Zobrazeno 1 - 10
of 13
pro vyhledávání: '"DeGuire SM"'
Autor:
Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland. hilal.lashuel@epfl.ch., Mahul-Mellier AL; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Novello S; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Hegde RN; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Jasiqi Y; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Altay MF; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Donzelli S; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., DeGuire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Burai R; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Magalhães P; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Ricci J; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Boussouf M; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Sadek A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland., Stoops E; ADx NeuroSciences, Technologiepark 94, Ghent, Belgium., Iseli C; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.; Bioinformatics Competence Center, University of Lausanne, 1015, Lausanne, Switzerland., Guex N; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.; Bioinformatics Competence Center, University of Lausanne, 1015, Lausanne, Switzerland.
Publikováno v:
NPJ Parkinson's disease [NPJ Parkinsons Dis] 2022 Oct 20; Vol. 8 (1), pp. 136. Date of Electronic Publication: 2022 Oct 20.
Autor:
Vieweg S; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Mahul-Mellier AL; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Ruggeri FS; Laboratory of the Physics of Living Matter, EPFL, 1015 Lausanne, Switzerland., Riguet N; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., DeGuire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Cendrowska U; Laboratory of the Physics of Living Matter, EPFL, 1015 Lausanne, Switzerland., Dietler G; Laboratory of the Physics of Living Matter, EPFL, 1015 Lausanne, Switzerland., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: hilal.lashuel@epfl.ch.
Publikováno v:
Journal of molecular biology [J Mol Biol] 2021 Oct 15; Vol. 433 (21), pp. 167222. Date of Electronic Publication: 2021 Sep 04.
Autor:
Cariulo C; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Verani M; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Martufi P; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Ingenito R; Peptide Chemistry Unit, IRBM S.p.A., Via Pontina Km 30 600, 00071, Pomezia, Rome, Italy., Finotto M; Peptide Chemistry Unit, IRBM S.p.A., Via Pontina Km 30 600, 00071, Pomezia, Rome, Italy., Deguire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Lavery DJ; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Toledo-Sherman L; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Lee R; CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA. Electronic address: ramee.lee@chdifoundation.org., Doherty EM; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Vogt TF; CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA., Dominguez C; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Petricca L; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Caricasole A; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy.
Publikováno v:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jan 15; Vol. 521 (3), pp. 549-554. Date of Electronic Publication: 2019 Oct 31.
Autor:
Cariulo C; Department of Neuroscience, IRBM S.p.A., Rome, Italy., Martufi P; Department of Neuroscience, IRBM S.p.A., Rome, Italy., Verani M; Department of Neuroscience, IRBM S.p.A., Rome, Italy., Azzollini L; Department of Neuroscience, IRBM S.p.A., Rome, Italy., Bruni G; IRBM Promidis, Rome, Italy., Weiss A; IRBM Promidis, Rome, Italy., Deguire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Scaricamazza E; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Sancesario GM; IRCCS Fondazione Santa Lucia, Rome, Italy., Schirinzi T; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Mercuri NB; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy.; IRCCS Fondazione Santa Lucia, Rome, Italy., Sancesario G; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Caricasole A; Department of Neuroscience, IRBM S.p.A., Rome, Italy., Petricca L; Department of Neuroscience, IRBM S.p.A., Rome, Italy.
Publikováno v:
Frontiers in neuroscience [Front Neurosci] 2019 Aug 22; Vol. 13, pp. 889. Date of Electronic Publication: 2019 Aug 22 (Print Publication: 2019).
Autor:
DeGuire SM; From the Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland and., Ruggeri FS; the Laboratory of the Physics of Living Matter, Institute of Physics of Biological Systems, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland., Fares MB; From the Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland and., Chiki A; From the Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland and., Cendrowska U; the Laboratory of the Physics of Living Matter, Institute of Physics of Biological Systems, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland., Dietler G; the Laboratory of the Physics of Living Matter, Institute of Physics of Biological Systems, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland., Lashuel HA; From the Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland and hilal.lashuel@epfl.ch.
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2018 Nov 30; Vol. 293 (48), pp. 18540-18558. Date of Electronic Publication: 2018 Sep 05.
Autor:
Cariulo C; Department of Neuroscience, IRBM Science Park, 00071 Pomezia, Rome, Italy., Azzollini L; Department of Neuroscience, IRBM Science Park, 00071 Pomezia, Rome, Italy., Verani M; Department of Neuroscience, IRBM Science Park, 00071 Pomezia, Rome, Italy., Martufi P; Department of Neuroscience, IRBM Science Park, 00071 Pomezia, Rome, Italy., Boggio R; IRBM Promidis, 00071 Pomezia, Rome, Italy., Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Deguire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Cherubini M; Departamento de Biomedicina, Facultad de Medicina, Instituto de Neurociencias, Universidad de Barcelona, 08035 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Gines S; Departamento de Biomedicina, Facultad de Medicina, Instituto de Neurociencias, Universidad de Barcelona, 08035 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Marsh JL; Department of Developmental and Cell Biology, University of California, Irvine, CA 92697., Conforti P; Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, 20122 Milan, Italy.; Istituto Nazionale Genetica Molecolare (INGM) Romeo ed Enrica Invernizzi, Milan 20122, Italy., Cattaneo E; Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, 20122 Milan, Italy.; Istituto Nazionale Genetica Molecolare (INGM) Romeo ed Enrica Invernizzi, Milan 20122, Italy., Santimone I; Huntington and Rare Diseases Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy., Squitieri F; Huntington and Rare Diseases Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland; hilal.lashuel@epfl.ch l.petricca@irbm.it a.caricasole@irbm.it., Petricca L; Department of Neuroscience, IRBM Science Park, 00071 Pomezia, Rome, Italy; hilal.lashuel@epfl.ch l.petricca@irbm.it a.caricasole@irbm.it., Caricasole A; Department of Neuroscience, IRBM Science Park, 00071 Pomezia, Rome, Italy; hilal.lashuel@epfl.ch l.petricca@irbm.it a.caricasole@irbm.it.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Dec 12; Vol. 114 (50), pp. E10809-E10818. Date of Electronic Publication: 2017 Nov 21.
Autor:
Daldin M; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Fodale V; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.; IRBM Promidis, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Cariulo C; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Azzollini L; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.; IRBM Promidis, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Verani M; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.; IRBM Promidis, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Martufi P; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Spiezia MC; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Deguire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Cherubini M; Departamento de Ciencias Biomedicas, Facultat de Medicina, Instituto de Neurociencias, Universitat de Barcelona, Barcelona, Spain., Macdonald D; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Weiss A; IRBM Promidis, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.; Evotec AG, Manfred Eigen Campus, Hamburg, Germany., Bresciani A; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Vonsattel JG; Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University Medical Center, 710 West 168th Street, New York, NY, 10032, USA., Petricca L; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.; IRBM Promidis, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy., Marsh JL; Department of Developmental and Cell Biology, University of California, Irvine, 92697, USA., Gines S; Departamento de Ciencias Biomedicas, Facultat de Medicina, Instituto de Neurociencias, Universitat de Barcelona, Barcelona, Spain., Santimone I; Huntington and Rare Diseases Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Marano M; Huntington and Rare Diseases Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Squitieri F; Huntington and Rare Diseases Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Caricasole A; IRBM Science Park, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy. a.caricasole@irbm.it.; IRBM Promidis, Via Pontina km 30.600, 00071, Pomezia, Rome, Italy. a.caricasole@irbm.it.
Publikováno v:
Scientific reports [Sci Rep] 2017 Jul 11; Vol. 7 (1), pp. 5070. Date of Electronic Publication: 2017 Jul 11.
Autor:
Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., DeGuire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Ruggeri FS; The Laboratory of the Physics of Living Matter, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland.; Current address: University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK., Sanfelice D; MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW71AA, UK., Ansaloni A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Wang ZM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Cendrowska U; The Laboratory of the Physics of Living Matter, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Burai R; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Vieweg S; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Pastore A; MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW71AA, UK., Dietler G; The Laboratory of the Physics of Living Matter, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-, 1015, Lausanne, Switzerland.
Publikováno v:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 May 02; Vol. 56 (19), pp. 5202-5207. Date of Electronic Publication: 2017 Mar 23.
Autor:
Chong KM; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Leelatian N; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Deguire SM; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Brockman AA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Earl D; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Ihrie RA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Irish JM; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Bachmann BO; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Sulikowski GA; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Publikováno v:
The Journal of antibiotics [J Antibiot (Tokyo)] 2016 Apr; Vol. 69 (4), pp. 327-30. Date of Electronic Publication: 2016 Mar 09.
Autor:
DeGuire SM; Department of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Nashville, TN 37232 (USA)., Earl DC, Du Y, Crews BA, Jacobs AT, Ustione A, Daniel C, Chong KM, Marnett LJ, Piston DW, Bachmann BO, Sulikowski GA
Publikováno v:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Jan 12; Vol. 54 (3), pp. 961-4. Date of Electronic Publication: 2014 Nov 27.