Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease.

Autor: Lercher A; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address: alercher@rockefeller.edu., Cheong JG; Department of Pathology and Laboratory Medicine, Laboratory of Epigenetics and Immunity, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA., Bale MJ; Department of Pathology and Laboratory Medicine, Laboratory of Epigenetics and Immunity, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA., Jiang C; Department of Pathology and Laboratory Medicine, Laboratory of Epigenetics and Immunity, Weill Cornell Medicine, New York, NY 10065, USA; BCMB Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA., Ashbrook AW; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA., Lewy T; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA., Yin YS; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA., Quirk C; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA., DeGrace EJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chiriboga L; Department of Pathology, New York University Medical Center, New York, NY 10016, USA; Center for Biospecimen Research and Development, New York, NY 10016, USA., Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Josefowicz SZ; Department of Pathology and Laboratory Medicine, Laboratory of Epigenetics and Immunity, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: szj2001@med.cornell.edu., Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address: ricec@rockefeller.edu.

Publikováno v: Immunity [Immunity] 2024 Nov 12; Vol. 57 (11), pp. 2530-2546.e13. Date of Electronic Publication: 2024 Sep 30.

Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation.

Autor: Torre D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for OncoGenomics and Innovative Therapeutics (COGIT), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Fstkchyan YS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ho JSY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore., Cheon Y; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Patel RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Degrace EJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mzoughi S; Center for OncoGenomics and Innovative Therapeutics (COGIT), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schwarz M; Center for OncoGenomics and Innovative Therapeutics (COGIT), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mohammed K; Center for OncoGenomics and Innovative Therapeutics (COGIT), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Seo JS; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Romero-Bueno R; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Demircioglu D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource Facility, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hasson D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource Facility, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Tang W; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Mahajani SU; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Campisi L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zheng S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Song WS; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Wang YC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Shah H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Francoeur N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Soto J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Salfati Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Weirauch MT; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Warburton P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Beaumont K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Smith ML; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA., Mulder L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Villalta SA; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697, USA., Kessenbrock K; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA., Jang C; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Lee D; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea., De Rubeis S; Seaver Autism Center for Research and Treatment, Department of Psychiatry, The Mindich Child Health and Development Institute, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cobos I; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Tam O; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Hammell MG; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Seldin M; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA., Shi Y; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA; Department of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA., Basu U; Department of Microbiology & Immunology, Columbia University Medical Center, New York, NY 10032, USA., Sebastiano V; Institute for Stem Cell Biology and Regenerative Medicine and the Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA., Byun M; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Benner C; Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA., Guccione E; Center for OncoGenomics and Innovative Therapeutics (COGIT), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: ernesto.guccione@mssm.edu., Marazzi I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA 92697, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: imarazzi@uci.edu.

Publikováno v: Molecular cell [Mol Cell] 2023 Dec 07; Vol. 83 (23), pp. 4255-4271.e9. Date of Electronic Publication: 2023 Nov 22.

Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single-cell RNA sequencing.

Autor: Cohen P; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., DeGrace EJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Danziger O; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Patel RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Barrall EA; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Bobrowski T; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Kehrer T; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Cupic A; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA., Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, New York, USA.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2023 Sep 07, pp. e0077623. Date of Electronic Publication: 2023 Sep 07.

Immunofluorescence-Mediated Detection of Respiratory Virus Infections in Human Airway Epithelial Cultures.

Autor: Gagliardi TB; Department of Cell Biology and Molecular Genetics, Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland., Iverson E; Department of Cell Biology and Molecular Genetics, Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland., DeGrace EJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York., Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York., Scull MA; Department of Cell Biology and Molecular Genetics, Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland.

Publikováno v: Current protocols [Curr Protoc] 2022 Jun; Vol. 2 (6), pp. e453.