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Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice.

Autor: Wolf MA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., O'Hara JM; Moderna Inc., Cambridge, MA, 02139, USA., Bitzer GJ; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Narayanan E; Moderna Inc., Cambridge, MA, 02139, USA., Boehm DT; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Bevere JR; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., DeJong MA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Hall JM; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Wong TY; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Falcone S; Moderna Inc., Cambridge, MA, 02139, USA., Deal CE; Moderna Inc., Cambridge, MA, 02139, USA., Richards A; Moderna Inc., Cambridge, MA, 02139, USA., Green S; Moderna Inc., Cambridge, MA, 02139, USA., Nguyen B; Moderna Inc., Cambridge, MA, 02139, USA., King E; Moderna Inc., Cambridge, MA, 02139, USA., Ogega C; Moderna Inc., Cambridge, MA, 02139, USA., Russo L; Moderna Inc., Cambridge, MA, 02139, USA., Sen-Kilic E; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Plante O; Moderna Inc., Cambridge, MA, 02139, USA., Himansu S; Moderna Inc., Cambridge, MA, 02139, USA., Barbier M; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA., Carfi A; Moderna Inc., Cambridge, MA, 02139, USA., Damron FH; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, USA. fdamron@hsc.wvu.edu.; Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, WV, USA. fdamron@hsc.wvu.edu.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Jun 10; Vol. 9 (1), pp. 103. Date of Electronic Publication: 2024 Jun 10.

Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge.

Autor: Weaver KL; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Bitzer GJ; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Wolf MA; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Pyles GM; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., DeJong MA; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Dublin SR; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Huckaby AB; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Gutierrez MP; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Hall JM; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Wong TY; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Warden M; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Petty JE; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Witt WT; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Cunningham C; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Sen-Kilic E; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Damron FH; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America., Barbier M; Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America.

Publikováno v: PloS one [PLoS One] 2023 Nov 02; Vol. 18 (11), pp. e0286925. Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2023).

Long-Term Analysis of Pertussis Vaccine Immunity to Identify Potential Markers of Vaccine-Induced Memory Associated With Whole Cell But Not Acellular Pertussis Immunization in Mice.

Autor: Weaver KL; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Blackwood CB; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Horspool AM; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Pyles GM; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Sen-Kilic E; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Grayson EM; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Huckaby AB; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Witt WT; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., DeJong MA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Wolf MA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Damron FH; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States., Barbier M; Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, United States.; Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, WV, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Feb 08; Vol. 13, pp. 838504. Date of Electronic Publication: 2022 Feb 08 (Print Publication: 2022).

Reinvestigating the Coughing Rat Model of Pertussis To Understand Bordetella pertussis Pathogenesis.

Autor: Hall JM; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Kang J; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Kenney SM; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Wong TY; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Bitzer GJ; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Kelly CO; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Kisamore CA; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Boehm DT; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., DeJong MA; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Wolf MA; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Sen-Kilic E; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Horspool AM; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Bevere JR; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Barbier M; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA., Damron FH; Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia Universitygrid.268154.c, Morgantown, West Virginia, USA.; Vaccine Development Center, WVU Health Sciences Center, Morgantown, West Virginia, USA.

Publikováno v: Infection and immunity [Infect Immun] 2021 Nov 16; Vol. 89 (12), pp. e0030421. Date of Electronic Publication: 2021 Jun 14.