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Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells.

Autor: Jang HJ; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA., Shah NM; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Maeng JH; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Liang Y; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Basri NL; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Ge J; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Qu X; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Mahlokozera T; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA., Tzeng SC; Donald Danforth Plant Science Center, St. Louis, MO, USA., Williams RB; Donald Danforth Plant Science Center, St. Louis, MO, USA., Moore MJ; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Annamalai D; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA., Chen JY; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Lee HJ; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., DeSouza PA; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA., Li D; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Xing X; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA., Kim AH; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA. alberthkim@wustl.edu.; The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu., Wang T; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. twang@wustl.edu.; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA. twang@wustl.edu.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. twang@wustl.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Sep; Vol. 56 (9), pp. 1903-1913. Date of Electronic Publication: 2024 Sep 02.

Long, Noncoding RNA Dysregulation in Glioblastoma.

Autor: DeSouza PA; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Qu X; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Chen H; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Department of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Patel B; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Maher CA; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Kim AH; Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.

Publikováno v: Cancers [Cancers (Basel)] 2021 Mar 31; Vol. 13 (7). Date of Electronic Publication: 2021 Mar 31.

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

Autor: Allaway R; Sage Bionetworks, Seattle, WA, United States of America., Angus SP; University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Beauchamp RL; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Blakeley JO; Johns Hopkins University School of Medicine, Baltimore, MD, United States of America., Bott M; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, FL, United States of America., Burns SS; Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United States of America., Carlstedt A; Leibniz-Institute on Aging-Fritz-Lipmann Institute (FLI), Jena, Germany., Chang LS; Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United States of America., Chen X; University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Clapp DW; Indiana University, School of Medicine, Indianapolis, IN, United States of America., Desouza PA; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Erdin S; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Fernandez-Valle C; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, FL, United States of America., Guinney J; Sage Bionetworks, Seattle, WA, United States of America., Gusella JF; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Haggarty SJ; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Johnson GL; University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., La Rosa S; Children's Tumor Foundation, New York, NY, United States of America., Morrison H; Leibniz-Institute on Aging-Fritz-Lipmann Institute (FLI), Jena, Germany., Petrilli AM; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, FL, United States of America., Plotkin SR; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Pratap A; Sage Bionetworks, Seattle, WA, United States of America.; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, United States of America., Ramesh V; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Sciaky N; University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Stemmer-Rachamimov A; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Stuhlmiller TJ; University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Talkowski ME; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Welling DB; Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital and Harvard University, Boston, MA, United States of America., Yates CW; Indiana University, School of Medicine, Indianapolis, IN, United States of America., Zawistowski JS; University of North Carolina School of Medicine, Chapel Hill, NC, United States of America., Zhao WN; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.

Publikováno v: PloS one [PLoS One] 2018 Jun 13; Vol. 13 (6), pp. e0197350. Date of Electronic Publication: 2018 Jun 13 (Print Publication: 2018).