Zobrazeno 1 - 10 of 161 pro vyhledávání: '"DeGoey DA"'
1
Akademický článek
Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro.
Autor: Kovar P; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Richardson PL; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Korepanova A; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Afanador GA; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Stojkovic V; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Li T; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Schrimpf MR; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Ng TI; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Degoey DA; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Gopalakrishnan SM; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA., Chen J; SMTPT, AbbVie Discovery, AbbVie, 1 N Waukegan Rd., North Chicago, IL 60065, USA. Electronic address: jun.chen@abbvie.com.
Publikováno v: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2024 Sep; Vol. 29 (6), pp. 100179. Date of Electronic Publication: 2024 Aug 14.
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2
Akademický článek
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain.
Autor: Patel MV; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA. Electronic address: meena.v.patel@abbvie.com., Peltier HM; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Matulenko MA; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Koenig JR; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., C Scanio MJ; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Gum RJ; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., El-Kouhen OF; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Fricano MM; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Lundgaard GL; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Neelands T; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Zhang XF; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Zhan C; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Pai M; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Ghoreishi-Haack N; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Hudzik T; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Gintant G; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Martin R; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., McGaraughty S; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Xu J; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Bow D; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Kalvass JC; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Kym PR; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., DeGoey DA; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA., Kort ME; AbbVie, Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, USA.
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Jun 01; Vol. 63, pp. 116743. Date of Electronic Publication: 2022 Apr 11.
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3
Akademický článek
Antiviral Drug Discovery for the Treatment of COVID-19 Infections.
Autor: Ng TI; Virology Drug Discovery, AbbVie Inc., North Chicago, IL 60064, USA., Correia I; Department of Cell and Protein Sciences, Drug Discovery Science and Technology, AbbVie Inc., Worcester, MA 01605, USA., Seagal J; Department of Biologics Discovery, Drug Discovery Science and Technology, AbbVie Inc., Worcester, MA 01605, USA., DeGoey DA; Department of Centralized Medicinal Chemistry, Drug Discovery Science and Technology, AbbVie Inc., North Chicago, IL 60064, USA., Schrimpf MR; Department of Centralized Medicinal Chemistry, Drug Discovery Science and Technology, AbbVie Inc., North Chicago, IL 60064, USA., Hardee DJ; Department of Centralized Medicinal Chemistry, Drug Discovery Science and Technology, AbbVie Inc., North Chicago, IL 60064, USA., Noey EL; Department of Structural Biology, Drug Discovery Science and Technology, AbbVie Inc., North Chicago, IL 60064, USA., Kati WM; Virology Drug Discovery, AbbVie Inc., North Chicago, IL 60064, USA.
Publikováno v: Viruses [Viruses] 2022 May 04; Vol. 14 (5). Date of Electronic Publication: 2022 May 04.
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4
Akademický článek
Implications of the Conformationally Flexible, Macrocyclic Structure of the First-Generation, Direct-Acting Anti-Viral Paritaprevir on Its Solid Form Complexity and Chameleonic Behavior.
Autor: Sheikh AY; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Mattei A; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Miglani Bhardwaj R; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Hong RS; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Abraham NS; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Schneider-Rauber G; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Engstrom KM; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Diwan M; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Henry RF; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Gao Y; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Juarez V; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Jordan E; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., DeGoey DA; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States., Hutchins CW; Research & Development, AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2021 Oct 27; Vol. 143 (42), pp. 17479-17491. Date of Electronic Publication: 2021 Oct 12.
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5
Akademický článek
Desymmetrization of pibrentasvir for efficient prodrug synthesis.
Autor: Voight EA; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., Greszler SN; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., Hartung J; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Ji J; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Klix RC; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Randolph JT; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., Shelat BH; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Waters JE; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., DeGoey DA; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com.
Publikováno v: Chemical science [Chem Sci] 2021 Jun 29; Vol. 12 (29), pp. 10076-10082. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
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6
Akademický článek
Nebulized inhalation of plasma-activated water in the treatment of progressive moderate COVID-19 patients with antiviral treatment failure: a randomized controlled pilot trial.
Autor: Zhao, Heng1 (AUTHOR), Meng, Wanting1 (AUTHOR), Lv, Xing1 (AUTHOR), Li, Jing1 (AUTHOR), Cai, Zhigui1 (AUTHOR), Guo, Xingxing1 (AUTHOR), Wang, Zifeng2 (AUTHOR), Guo, Li2 (AUTHOR), Rong, Mingzhe2 (AUTHOR), Shen, Cong3 (AUTHOR), Liu, Dingxin2 (AUTHOR) liudingxin@mail.xjtu.edu.cn, Song, Liqiang1 (AUTHOR) songlq@fmmu.edu.cn
Publikováno v: BMC Infectious Diseases. 9/12/2024, Vol. 24 Issue 1, p1-12. 12p.
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7
Akademický článek
Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530).
Autor: Randolph JT; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Greszler SN; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Uno BE; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Newton JN; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Gleason KM; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Stolarik D; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Van Handel C; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Bow DAJ; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., DeGoey DA; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 11034-11044. Date of Electronic Publication: 2020 Sep 17.
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8
Akademický článek
Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.
Autor: Randolph JT; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Li T; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Chris Krueger A; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Heyman HR; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Chen HJ; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Bow DAJ; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Van Handel C; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Peterkin V; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Carr RA; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Stolarik D; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Dekhtyar T; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Irvin M; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Krishnan P; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Wagner R; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., DeGoey DA; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Apr 01; Vol. 30 (7), pp. 126986. Date of Electronic Publication: 2020 Jan 25.
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9
Akademický článek
Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
Autor: Chris Krueger A; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States. Electronic address: a.chris.krueger@abbvie.com., Chen HJ; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States. Electronic address: hui-ju.chen@abbvie.com., Randolph JT; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Brown BS; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Halvorsen GT; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Heyman HR; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Li T; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Marvin CC; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Shanley JP; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Voight EA; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Bow DAJ; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Van Handel C; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Peterkin V; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Carr RA; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Stolarik D; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Dekhtyar T; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Irvin ML; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Krishnan P; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Henry RF; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., Wagner R; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States., DeGoey DA; AbbVie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Jan 01; Vol. 28 (1), pp. 115208. Date of Electronic Publication: 2019 Nov 11.
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10
Akademický článek
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.
Autor: DeGoey DA; Research and Development , AbbVie Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Chen HJ; Research and Development , AbbVie Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Cox PB; Research and Development , AbbVie Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Wendt MD; Research and Development , AbbVie Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Apr 12; Vol. 61 (7), pp. 2636-2651. Date of Electronic Publication: 2017 Sep 27.
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