Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110).

Autor: Kivitz A; Altoona Center for Clinical Research, Duncansville, PA, USA., DeHaan W; Selecta Biosciences, Inc., Watertown, MA, USA., Azeem R; Selecta Biosciences, Inc., Watertown, MA, USA., Park J; Selecta Biosciences, Inc., Watertown, MA, USA., Rhodes S; Selecta Biosciences, Inc., Watertown, MA, USA., Inshaw J; Exploristics Ltd., Belfast, UK., Leung SS; Selecta Biosciences, Inc., Watertown, MA, USA., Nicolaou S; University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada., Johnston L; Selecta Biosciences, Inc., Watertown, MA, USA., Kishimoto TK; Selecta Biosciences, Inc., Watertown, MA, USA., Traber PG; Selecta Biosciences, Inc., Watertown, MA, USA. ptraber@selectabio.com., Sands E; Selecta Biosciences, Inc., Watertown, MA, USA., Choi H; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA.

Publikováno v: Rheumatology and therapy [Rheumatol Ther] 2023 Aug; Vol. 10 (4), pp. 825-847. Date of Electronic Publication: 2023 Apr 17.

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The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout.

Autor: Baraf HSB; Rheumatology, Center for Rheumatology and Bone Research, Wheaton, MD, USA.; Rheumatology, George Washington University, Washington DC, USA., Khanna PP; Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA., Kivitz AJ; Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, USA., Strand V; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA., Choi HK; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA., Terkeltaub R; Rheumatology, Allergy and Immunology Division, San Diego VA Healthcare Service and UCSD, San Diego, CA, USA., Dalbeth N; Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand., DeHaan W; Selecta Biosciences, Watertown, MA, USA., Azeem R; Selecta Biosciences, Watertown, MA, USA., Traber PG; Selecta Biosciences, Watertown, MA, USA., Keenan RT; Duke University School of Medicine, Durham, NC, USA.; Arthrosi Therapeutics, San Diego, CA, USA.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Apr 02; Vol. 63 (4), pp. 1058-1067.

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