Zobrazeno 1 - 10 of 179 pro vyhledávání: '"DeMent, K."'
1
Akademický článek
Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.
Autor: Sabat M; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Carney DW; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Hernandez-Torres G; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Gibson TS; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Balakrishna D; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Zou H; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Xu R; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Chen CH; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., de Jong R; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Dougan DR; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Qin L; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Bigi-Botterill SV; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Chambers A; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Miura J; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Johnson LK; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Ermolieff J; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Johns D; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Selimkhanov J; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Kwok L; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., DeMent K; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Proffitt C; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Vu P; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Lindsey EA; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Ivetac T; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Jennings A; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Wang H; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Manam P; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Santos C; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Fullenwider C; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Manohar R; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States., Flick AC; Gastroenterology Drug Discovery Unit, Takeda Development Center Americas, Inc., 9625 Towne Centre Dr., San Diego, California 92121 United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10306-10320. Date of Electronic Publication: 2024 Jun 13.
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2
Akademický článek
GTP1 metabolic stability assessment: A study of the tau PET tracer [ 18 F]GTP1.
Autor: Marik J; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA. Electronic address: marik.jan@gene.com., Rich S; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Deshmukh G; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Zhang D; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Tinianow J; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Cai J; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Wong S; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Bobba S; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., DeMent K; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Liu N; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Halladay J; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Sanabria-Bohórquez S; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Cheruzel L; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA., Khojasteh C; Genentech Research and Early Development (gRED), Genentech Inc., 1 DNA way, South San Francisco, CA 94080, USA.
Publikováno v: Nuclear medicine and biology [Nucl Med Biol] 2023 Sep-Oct; Vol. 124-125, pp. 108386. Date of Electronic Publication: 2023 Sep 04.
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3
Akademický článek
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
Autor: Taylor AM; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Bailey C; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Belmont LD; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Campbell R; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Cantone N; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Côté A; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Crawford TD; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Cummings R; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., DeMent K; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Duplessis M; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Flynn M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Good AC; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Huang HR; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Joshi S; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Leblanc Y; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Murray J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Nasveschuk CG; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Neiss A; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Poy F; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Romero FA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sandy P; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Tang Y; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Tsui V; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Zawadzke L; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Sims RJ 3rd; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Audia JE; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Bellon SF; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Magnuson SR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Albrecht BK; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Cochran AG; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11177-11186. Date of Electronic Publication: 2022 Aug 05.
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4
Akademický článek
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
Autor: Petersson C; The Healthcare Business of Merck KGaA, Frankfurter Str. 250, Postcode D50/902, 64293, Darmstadt, Germany. carl.petersson@merckgroup.com., Zhou X; Eli Lilly and Company, Indianapolis, IN, USA., Berghausen J; Novartis, Basel, Switzerland., Cebrian D; GSK, Brentford, UK., Davies M; AstraZeneca, Cambridge, UK., DeMent K; Takeda Pharmaceuticals International, Inc., Deerfield, IL, USA.; XinThera, Inc., San Diego, CA, USA., Eddershaw P; Vertex Pharmaceuticals Incorporated, Boston, MA, USA., Riedmaier AE; Bristol-Myers Squibb, New York, NY, USA., Leblanc AF; AbbVie Inc., North Chicago, IL, USA., Manveski N; F. Hoffman-La Roche Ltd., Basel, Switzerland., Marathe P; Agios Pharmaceuticals, Cambridge, MA, USA., Mavroudis PD; Sanofi, Paris, France., McDougall R; Alnylam Pharmaceuticals, Inc., Cambridge, MA, USA.; Repare Therapeutics, Quebec City, Canada., Parrott N; F. Hoffman-La Roche Ltd., Basel, Switzerland., Reichel A; Bayer AG, Leverkusen, Germany., Rotter C; Takeda Pharmaceuticals International, Inc., Deerfield, IL, USA., Tess D; Pfizer, Inc., New York, NY, USA., Volak LP; Janssen Research and Development, LLC, Raritan, NJ, USA., Xiao G; Sunovion Pharmaceuticals, Inc., Marlborough, MA, USA., Yang Z; Bristol-Myers Squibb, New York, NY, USA., Baker J; Merck and Co., Inc, Kenilworth, NJ, USA.; Blueprint Medicines, Cambridge, MA, USA.
Publikováno v: The AAPS journal [AAPS J] 2022 Jul 19; Vol. 24 (5), pp. 85. Date of Electronic Publication: 2022 Jul 19.
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5
Akademický článek
Key Factors for Improving Predictive Accuracy and Avoiding Overparameterization of the PBPK Absorption Model in Food Effect Studies of Weakly Basic Water-Insoluble Compounds in Immediate Release Formulations.
Autor: Zhang, Miao1,2 (AUTHOR) mia.zhang@northeastern.edu, Zhang, Shudong3 (AUTHOR), Wang, Lin3 (AUTHOR), Zhang, Zhe3 (AUTHOR), Hu, Qin3 (AUTHOR) huqin@bidc.org.cn, Liu, Dongyang1 (AUTHOR) huqin@bidc.org.cn
Publikováno v: Pharmaceutics. Oct2024, Vol. 16 Issue 10, p1324. 20p.
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6
Akademický článek
Understanding the mechanisms of food effect on omaveloxolone pharmacokinetics through physiologically based biopharmaceutics modeling.
Autor: Pepin, Xavier J. H.1 (AUTHOR) xavier.pepin@simulations‐plus.com, Hynes, Scott M.2 (AUTHOR), Zahir, Hamim2 (AUTHOR), Walker, Deborah3 (AUTHOR), Semmens, Lois Q.2 (AUTHOR), Suarez‐Sharp, Sandra1 (AUTHOR)
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Oct2024, Vol. 13 Issue 10, p1771-1783. 13p.
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7
Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.
Autor: Riedmaier AE; DMPK and Translational Modeling, AbbVie Inc., North Chicago, Illinois, USA. arian.emamiriedmaier@abbvie.com., DeMent K; Global DMPK, Takeda Pharmaceutical Co., Ltd., San Diego, California, USA., Huckle J; Drug Product Technology, Amgen, Thousand Oaks, California, USA., Bransford P; Modeling & Informatics, Vertex Pharmaceuticals, Boston, Massachusetts, USA., Stillhart C; Pharmaceutical R&D, Formulation & Process Sciences, F.Hoffmann-La Roche Ltd., Basel, Switzerland., Lloyd R; Computational & Modelling Sciences, Platform Technology Sci-ences, GlaxoSmithKline R&D, Ware, Hertfordshire, UK., Alluri R; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Basu S; Pharmacokinetic, Pharmacodynamic and Drug Metabolism-Quantitative Pharmacology and Pharmacometrics (PPDM-QP2),Merck & Co, Inc., West Point, Pennsylvania, USA., Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California, USA., Dhamankar V; Formulation Development, Vertex Pharmaceuticals, Boston, Massachusetts, USA.; Formulation Development, Cyclerion Therapeu-tics Inc., Cambridge, Massachusetts, USA., Dodd S; Chemical & Pharmaceutical Profiling, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Kulkarni P; Department of Pharmacokinetics and Drug Metabolism, AmgenInc, Cambridge, Massachusetts, USA., Olivares-Morales A; Pharmaceutical Sciences, Roche Pharmaceutical Research andEarly Development, Roche Innovation Center, Basel, Switzerland., Peng CC; Department of Pharmacokinetics and Drug Metabolism, AmgenInc, Cambridge, Massachusetts, USA.; Drug Metabolism and Pharmacokinetics, Theravance Biopharma, South San Francisco, California, USA., Pepin X; New Modalities and Parenteral Development, PharmaceuticalTechnology & Development, Operations, AstraZeneca, Maccles-field, UK., Ren X; Modeling & Simulation, PK Sciences, Novartis Institutes of Biomedical Research, East Hanover, New Jersey, USA., Tran T; Computational & Modelling Sciences, Platform Technology Sci-ences, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA., Tistaert C; Pharmaceutical Sciences, Janssen Research & Development, Beerse, Belgium., Heimbach T; PBPK & Biopharmaceutics, Novartis Institutes of Biomedical Research, Wayne, New Jersey, USA., Kesisoglou F; Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, New Jersey, USA., Wagner C; Pharmaceutical Technologies, Chemical and Pharmaceutical De-velopment, Merck Healthcare KGaA, Darmstadt, Germany., Parrott N; Pharmaceutical Sciences, Roche Pharmaceutical Research andEarly Development, Roche Innovation Center, Basel, Switzerland.
Publikováno v: The AAPS journal [AAPS J] 2020 Nov 26; Vol. 23 (1), pp. 6. Date of Electronic Publication: 2020 Nov 26.
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8
Akademický článek
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.
Autor: Riedmaier AE; DMPK and Translational Modeling, AbbVie Inc., North Chicago, Illinois, USA. arian.emamiriedmaier@abbvie.com., DeMent K; Global DMPK, Takeda Pharmaceutical Co., Ltd., San Diego, California, USA., Huckle J; Drug Product Technology, Amgen, Thousand Oaks, California, USA., Bransford P; Modeling & Informatics, Vertex Pharmaceuticals, Boston, Massachusetts, USA., Stillhart C; Pharmaceutical R&D, Formulation & Process Sciences, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Lloyd R; Computational & Modelling Sciences, Platform Technology Sciences, GlaxoSmithKline R&D, Ware, Hertfordshire, UK., Alluri R; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Basu S; Pharmacokinetic, Pharmacodynamic and Drug Metabolism-Quantitative Pharmacology and Pharmacometrics (PPDM-QP2), Merck & Co, Inc., West Point, Pennsylvania, USA., Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California, USA., Dhamankar V; Formulation Development, Vertex Pharmaceuticals, Boston, Massachusetts, USA.; Formulation Development, Cyclerion Therapeutics Inc., Cambridge, Massachusetts, USA., Dodd S; Chemical & Pharmaceutical Profiling, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Kulkarni P; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts, USA., Olivares-Morales A; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland., Peng CC; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts, USA.; Drug Metabolism and Pharmacokinetics, Theravance Biopharma, South San Francisco, California, USA., Pepin X; New Modalities and Parenteral Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK., Ren X; Modeling & Simulation, PK Sciences, Novartis Institutes of Biomedical Research, East Hanover, New Jersey, USA., Tran T; Computational & Modelling Sciences, Platform Technology Sciences, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA., Tistaert C; Pharmaceutical Sciences, Janssen Research & Development, Beerse, Belgium., Heimbach T; PBPK & Biopharmaceutics, Novartis Institutes of Biomedical Research, Wayne, New Jersey, USA., Kesisoglou F; Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, New Jersey, USA., Wagner C; Pharmaceutical Technologies, Chemical and Pharmaceutical Development, Merck Healthcare KGaA, Darmstadt, Germany., Parrott N; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Publikováno v: The AAPS journal [AAPS J] 2020 Sep 27; Vol. 22 (6), pp. 123. Date of Electronic Publication: 2020 Sep 27.
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9
Akademický článek
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Autor: Parr BT; Genentech, South San Francisco, California 94080, United States., Pastor R; Genentech, South San Francisco, California 94080, United States., Sellers BD; Genentech, South San Francisco, California 94080, United States., Pei Z; Genentech, South San Francisco, California 94080, United States., Jaipuri FA; NewLink Genetics, Ames, Iowa 50010, United States., Castanedo GM; Genentech, South San Francisco, California 94080, United States., Gazzard L; Genentech, South San Francisco, California 94080, United States., Kumar S; NewLink Genetics, Ames, Iowa 50010, United States., Li X; NewLink Genetics, Ames, Iowa 50010, United States., Liu W; Genentech, South San Francisco, California 94080, United States., Mendonca R; Genentech, South San Francisco, California 94080, United States., Pavana RK; NewLink Genetics, Ames, Iowa 50010, United States., Potturi H; NewLink Genetics, Ames, Iowa 50010, United States., Shao C; Pharmaron, Beijing 100176, People's Republic of China., Velvadapu V; NewLink Genetics, Ames, Iowa 50010, United States., Waldo JP; NewLink Genetics, Ames, Iowa 50010, United States., Wu G; Pharmaron, Beijing 100176, People's Republic of China., Yuen PW; Pharmaron, Beijing 100176, People's Republic of China., Zhang Z; NewLink Genetics, Ames, Iowa 50010, United States., Zhang Y; Pharmaron, Beijing 100176, People's Republic of China., Harris SF; Genentech, South San Francisco, California 94080, United States., Oh AJ; Genentech, South San Francisco, California 94080, United States., DiPasquale A; Genentech, South San Francisco, California 94080, United States., Dement K; Genentech, South San Francisco, California 94080, United States., La H; Genentech, South San Francisco, California 94080, United States., Goon L; Genentech, South San Francisco, California 94080, United States., Gustafson A; Genentech, South San Francisco, California 94080, United States., VanderPorten EC; Genentech, South San Francisco, California 94080, United States., Mautino MR; NewLink Genetics, Ames, Iowa 50010, United States., Liu Y; Genentech, South San Francisco, California 94080, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Mar 04; Vol. 11 (4), pp. 541-549. Date of Electronic Publication: 2020 Mar 04 (Print Publication: 2020).
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10
Akademický článek
Tipifarnib physiologically‐based pharmacokinetic modeling to assess drug–drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients.
Autor: Okudaira, Noriko1 (AUTHOR), Burt, Howard1 (AUTHOR), Mitra, Amitava2 (AUTHOR) amitra@kuraoncology.com
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Aug2024, Vol. 13 Issue 8, p1366-1379. 14p.
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