Effect of age, ethnicity, sex, cognitive status and APOE genotype on amyloid load and the threshold for amyloid positivity

Autor: R. Duara, D.A. Loewenstein, G. Lizarraga, M. Adjouadi, W.W. Barker, M.T. Greig-Custo, M. Rosselli, A. Penate, Y.F. Shea, R. Behar, A. Ollarves, C. Robayo, K. Hanson, M. Marsiske, S. Burke, N. Ertekin-Taner, D. Vaillancourt, S. De Santi, T. Golde, DeKosky ST

Publikováno v: NeuroImage: Clinical, Vol 22, Iss , Pp - (2019)

The threshold for amyloid positivity by visual assessment on PET has been validated by comparison to amyloid load measured histopathologically and biochemically at post mortem. As such, it is now feasible to use qualitative visual assessment of amylo

Externí odkaz: https://doaj.org/article/7e564226094b45259cc3d0dd26ffd645

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Autor: Naj, AC, Jun, G, Beecham, GW, Wang, LS, Vardarajan, BN, Buros, J, Gallins, PJ, Buxbaum, JD, Jarvik, GP, Crane, PK, Larson, EB, Bird, TD, Boeve, BF, Graff-Radford, NR, De Jager, PL, Evans, D, Schneider, JA, Carrasquillo, MM, Ertekin-Taner, N, Younkin, SG, Cruchaga, C, Kauwe, JSK, Nowotny, P, Kramer, P, Hardy, J, Huentelman, MJ, Myers, AJ, Barmada, MM, Demirci, FY, Baldwin, CT, Green, RC, Rogaeva, E, George-Hyslop, PS, Arnold, SE, Barber, R, Beach, T, Bigio, EH, Bowen, JD, Boxer, A, Burke, JR, Cairns, NJ, Carlson, CS, Carney, RM, Carroll, SL, Chui, HC, Clark, DG, Corneveaux, J, Cotman, CW, Cummings, JL, Decarli, C, Dekosky, ST, Diaz-Arrastia, R, Dick, M, Dickson, DW, Ellis, WG, Faber, KM, Fallon, KB, Farlow, MR, Ferris, S, Frosch, MP, Galasko, DR, Ganguli, M, Gearing, M, Geschwind, DH, Ghetti, B, Gilbert, JR, Gilman, S, Giordani, B, Glass, JD, Growdon, JH, Hamilton, RL, Harrell, LE, Head, E, Honig, LS, Hulette, CM, Hyman, BT, Jicha, GA, Jin, LW, Johnson, N, Karlawish, J, Karydas, A, Kaye, JA, Kim, R

Publikováno v: Naj, AC; Jun, G; Beecham, GW; Wang, LS; Vardarajan, BN; Buros, J; et al.(2011). Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics, 43(5), 436-443. doi: 10.1038/ng.801. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6xc596k3

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9f53ff000ffc5d3502416acdaff6517b
http://www.escholarship.org/uc/item/6xc596k3

The World of Dementia Beyond 2020

Autor: Brodaty, H, Breteler, Monique, DeKosky, ST, Dorenlot, P, Fratiglioni, L, Hock, C, Kenigsberg, PA, Scheltens, P, De Strooper, B

Publikováno v: Brodaty, H, Breteler, M M B, Dekosky, S T, Dorenlot, P, Fratiglioni, L, Hock, C, Kenigsberg, P A, Scheltens, P & De Strooper, B 2011, ' The World of Dementia Beyond 2020 ', Journal of the American Geriatrics Society, vol. 59, no. 5, pp. 923-927 . https://doi.org/10.1111/j.1532-5415.2011.03365.x
Journal of the American Geriatrics Society, 59(5), 923-927. Wiley-Blackwell
Journal of American Geriatrics Society, 59(5), 923-927. Wiley-Blackwell Publishing Ltd

Counterpoised against dire projections of the tripling of the prevalence of dementia over the next 40 years are major developments in diagnostic biomarkers, neuroimaging, the molecular biology of Alzheimer's disease (AD), epidemiology of risk and pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6474e5febae6380c95cfa6d7edb449a2
https://research.vumc.nl/en/publications/a324bdd9-71ae-4634-956b-2fa1c6780528

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