal-structure-based design, synthesis, and biological activity of a novel family of benz[cd]indole-containing inhibitors of thymidylate synthase (TS) are described. The structure-activity of the lead compound was studied by conceptually