Zobrazeno 1 - 10
of 87
pro vyhledávání: '"DeManno, A."'
Autor:
Neff, G.W. *, O'Brien, C.B., Shire, N.J., DeManno, A., Kahn, S., Rideman, E., Safdar, K., Madariaga, J., Rudich, S.R.
Publikováno v:
In Transplantation Proceedings 2004 36(10):3071-3074
Publikováno v:
The Journal of Clinical Pharmacology. 57:52-63
The presented analysis was performed to characterize the relationship between treatment-related early (week 4) and longer term (3-6 months) weight loss to understand the potential utility of 4-week proof-of-mechanism studies in the early decision-mak
Autor:
Kristof Chwalisz, Jiayin Wang, Akira Morikawa, Deborah A. DeManno, Takeshi Maruo, Wei Chen, Noriyuki Ohara
Publikováno v:
Reproductive Sciences. 14:20-27
Progesterone plays a pivotal role in controlling uterine leiomyoma growth. The authors review studies they conducted to evaluate the comparative effects of asoprisnil on proliferation, apoptosis, and growth factor expression in cultured leiomyoma and
Autor:
Takeshi Maruo, Deborah A. DeManno, Jin Liu, Kristof Chwalisz, Noriyuki Ohara, Koji Nakabayashi, Qin Xu, Shigeki Yoshida
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 293:E1002-E1011
A recent clinical trial (Chwalisz K, Larsen L, Mattia-Goldberg C, Edmonds A, Elger W, Winkel CA. Fertil Steril 87: 1399–1412, 2007) has demonstrated that the selective progesterone receptor modulator asoprisnil efficiently causes the shrinkage of u
Autor:
Wei Chen, Akira Morikawa, Kristof Chwalisz, Deborah A. DeManno, Jiayin Wang, Hiroko Sasaki, Noriyuki Ohara, Zhuo Wang, Takeshi Maruo
Publikováno v:
Human Reproduction. 21:1869-1877
Background This study was conducted to evaluate the effects of a novel selective progesterone receptor modulator (SPRM) asoprisnil on the expression of growth factors and their receptors and on growth factor-induced proliferation of cultured uterine
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Autor:
Deborah A. DeManno, Gerd Schubert, Maria Claudia Perez, Kristof Chwalisz, Walter Elger, Craig Winkel
Publikováno v:
Endocrine Reviews. 26:423-438
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective progesterone agonist, antagonist, or mixed agonist/antagonist effects on various progesterone
Autor:
Antoinette DeManno, Guy W. Neff, Douglas Meyer, Eugene R. Schiff, Marzia Montalbano, Halim Muslu, Christopher B. O'Brien, Stephanie Kahn, Kamran Safdar, Seigo Nishida
Publikováno v:
Digestive Diseases and Sciences. 49:1186-1189
Autor:
Guy W. Neff, Andreas G. Tzakis, Kamran Safdar, Antoinette DeManno, Seigo Nishida, Stephanie Kahn, Marzia Montalbano, Christopher B. O'Brien
Publikováno v:
Liver Transplantation. 10:881-885
The extensive use of alternative medicine products, herbal remedies, and vitamins in large doses has reached an all time high in the general public. Some agents are reported and advertised as immune stimulants and may interfere with patients sufferin
Autor:
Deborah A. DeManno, Gerd Schubert, Ramesh Garg, Holger Hess-Stumpp, Ronald Lee, Kristof Chwalisz, Birgitt Schneider, Walter Elger
Publikováno v:
Steroids. 68:1019-1032
Asoprisnil is a novel selective steroid receptor modulator that shows unique pharmacodynamic effects in animal models and humans. Asoprisnil, its major metabolite J912, and structurally related compounds represent a new class of progesterone receptor