A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner.

Autor: Boltz TA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Chu BB; Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Liao C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sealock JM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ye R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Majara L; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry and Mental Health and South African Medical Council Research Unit on Risk and Resilience in Mental Disorders, Neuroscience Institute, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa., Fu JM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Service S; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA., Zhan L; Department of Psychiatry, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.; The Collaboratory, Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Chapman SB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA., Rubinacci S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School,, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School,, Boston, MA, USA., DeFelice M; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Grimsby JL; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abebe T; Department of Microbiology, Immunology, and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Alemayehu M; Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Ashaba FK; Department of Immunology & Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda., Atkinson EG; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Bigdeli T; Institute for Genomics in Health, The State University of New York, Brooklyn, NY, USA., Bradway AB; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brand H; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Chibnik LB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Fekadu A; Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.; Centre for Innovative Drug Development & Therapeutic Trials for Africa, Addis Ababa University, Addis Ababa, Ethiopia., Gatzen M; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gelaye B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School and The Chester M. Pierce MD, Division of Global Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Gichuru S; Department of Mental Health, Moi Teaching and Referral Hospital, Eldoret, Kenya., Gildea ML; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hill TC; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA., Hubbard KM; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Injera WE; Department of Medical Laboratory Sciences, School of Health Sciences, Alupe University, Busia, Kenya., James R; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Joloba M; School of Biomedical Sciences, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Kachulis C; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kalmbach PR; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kamulegeya R; School of Biomedical Sciences, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Kigen G; Department of Pharmacology and Toxicology, Moi University School of Medicine, Eldoret, Kenya., Kim S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Koen N; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.; SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town and Neuroscience Institute, Cape Town, South Africa., Kwobah EK; Department of Mental Health, Moi Teaching and Referral Hospital, Eldoret, Kenya., Kyebuzibwa J; Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Lee S; Department of Computer Science, University of California Los Angeles, Los Angeles, CA, USA., Lennon NJ; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lind PA; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Lopera-Maya EA; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Makale J; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme-Coast, Kilifi, Kenya., Mangul S; Department of Quantitative and Computational Biology, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.; Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy, University of Southern California, Los Angeles, CA, USA., McMahon J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Mowlem P; Ampath Laboratories, Moi University School of Medicine, Eldoret, Kenya., Musinguzi H; Department of Immunology & Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda., Mwema RM; Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast,, Kilifi, Kenya., Nakasujja N; Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Newman CP; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Nkambule LL; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., O'Neil CR; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Olivares AM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Olsen CM; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Ongeri L; Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya., Parsa SJ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Pretorius A; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Ramesar R; SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town and Neuroscience Institute, Cape Town, South Africa., Reagan FL; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sabatti C; Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA., Schneider JA; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shiferaw W; Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Stevenson A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Stricker E; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Stroud RE 2nd; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Tang J; Broad Clinical Labs (BCL), Broad Institute of MIT and Harvard, Cambridge, MA, USA., Whiteman D; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Yohannes MT; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Yu M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yuan K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Akena D; Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Atwoli L; Department of Mental Health and Behavioural Sciences, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya.; Brain and Mind Institute, The Aga Khan University, Nairobi, Kenya.; Department of Medicine, Medical College East Africa, The Aga Khan University, Nairobi, Kenya., Kariuki SM; Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast, Kilifi, Kenya.; Department of Psychiatry, University of Oxford, Oxford, UK., Koenen KC; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Newton CRJC; Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast,, Kilifi, Kenya.; Department of Psychiatry, University of Oxford, Oxford, UK., Stein DJ; SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town and Neuroscience Institute, Cape Town, South Africa., Teferra S; Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Zingela Z; Executive Dean's Office, Faculty of Health Sciences, Nelson Mandela University, Gqebera, South Africa., Pato CN; Rutgers University, New Brunswick, NJ, USA.; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA., Pato MT; Rutgers University, New Brunswick, NJ, USA.; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA., Lopez-Jaramillo C; Department of Psychiatry, University of Antioquia, University of Antioquia, Medellín, Antioquia, Colombia., Freimer N; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Ophoff RA; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Olde Loohuis LM; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Talkowski ME; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Neale BM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA., Howrigan DP; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Martin AR; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; BD2: Breakthrough Discoveries for thriving with Bipolar Disorder, Santa Monica, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 08. Date of Electronic Publication: 2024 Sep 08.

Sharing Data from the Human Tumor Atlas Network through Standards, Infrastructure, and Community Engagement.

Autor: de Bruijn I, Nikolov M, Lau C, Clayton A, Gibbs DL, Mitraka E, Pozhidayeva D, Lash A, Sumer SO, Altreuter J, Anton K, DeFelice M, Li X, Lisman A, R Longabaugh WJ, Muhlich J, Santagata S, Nandakumar S, Sorger PK, Suver C, Schultz N, Taylor AJ, Thorsson V, Cerami E, Eddy JA

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 30. Date of Electronic Publication: 2024 Jun 30.

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A second generation human haplotype map of over 3.1 million SNPs

Autor: Frazer, KA, Ballinger, DG, Cox, DR, Hinds, DA, Stuve, LL, Gibbs, RA, Belmont, JW, Boudreau, A, Hardenbol, P, Leal, SM, Pasternak, S, Wheeler, DA, Willis, TD, Yu, F, Yang, H, Zeng, C, Gao, Y, Hu, H, Hu, W, Li, C, Lin, W, Liu, S, Pan, H, Tang, X, Wang, J, Wang, W, Yu, J, Zhang, B, Zhang, Q, Zhao, H, Zhou, J, Gabriel, SB, Barry, R, Blumenstiel, B, Camargo, A, Defelice, M, Faggart, M, Goyette, M, Gupta, S, Moore, J, Nguyen, H, Onofrio, RC, Parkin, M, Roy, J, Stahl, E, Winchester, E, Ziaugra, L, Altshuler, D, Shen, Y, Yao, Z, Huang, W, Chu, X, He, Y, Jin, L, Liu, Y, Sun, W, Wang, H, Wang, Y, Xiong, X, Xu, L, Waye, MM, Tsui, SK, Xue, H, Wong, JT, Galver, LM, Fan, JB, Gunderson, K, Murray, SS, Oliphant, AR, Chee, MS, Montpetit, A, Chagnon, F, Ferretti, V, Leboeuf, M, Olivier, JF, Phillips, MS, Roumy, S, Sallée, C, Verner, A, Hudson, TJ, Kwok, PY, Cai, D, Koboldt, DC, Miller, RD, Pawlikowska, L, Taillon-Miller, P, Xiao, M, Tsui, LC, Mak, W, Song, YQ, Tam, PK, Nakamura, Y, Kawaguchi, T, Kitamoto, T, Morizono, T, Nagashima, A, Ohnishi, Y, Sekine, A, Tanaka, T, Tsunoda, T, Deloukas, P, Bird, CP, Delgado, M, Dermitzakis, ET, Gwilliam, R, Hunt, S, Morrison, J, Powell, D, Stranger, BE, Whittaker, P, Bentley, DR, Daly, MJ, de Bakker, PI, Barrett, J, Chretien, YR, Maller, J, McCarroll, S, Patterson, N, Pe'er, I, Price, A, Purcell, S, Richter, DJ, Sabeti, P, Saxena, R, Schaffner, SF, Sham, PC, Varilly, P, Stein, LD, Krishnan, L, Smith, AV, Tello-Ruiz, MK, Thorisson, GA, Chakravarti, A, Chen, PE, Cutler, DJ, Kashuk, CS, Lin, S, Abecasis, GR, Guan, W, Li, Y, Munro, HM, Qin, ZS, Thomas, DJ, McVean, G, Auton, A, Bottolo, L, Cardin, N, Eyheramendy, S, Freeman, C, Marchini, J, Myers, S, Spencer, C, Stephens, M, Donnelly, P, Cardon, LR, Clarke, G, Evans, DM, Morris, AP, Weir, BS, Mullikin, JC, Sherry, ST, Feolo, M, Skol, A, Zhang, H, Matsuda, I, Fukushima, Y, Macer, DR, Suda, E, Rotimi, CN, Adebamowo, CA, Ajayi, I, Aniagwu, T, Marshall, PA, Nkwodimmah, C, Royal, CD, Leppert, MF, Dixon, M, Peiffer, A, Qiu, R, Kent, A, Kato, K, Niikawa, N, Adewole, IF, Knoppers, BM, Foster, MW, Clayton, EW, Watkin, J, Muzny, D, Nazareth, L, Sodergren, E, Weinstock, GM, Yakub, I, Birren, BW, Wilson, RK, Fulton, LL, Rogers, J, Burton, J, Carter, NP, Clee, CM, Griffiths, M, Jones, MC, McLay, K, Plumb, RW, Ross, MT, Sims, SK, Willey, DL, Chen, Z, Han, H, Kang, L, Godbout, M, Wallenburg, JC, L'Archevêque, P, Bellemare, G, Saeki, K, An, D, Fu, H, Li, Q, Wang, Z, Wang, R, Holden, AL, Brooks, LD, McEwen, JE, Guyer, MS, Wang, VO, Peterson, JL, Shi, M, Spiegel, J, Sung, LM, Zacharia, LF, Collins, FS, Kennedy, K, Jamieson, R, Stewart, J

We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc69d5467446013e06f8e6b3ce330a21
https://ora.ox.ac.uk/objects/uuid:31fded11-b4a3-4eca-b227-9d67121ace10

A low-fat amino acid diet reverses intestinal failure and shows good growth trends in five infants with diacylglycerol transferase 1 (DGAT1) deficiency: a prospective cohort study.

Autor: Zheng, Yuanyuan¹ (AUTHOR), Li, Yongzhen^2,3 (AUTHOR), Zheng, Cuifang⁴ (AUTHOR), Yang, Lin⁵ (AUTHOR), Zhang, Chongfan⁶ (AUTHOR), Huang, Ying⁴ (AUTHOR), Wang, Yuhuan⁴ (AUTHOR), Qian, Tian¹ (AUTHOR) drqiantian@fudan.edu.cn

Publikováno v: Lipids in Health & Disease. 11/15/2024, Vol. 23 Issue 1, p1-9. 9p.