A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.

Autor: Guillen KP; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Fujita M; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Butterfield AJ; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Scherer SD; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Bailey MH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Chu Z; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., DeRose YS; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Zhao L; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Cortes-Sanchez E; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Yang CH; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Toner J; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Wang G; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Qiao Y; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Huang X; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Greenland JA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Vahrenkamp JM; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Lum DH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Factor RE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Nelson EW; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Matsen CB; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Poretta JM; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; 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Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA., Jones KB; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA., Li Z; Department of Pharmacology and Chemical Biology, University of Pittsburgh, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, PA, USA., Oesterreich S; Department of Pharmacology and Chemical Biology, University of Pittsburgh, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, PA, USA., Dobrolecki LE; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Pathi SS; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Woo XY; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Berrett KC; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Wadsworth ME; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UCONN-Health, Farmington, CT, USA., Lewis MT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Marth GT; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Gertz J; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Varley KE; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Welm BE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. bryan.welm@hci.utah.edu.; Department of Surgery, University of Utah, Salt Lake City, UT, USA. bryan.welm@hci.utah.edu., Welm AL; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA. alana.welm@hci.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. alana.welm@hci.utah.edu.

Publikováno v: Nature cancer [Nat Cancer] 2022 Feb; Vol. 3 (2), pp. 232-250. Date of Electronic Publication: 2022 Feb 24.

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.

Autor: Zoeller JJ; Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA., Vagodny A; Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA., Daniels VW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Taneja K; Department of Pathology, Brigham & Women's Hospital, Boston, MA, USA., Tan BY; Department of Pathology, Brigham & Women's Hospital, Boston, MA, USA., DeRose YS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Fujita M; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Welm AL; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Letai A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Leverson JD; Oncology Development, AbbVie, North Chicago, IL, USA., Blot V; Oncology Development, AbbVie, North Chicago, IL, USA., Bronson RT; Department of Pathology, Harvard Medical School, Boston, MA, USA., Dillon DA; Department of Pathology, Brigham & Women's Hospital, Boston, MA, USA., Brugge JS; Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA. joan_brugge@hms.harvard.edu.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2020 Nov 30; Vol. 22 (1), pp. 132. Date of Electronic Publication: 2020 Nov 30.

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.

Autor: Olsen SN; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Wronski A; Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts.; Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts., Castaño Z; Harvard Medical School, Boston, Massachusetts.; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Harvard Stem Cell Institute, Cambridge, Massachusetts., Dake B; Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts.; Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts., Malone C; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., De Raedt T; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Enos M; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., DeRose YS; Huntsman Cancer Institute, Salt Lake City, Utah., Zhou W; Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts.; Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts., Guerra S; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Loda M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Welm A; Huntsman Cancer Institute, Salt Lake City, Utah., Partridge AH; Harvard Medical School, Boston, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts., McAllister SS; Harvard Medical School, Boston, Massachusetts.; Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Harvard Stem Cell Institute, Cambridge, Massachusetts., Kuperwasser C; Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts.; Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts., Cichowski K; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. kcichowski@rics.bwh.harvard.edu.; Harvard Medical School, Boston, Massachusetts.; Huntsman Cancer Institute, Salt Lake City, Utah.

Publikováno v: Cancer discovery [Cancer Discov] 2017 Feb; Vol. 7 (2), pp. 202-217. Date of Electronic Publication: 2016 Dec 14.

Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine.

Autor: DeRose YS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE

Publikováno v: Current protocols in pharmacology [Curr Protoc Pharmacol] 2013 Mar; Vol. Chapter 14, pp. Unit14.23.

Short-Form Ron Promotes Spontaneous Breast Cancer Metastasis through Interaction with Phosphoinositide 3-Kinase.

Autor: Liu X; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Zhao L, Derose YS, Lin YC, Bieniasz M, Eyob H, Buys SS, Neumayer L, Welm AL

Publikováno v: Genes & cancer [Genes Cancer] 2011 Jul; Vol. 2 (7), pp. 753-62.