Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer.

Autor: Labrecque MP; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA., Brown LG; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA., Coleman IM; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Nguyen HM; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA., Dalrymple S; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Brennen WN; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Isaacs JT; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Li D; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA., Lakely B; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA., DeLucia DC; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Lee JK; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA., Schweizer MT; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Lin DW; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA.; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Corey E; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA., Nelson PS; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Morrissey C; Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA.

Publikováno v: The Prostate [Prostate] 2024 Jan; Vol. 84 (1), pp. 100-110. Date of Electronic Publication: 2023 Oct 05.

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.

Autor: Chour W; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Choi J; Institute for Systems Biology, Seattle, WA, 98109, USA., Xie J; Institute for Systems Biology, Seattle, WA, 98109, USA.; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA, 98195, USA., Chaffee ME; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Schmitt TM; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Finton K; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., DeLucia DC; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Xu AM; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Su Y; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Chen DG; Institute for Systems Biology, Seattle, WA, 98109, USA.; Department of Microbiology and Department of Informatics, University of Washington, Seattle, WA, 98195, USA., Zhang R; Institute for Systems Biology, Seattle, WA, 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA., Yuan D; Institute for Systems Biology, Seattle, WA, 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA., Hong S; Institute for Systems Biology, Seattle, WA, 98109, USA., Ng AHC; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Butler JZ; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Edmark RA; Institute for Systems Biology, Seattle, WA, 98109, USA., Jones LC; Institute for Systems Biology, Seattle, WA, 98109, USA., Murray KM; Institute for Systems Biology, Seattle, WA, 98109, USA., Peng S; PACT Pharma, South San Francisco, CA, 94080, USA., Li G; Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.; Suzhou Institute of Systems Medicine, Suzhou, 215123, China.; Key Laboratory of Synthetic Biology Regulatory Element, Chinese Academy of Medical Sciences, Beijing, China., Strong RK; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Lee JK; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Goldman JD; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, 98104, USA.; Division of Infectious Disease, Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Greenberg PD; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, 98195, USA.; Department of Immunology, University of Washington, Seattle, WA, 98195, USA., Heath JR; Institute for Systems Biology, Seattle, WA, 98109, USA. Jheath@isbscience.org.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. Jheath@isbscience.org.

Publikováno v: Communications biology [Commun Biol] 2023 May 16; Vol. 6 (1), pp. 528. Date of Electronic Publication: 2023 May 16.

Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.

Autor: Mao Z; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095., Nesterenko PA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.; Molecular Biology Institute, University of California, Los Angeles, CA 90095., McLaughlin J; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Deng W; Molecular Biology Institute, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Burton Sojo G; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Cheng D; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095., Noguchi M; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Chour W; Institute for Systems Biology, Seattle, WA 98109., DeLucia DC; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Finton KA; Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Qin Y; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Obusan MB; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Tran W; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Wang L; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Bangayan NJ; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095., Ta L; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095., Chen CC; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095., Seet CS; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095., Crooks GM; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Division of Pediatric Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Phillips JW; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095., Heath JR; Institute for Systems Biology, Seattle, WA 98109., Strong RK; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Lee JK; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98109.; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195., Wohlschlegel JA; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Witte ON; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095.; Molecular Biology Institute, University of California, Los Angeles, CA 90095.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, CA 90095.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 02; Vol. 119 (31), pp. e2203410119. Date of Electronic Publication: 2022 Jul 25.

B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 ⁺ T Cells: Implications for the Viral Reservoir.

Autor: Gerberick A; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., DeLucia DC; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Piazza P; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Alaoui-El-Azher M; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Rinaldo CR; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sluis-Cremer N; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA nps2@pitt.edu giovanna@pitt.edu., Rappocciolo G; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA nps2@pitt.edu giovanna@pitt.edu.

Publikováno v: MBio [mBio] 2021 Mar 09; Vol. 12 (2). Date of Electronic Publication: 2021 Mar 09.

Identification of Cell Surface Targets for CAR T Cell Immunotherapy.

Autor: DeLucia DC; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA., Lee JK; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. jklee5@fredhutch.org.; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. jklee5@fredhutch.org.; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. jklee5@fredhutch.org.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2097, pp. 45-54.