Zobrazeno 1 - 10
of 17
pro vyhledávání: '"DeMarco V. Camper"'
Autor:
Edward T. Olejniczak, Melissa A. Fischer, DeMarco V. Camper, Taekyu Lee, Lawrence H. Boise, Michael R. Savona, Leah Hogdal, Carrie F. Browning, Brian Koss, Bin Zhao, Anthony Letai, Johannes Belmar, James C. Tarr, Olivia W. Rossanese, Nagarathanam Veerasamy, Zhiguo Bian, Amit Budhraja, Shannon M. Matulis, Stephen W. Fesik, Subrata Shaw, John Sensintaffar, Joseph T. Opferman, Craig M. Goodwin, Allison L. Arnold
Publikováno v:
FEBS Letters. 591:240-251
Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins that when overexpressed is associated with high tumor grade, poor survival, and resistance to chemotherapy. Mcl-1 is amplified in many human cancers, and knockdown of Mcl-1 using RNAi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7b42e25c5eb5c232c4857969b56b317
https://doi.org/10.1002/1873-3468.12497
https://doi.org/10.1002/1873-3468.12497
Autor:
Jason Phan, Olivia W. Rossanese, J.G. Shaw, Chao Han, Leiber Thomas, DeMarco V. Camper, Bin Zhao, Erin R. Aho, S.W. Fesik, Joseph Alvarado, J.A. Bauer, Feng Wang, Bethany M. Alicie, Joannes P. Yuh, Jennifer E. Howes, Jonathan David Macdonald, Sameer Nikhar, Jiqing Sai, William G. Payne, S. Chacon Simon, Alex G. Waterson, Shaun R. Stauffer, William P. Tansey
Publikováno v:
Journal of medicinal chemistry. 62(24)
The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3674d0595ce1b6e8dc02b864870b3195
https://pubmed.ncbi.nlm.nih.gov/31724864
https://pubmed.ncbi.nlm.nih.gov/31724864
Autor:
Craig M. Goodwin, Claire Gregg, N.F. Pelz, Edward T. Olejniczak, Allison L. Arnold, James C. Tarr, Zhiguo Bian, Stephen W. Fesik, DeMarco V. Camper, Olivia W. Rossanese, Anders Friberg, Taekyu Lee, Johannes Belmar, Bin Zhao, Subrata Shaw, John Sensintaffar
Publikováno v:
Journal of Medicinal Chemistry. 59:2054-2066
Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death (PCD). Amplification of Mcl-1 is a common genetic aberration in human cancer whose overexpression contributes to the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6586689f68249d97a21cc8e455b9dc6
https://doi.org/10.1021/acs.jmedchem.5b01660
https://doi.org/10.1021/acs.jmedchem.5b01660
Autor:
Walter J. Chazin, Carrie F. Browning, Edward T. Olejniczak, J.D. Patrone, Bhavatarini Vangamudi, Alex G. Waterson, Stephen W. Fesik, Benjamin A. Gilston, Elaine M. Souza-Fagundes, DeMarco V. Camper, Michael D. Feldkamp, Olivia W. Rossanese, Andreas O. Frank, N.F. Pelz, Brittney S. Bates, Alexey G. Kuznetsov
Publikováno v:
ChemMedChem. 11:893-899
Replication protein A (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein interactions (PPIs) mediated by its 70N domain. The identification and use of chemical prob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b943ba901b0b67263224cce5f311d58
https://doi.org/10.1002/cmdc.201500479
https://doi.org/10.1002/cmdc.201500479
Autor:
Kyu Ok Jeon, Edward T. Olejniczak, Jason Phan, Rocco D. Gogliotti, Shaun R. Stauffer, J. Grace Shaw, Joannes P. Yuh, Joseph Alvarado, Olivia W. Rossanese, Stephen W. Fesik, William P. Tansey, Jiqing Sai, Jonathan David Macdonald, Shi-Dong Wang, Qi Sun, Feng Wang, James M. Salovich, DeMarco V. Camper
Publikováno v:
Journal of medicinal chemistry. 61(13)
WDR5 is a chromatin-regulatory scaffold protein overexpressed in various cancers and a potential epigenetic drug target for the treatment of mixed-lineage leukemia. Here, we describe the discovery of potent and selective WDR5-WIN-site inhibitors usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451315dd292e4c2214fea8519ca5ff8f
https://pubmed.ncbi.nlm.nih.gov/29889518
https://pubmed.ncbi.nlm.nih.gov/29889518
Autor:
Taekyu Lee, Stephen W. Fesik, Jason R. Abbott, Michael C. Burns, Alex G. Waterson, Jason Phan, Andrew J. Little, Jennifer E. Howes, DeMarco V. Camper, Qi Sun, Olivia W. Rossanese
K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although directly targeting RAS h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ffba8a7655eb51cb6092a54f8e2a7d
https://europepmc.org/articles/PMC5935105/
https://europepmc.org/articles/PMC5935105/
Autor:
Stephen W. Fesik, Edward T. Olejniczak, DeMarco V. Camper, Subrata Shaw, Zhiguo Bian, John Sensintaffar, Nagarathanam Veerasamy, Allison L. Arnold, Olivia W. Rossanese, Bin Zhao, Evan Perry, Stuart A. Fogarty, Kyu Ok Jeon, James C. Tarr, Taekyu Lee, Johannes Belmar
Publikováno v:
Journal of medicinal chemistry. 61(6)
Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, has emerged as an attractive target for cancer therapy. Mcl-1 upregulation is often found in many human cancers and is associated with high tumor grade, poor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a136bc4d9ab1f798479952b5cd38bcd
https://pubmed.ncbi.nlm.nih.gov/29323899
https://pubmed.ncbi.nlm.nih.gov/29323899
Autor:
Taekyu Lee, Stephen W. Fesik, Pedro M. Garcia-Barrantes, Edward T. Olejniczak, Jason P. Burke, Bin Zhao, Brian A. Chauder, Anders Friberg, R. Nathan Daniels, Dominico Vigil, DeMarco V. Camper
Publikováno v:
Journal of Medicinal Chemistry. 56:15-30
Myeloid cell leukemia 1 (Mcl-1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and promotes the aberrant survival of tumor cells that otherwise would undergo apoptosis. Here we describe the discovery of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a5af2f525a4290db68505dbbfe89f6
https://doi.org/10.1021/jm301448p
https://doi.org/10.1021/jm301448p
Autor:
Qi Sun, Taekyu Lee, Jason Phan, Stephen W. Fesik, Jason R. Abbott, Michael C. Burns, Jennifer E. Howes, Andrew J. Little, Olivia W. Rossanese, DeMarco V. Camper, Denis T. Akan, Alex G. Waterson
Publikováno v:
Cancer Research. 78:865-865
Oncogenic mutation of Ras is responsible for more than 30% of all human tumors. Therefore, pharmacological modulation of Ras has attracted great interest as a therapeutic strategy. Our laboratory has recently discovered small molecules that activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85fb1c88eddf5b73f26b0d8cb36be958
https://doi.org/10.1158/1538-7445.am2018-865
https://doi.org/10.1158/1538-7445.am2018-865
Autor:
Ronald E. Viola, DeMarco V. Camper
Publikováno v:
Analytical Biochemistry. 393:176-181
Obtaining highly purified proteins is essential to begin investigating their functional and structural properties. The steps that are typically involved in purifying proteins can include an initial capture, intermediate purification, and a final poli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bea426888d0dffeb7630f822331c70
https://doi.org/10.1016/j.ab.2009.07.009
https://doi.org/10.1016/j.ab.2009.07.009