Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Deacetylcolchicine"'
Publikováno v:
Iranian Journal of Pharmaceutical Research : IJPR
Colchicine as a vascular disrupting agent creates microtubule destabilization which induces vessel blockage and consequently cell death. Accordingly, colchicines and its analogues radiolabeled with 99mTc may have potential for visualization of tumor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1c0a4f1a3b8ef70ff6c9232d92b05ab
http://europepmc.org/articles/PMC5610754
http://europepmc.org/articles/PMC5610754
Autor:
G. S. Shekhawat, Sonali Jana
Publikováno v:
Fitoterapia. 82:293-301
Gloriosa superba L. is a perennial climber and is used as an ayurvedic medicinal herb to cure diseases in various parts of Africa and Southeast Asia. The plant was under threatened category due to its imprudent harvesting from wild as it is extensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d8266f2325ce67ea5d5f6e5cdea4ad
https://doi.org/10.1016/j.fitote.2010.11.008
https://doi.org/10.1016/j.fitote.2010.11.008
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 288:635-639
This work reports the synthesis, radiolabeling and preliminary biodistribution results in tumor-bearing mice of the 99mTc(CO)3–AOPA colchicine conjugate. The novel ligand was successfully synthesized by conjugation of N-(acetyloxy)-2-picolylamino (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15fab1581ab50f042608e1d7cd7f475e
https://doi.org/10.1007/s10967-011-0983-4
https://doi.org/10.1007/s10967-011-0983-4
Akademický článek
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Publikováno v:
ChemInform. 28
The synthesis of deacetylcolchicine from colchicine is described with an overall yield of 83%. The transformation does not involve the classical tropone ring isomerization known with these products and resulting from the hydrolysis of the acetamide i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96974418c6132ebce1c358967f0c7af9
https://doi.org/10.1002/chin.199724233
https://doi.org/10.1002/chin.199724233
Autor:
Ezio Bombardelli, Davide Prosperi, Daniele Passarella, Riccardo Destro, Giordano Lesma, Emanuela May, Alessandro Sacchetti, Alessandra Silvani, Bruno Danieli
Publikováno v:
Helvetica chimica acta 86 (2003): 2082–2089.
info:cnr-pdr/source/autori:Danieli B., Lesma G., Passarella D., Prosperi D., Sacchetti A., Silvani A., Destro R., May E., Bombardelli E./titolo:New Tetracyclic Colchicinoids from the Reaction of N-Deacetylthiocolchicine and N-Deacetylcolchicine with Nitrous Acid and tert-Butyl Nitrite/doi:/rivista:Helvetica chimica acta/anno:2003/pagina_da:2082/pagina_a:2089/intervallo_pagine:2082–2089/volume:86
info:cnr-pdr/source/autori:Danieli B., Lesma G., Passarella D., Prosperi D., Sacchetti A., Silvani A., Destro R., May E., Bombardelli E./titolo:New Tetracyclic Colchicinoids from the Reaction of N-Deacetylthiocolchicine and N-Deacetylcolchicine with Nitrous Acid and tert-Butyl Nitrite/doi:/rivista:Helvetica chimica acta/anno:2003/pagina_da:2082/pagina_a:2089/intervallo_pagine:2082–2089/volume:86
Reaction of N-deacetylthiocolchicine (3) and N-deacetylcolchicine (4) with nitrous acid (HONO) furnished the new tetracyclic colchicinoids 5 and 6, as well as the Demyanov-rearrangement products 7 and 8. Starting from 3, the pyrazole-containing tetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7045681d755f6de3c9a8bf04c2478fe5
https://publications.cnr.it/doc/47501
https://publications.cnr.it/doc/47501
Autor:
Arnold Brossi, Olivier Boyé
Publisher Summary This chapter discusses that practical synthesis of natural (aS, 7S)-colchicine and its 3-demethyl analog remain a challenge for organic chemists. Variation of the structure of colchicine has led to several possibly less toxic analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4bb6e41521b5cb290f50ee44778179
https://doi.org/10.1016/s0099-9598(08)60106-6
https://doi.org/10.1016/s0099-9598(08)60106-6
Publikováno v:
Journal of natural products. 53(4)
Two minor Colchicum alkaloids, N-acetoacetyl-deacetylcolchicine [1] and 2-demethylspeciosine [7], were synthesized. The diacetate 8 of 2-demethylspeciosine was also prepared. The antitubulin activity of these compounds, in comparison to colchicine, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28efbaaa0ab504231e87e51b1d0844f
https://pubmed.ncbi.nlm.nih.gov/2095370
https://pubmed.ncbi.nlm.nih.gov/2095370
Autor:
Von Euler H, Resegotti L
Publikováno v:
Zeitschrift f�r Krebsforschung. 61:125-132
Untersucht wurden Leber, Milz, Nieren sowie Ascites und fester Tumor von Yoshida-Ascitessarkomratten, welche mit D-Tartrat des Methylesters von Trimethyl-Colchicinsaure (DAC) injiziert wurden, zum Teil unter gleichzeitiger Injektion von Hydrocortison
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806ad4f03bb51b94ac7867e59366751f
https://doi.org/10.1007/bf00524329
https://doi.org/10.1007/bf00524329
Publikováno v:
Tumori Journal. 43:698-710
The action of some associations of cytostatic agents on « in vitro » embryonic cells are studied: chloramine, deacetylcolchicine and 6-mercapto-purine added with hydrocortisone, and 6-mercapto-purine plus chloramine. The effective doses of each dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb079dd25df68c88f9f188eed316cd2
https://doi.org/10.1177/030089165704300602
https://doi.org/10.1177/030089165704300602