TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Autor: Angelo L. Grauel, Beverly Nguyen, David Ruddy, Tyler Laszewski, Stephanie Schwartz, Jonathan Chang, Julie Chen, Michelle Piquet, Marc Pelletier, Zheng Yan, Nathaniel D. Kirkpatrick, Jincheng Wu, Antoine deWeck, Markus Riester, Matt Hims, Felipe Correa Geyer, Joel Wagner, Kenzie MacIsaac, James Deeds, Rohan Diwanji, Pushpa Jayaraman, Yenyen Yu, Quincey Simmons, Shaobu Weng, Alina Raza, Brian Minie, Mirek Dostalek, Pavitra Chikkegowda, Vera Ruda, Oleg Iartchouk, Naiyan Chen, Raphael Thierry, Joseph Zhou, Iulian Pruteanu-Malinici, Claire Fabre, Jeffrey A. Engelman, Glenn Dranoff, Viviana Cremasco

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibrob

Externí odkaz: https://doaj.org/article/55eb6b2ee746490ba919c1fb7bbcfb1d

A method to evaluate utility for architectural comparisons for a campaign to explore the surface of Mars

Autor: Ward, Eric D., Webb, Ryan R., deWeck, Olivier L.

Publikováno v: In Acta Astronautica November-December 2016 128:237-242

Supplementary Table S2 from CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Autor: Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz

Annotations for the sgRNA libraries containing sequences, target gene information, Zscore and RNAseq data for each cell line screened.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8168764e4a5b7839ac54b7f252bfc00d
https://doi.org/10.1158/2159-8290.22531560

Supplementary Figures S1 - S11 from CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Autor: Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz

Supplementary Figure S1. Comparison of drop out phenotypes in MKN45, RKO, HT1080 highlighting selected pan-lethal genes. Supplementary Figure S2. The genes that scored as lethal by both RNAi and CRISPR were strongly enriched for known essential genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b398466e1fca85bee6e1c3e61c9c3ad
https://doi.org/10.1158/2159-8290.22531566

Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens

Autor: Juan Diaz-Miyar, Antoine deWeck, Marc Altorfer, Guglielmo Roma, Annick Waldt, Fanny Mermet-Meillon, Ulrike Naumann, Rok Krese, Rachel Cuttat, Mathias Eder, Joachim Weischenfeldt, Rui Lopes, André Vidas Olsen, Simon Wengert, Walter Carbone, Esther C. H. Uijttewaal, Verena Apfel, Adriana Emma Wesdorp, Kathleen Sprouffske, Dirk Schübeler, Giorgio G. Galli, Audrey Kauffmann, Philipp S. Hoppe, Jan Dahinden, Melusine Bleu, Umut Yildiz, Judith Knehr, Caibin Sheng

Publikováno v: Lopes, R, Sprouffske, K, Sheng, C, Uijttewaal, E C H, Wesdorp, A E, Dahinden, J, Wengert, S, Diaz-Miyar, J, Yildiz, U, Bleu, M, Apfel, V, Mermet-Meillon, F, Krese, R, Eder, M, Olsen, A V, Hoppe, P, Knehr, J, Carbone, W, Cuttat, R, Waldt, A, Altorfer, M, Naumann, U, Weischenfeldt, J, deWeck, A, Kauffmann, A, Roma, G, Schübeler, D & Galli, G G 2021, ' Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens ', Science Advances, vol. 7, no. 27, eabf5733 . https://doi.org/10.1126/sciadv.abf5733

Millions of putative transcriptional regulatory elements (TREs) have been cataloged in the human genome, yet their functional relevance in specific pathophysiological settings remains to be determined. This is critical to understand how oncogenic tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d2f8984b1f3f9701761e7abc615195
https://curis.ku.dk/portal/da/publications/systematic-dissection-of-transcriptional-regulatory-networks-by-genomescale-and-singlecell-crispr-screens(22df3d06-0c32-449b-8fc4-303d9a1dae35).html