Bimodality in Ras signaling originates from processivity of the Ras activator SOS without deterministic bistability.

Autor: Lee AA; Department of Chemistry, University of California, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA., Kim NH; Department of Chemistry, University of California, Berkeley, CA 94720, USA., Alvarez S; Department of Chemistry, University of California, Berkeley, CA 94720, USA.; Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA., Ren H; Department of Chemistry, University of California, Berkeley, CA 94720, USA., DeGrandchamp JB; Department of Chemistry, University of California, Berkeley, CA 94720, USA., Lew LJN; Department of Chemistry, University of California, Berkeley, CA 94720, USA., Groves JT; Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Publikováno v: Science advances [Sci Adv] 2024 Jun 21; Vol. 10 (25), pp. eadi0707. Date of Electronic Publication: 2024 Jun 21.

A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane.

Autor: Lin CW; Department of Chemistry, University of California, Berkeley, CA 94720.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720., Nocka LM; Department of Chemistry, University of California, Berkeley, CA 94720.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720., Stinger BL; Department of Chemistry, University of California, Berkeley, CA 94720., DeGrandchamp JB; Department of Chemistry, University of California, Berkeley, CA 94720., Lew LJN; Department of Chemistry, University of California, Berkeley, CA 94720., Alvarez S; Department of Chemistry, University of California, Berkeley, CA 94720., Phan HT; Department of Chemistry, University of California, Berkeley, CA 94720., Kondo Y; Department of Chemistry, University of California, Berkeley, CA 94720.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720., Kuriyan J; Department of Chemistry, University of California, Berkeley, CA 94720.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720.; HHMI, Chevy Chase, MD 20815., Groves JT; Department of Chemistry, University of California, Berkeley, CA 94720.; Division of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, 639798 Singapore.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 10; Vol. 119 (19), pp. e2122531119. Date of Electronic Publication: 2022 May 04.