Uncovering patterns of inhaler technique and reliever use: the value of objective, personalized data from a digital inhaler

Autor: Mark L. Levy, Janwillem W. H. Kocks, Sinthia Bosnic-Anticevich, Guilherme Safioti, Michael Reich, Michael Depietro, Mario Castro, Nabeel Farooqui, Njira L. Lugogo, Randall Brown, Tanisha Hill, Thomas Li, Henry Chrystyn

Publikováno v: npj Primary Care Respiratory Medicine, Vol 34, Iss 1, Pp 1-11 (2024)

Abstract Electronic inhalers provide information about patterns of routine inhaler use. During a 12-week study, 360 asthma patients using albuterol Digihaler generated 53,083 inhaler events that were retrospectively analyzed. A total of 41,528 (78%)

Externí odkaz: https://doaj.org/article/3bf71b9b84cc4be7864107459e0965b2

Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer

Autor: R. J. Seager, Maria-Fernanda Senosain, Erik Van Roey, Shuang Gao, Paul DePietro, Mary K. Nesline, Durga Prasad Dash, Shengle Zhang, Heidi Ko, Stephanie B. Hastings, Kyle C. Strickland, Rebecca A. Previs, Taylor J. Jensen, Marcia Eisenberg, Brian J. Caveney, Eric A. Severson, Shakti Ramkissoon, Jeffrey M. Conroy, Sarabjot Pabla

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Background Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression drives the metastasis and progression of lung cancer, and is associated

Externí odkaz: https://doaj.org/article/c349be77b0f14a3eaaf56d8588b10579

Measurement of the Masses and Widths of the $\Sigma_c(2455)^+$ and $\Sigma_c(2520)^+$ Baryons

Autor: Belle Collaboration, Yelton, J., Adachi, I., Ahn, J. K., Aihara, H., AlSaid, S., Asner, D. M., Atmacan, H., Aulchenko, V., Aushev, T., Ayad, R., Babu, V., Bahinipati, S., Behera, P., Belous, K., Bennett, J., Bessner, M., Bhardwaj, V., Bhuyan, B., Bilka, T., Biswal, J., Bozek, A., Bracko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Cervenkov, D., Chang, M. -C., Chang, P., Chekelian, V., Chen, A., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Cho, S. -J., Choi, S. -K., Choi, Y., Choudhury, S., Cinabro, D., Cunliffe, S., Das, S., Dash, N., DeNardo, G., DePietro, G., Dhamija, R., DiCapua, F., Dingfelder, J., Dolezal, Z., Dong, T. V., Epifanov, D., Ferber, T., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Gabyshev, N., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Gudkova, K., Hadjivasiliou, C., Hara, T., Hartbrich, O., Hayasaka, K., Hayashii, H., Hou, W. -S., Hsu, C. -L., Inami, K., Ishikawa, A., Itoh, R., Iwasaki, M., Iwasaki, Y., Jacobs, W. W., Jia, S., Jin, Y., Joo, K. K., Kaliyar, A. B., Kang, K. H., Kato, Y., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, S. H., Kim, Y. -K., Kinoshita, K., Kodys, P., Konno, T., Korobov, A., Korpar, S., Kovalenko, E., Krizan, P., Kroeger, R., Krokovny, P., Kuhr, T., Kulasiri, R., Kumara, K., Kwon, Y. -J., Lange, J. S., Laurenza, M., Lee, S. C., Li, J., Li, L. K., Li, Y. B., LiGioi, L., Libby, J., Lieret, K., Liventsev, D., MacQueen, C., Masuda, M., Matsuda, T., Matvienko, D., McNeil, J. T., Merola, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Moon, T. J., Mussa, R., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Niiyama, M., Nisar, N. K., Nishida, S., Ogawa, S., Ono, H., Onuki, Y., Oskin, P., Pakhlov, P., Pakhlova, G., Pardi, S., Park, H., Park, S. -H., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Rostomyan, A., Rout, N., Russo, G., Sahoo, D., Sakai, Y., Sandilya, S., Sangal, A., Santelj, L., Sanuki, T., Savinov, V., Schnell, G., Schueler, J., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shapkin, M., Sharma, C., Shen, C. P., Shiu, J. -G., Sokolov, A., Solovieva, E., Staric, M., Stottler, Z. S., Sumihama, M., Sumisawa, K., Sumiyoshi, T., Takizawa, M., Tamponi, U., Tanida, K., Tao, Y., Tenchini, F., Trabelsi, K., Uchida, M., Uglov, T., Unno, Y., Uno, S., Urquijo, P., Usov, Y., Vahsen, S. E., VanTonder, R., Varner, G., Vinokurova, A., Waheed, E., Wang, C. H., Wang, D., Wang, E., Wang, M. -Z., Wang, P., Watanabe, M., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Ye, H., Yin, J. H., Yuan, C. Z., Zhang, Z. P., Zhilich, V., Zhukova, V.

Publikováno v: Phys. Rev. D 104, 052003 (2021)

Using 980 ${\rm fb}^{-1}$ of data {collected} with the Belle detector operating at the KEKB asymmetric-energy $e^+e^-$ collider, we report the measurements of the masses, and the first measurements of the instrinsic widths, of the $\Sigma_c(2455)^+$

Externí odkaz: http://arxiv.org/abs/2107.05615

T-cell priming transcriptomic markers: implications of immunome heterogeneity for precision immunotherapy

Autor: Hirotaka Miyashita, Razelle Kurzrock, Nicholas J. Bevins, Kartheeswaran Thangathurai, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Sean T. Glenn, Jeffrey M. Conroy, Paul DePietro, Eitan Rubin, Jason K. Sicklick, Shumei Kato

Publikováno v: npj Genomic Medicine, Vol 8, Iss 1, Pp 1-10 (2023)

Abstract Immune checkpoint blockade is effective for only a subset of cancers. Targeting T-cell priming markers (TPMs) may enhance activity, but proper application of these agents in the clinic is challenging due to immune complexity and heterogeneit

Externí odkaz: https://doaj.org/article/9b9d07a8e8b84b69aa3ad5d3d41c13e8

High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome

Autor: Nithya Krishnamurthy, Daisuke Nishizaki, Scott M. Lippman, Hirotaka Miyashita, Mary K. Nesline, Sarabjot Pabla, Jeffrey M. Conroy, Paul DePietro, Shumei Kato, Razelle Kurzrock

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 16 (2024)

Background: CTLA-4 impedes the immune system’s antitumor response. There are two Food and Drug Administration-approved anti-CTLA-4 agents – ipilimumab and tremelimumab – both used together with anti-PD-1/PD-L1 agents. Objective: To assess the p

Externí odkaz: https://doaj.org/article/302a5bad7fa94428a127ac93ea60fd33