Zobrazeno 1 - 10
of 65
pro vyhledávání: '"DeCrescenzo, Gary A."'
Autor:
Andrea Wang-Gillam, Ernest Trevino, Sarina Anne Piha-Paul, Halle H. Zhang, Khashayarsha Khazaie, Amanda Collins, Tyler Masters, Mark Klang, Thorunn Helgason, Daniel D. Karp, Sanjay Goel, David Tung, Ronald L. Korn, Alexey A. Leontovich, Brent Kreider, Filip Janku, Mary Varterasian, Saurabh Saha, Divya Sakamuri, Maria Miller, David S. Hong, Anjali Raina, Jennifer L. Salstrom, Jean Torrisi, Decrescenzo Gary A, Alice S. Weissfeld, Linping Zhang, Dale R. Shepard, Abdul Mohammad Pezeshki, Stephen B. Solomon, Mrinal M. Gounder, Steven Y. Huang, Ravi Murthy
Publikováno v:
Clinical Cancer Research. 27:96-106
Purpose: Intratumorally injected Clostridium novyi-NT (nontoxic; lacking the alpha toxin), an attenuated strain of C. novyi, replicates within hypoxic tumor regions resulting in tumor-confined cell lysis and inflammatory response in animals, which wa
Autor:
DeCrescenzo, Gary A.
Publikováno v:
Retrospective Theses and Dissertations.
This report discusses research in three areas of organic synthesis: The synthesis of potential insecticides; the reinvestigation of the reaction of hexamethylphosphoramide with ketoximes; and the regioselective fluoroalkoxylation and polyfluoroalkoxy
Akademický článek
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Autor:
Xiaoyan M. Zhang, Enrique Zudaire, Brad St. Croix, Karen Morris, Jennifer Hwang, Dean Welsch, Guojun Yu, James M. Dunleavey, Yang Feng, Steven Seaman, Diana C. Haines, Decrescenzo Gary A, Saurabh Saha, Kuo Sheng Hsu, Zhongyu Zhu, Mary Beth Hilton, Christopher S. Szot, Dimiter S. Dimitrov, Deborah A. Swing, Yanping Wang, Amit Chaudhary, Holly Morris
Publikováno v:
Journal of Clinical Investigation. 128:2927-2943
Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for improved cancer therapy are needed. Here, we describe a potent MMAE-linked antibody-drug conjugat
Autor:
Diane M. Boucher, David Sorrell, Kathryn R. Meshaw, Dean Welsch, Michael J. Wick, William Markland, Alex Aronov, Saurabh Saha, Matthew J. Fitzgibbon, Mark N. Namchuk, Ramin Samadani, Gabriel Martinez-Botella, Michael R. Hale, Ursula A. Germann, Caroline Emery, Brinley Furey, Russell R. Hoover, Decrescenzo Gary A, Paul Shapiro, Anna L. Groover, Jeffrey James Roix
Publikováno v:
Molecular Cancer Therapeutics. 16:2351-2363
Aberrant activation of signaling through the RAS–RAF–MEK–ERK (MAPK) pathway is implicated in numerous cancers, making it an attractive therapeutic target. Although BRAF and MEK-targeted combination therapy has demonstrated significant benefit b
Autor:
James W. Mier, Dean Welsch, Anthony W. Tolcher, Antoni Ribas, Andrea Wang-Gillam, Filip Janku, Caroline Emery, Jeffrey A. Sosman, Keith T. Flaherty, Mario E. Lacouture, Anna L. Groover, Mario Sznol, Geoffrey I. Shapiro, Richard D. Carvajal, Decrescenzo Gary A, Anna M. Varghese, Ryan J. Sullivan, Bob T. Li, Jeffrey R. Infante, Vicki L. Keedy, Sapna Pradyuman Patel, Manish R. Patel, Deborah Jean Lee Wong, David M. Hyman, Elizabeth I. Buchbinder, Mary Varterasian, Saurabh Saha
Publikováno v:
Cancer discovery. 8(2)
Ulixertinib (BVD-523) is an ERK1/2 kinase inhibitor with potent preclinical activity in BRAF- and RAS-mutant cell lines. In this multicenter phase I trial (NCT01781429), 135 patients were enrolled to an accelerated 3 + 3 dose-escalation cohort and si
Autor:
David Tung, Decrescenzo Gary A, Dean Welsch, Peter H. Cheung, Chetan Bettegowda, Saurabh Saha
Publikováno v:
World Journal of Microbiology and Biotechnology. 30:3003-3010
The nucleoside analogue, 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) is a substrate for thymidine kinase (TK), which is commonly expressed in bacteria. It is currently being investigated in clinical studies as an in vivo bacterial i
Autor:
Sylvia Degrado, Kimberly D. Klarmann, Dimiter S. Dimitrov, Julia Scheiermann, Brad St. Croix, Zhongyu Zhu, Dmitry Borkin, Yang Feng, Steven Seaman, Mi Young Yang, Enrique Zudaire, Holly Morris, Yanping Wang, Nareshkumar F. Jain, Karen Morris, Jinyu Li, Mary Beth Hilton, Sean W. Smith, Jonathan R. Keller, Lino Tessarollo, Saurabh Saha, Christopher S. Szot, Amit Chaudhary, Deborah A. Swing, Xiaoyan M. Zhang, Decrescenzo Gary A, Dean Welsch
Publikováno v:
Cancer cell. 31(4)
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonst
Autor:
Alexey A. Leontovich, Khashayarsha Khazaie, Mary Varterasian, Brent Kreider, Abdul Mohammad Pezeshki, Ravi Murthy, David S. Hong, Dale R. Shepard, Anjali Raina, Decrescenzo Gary A, Halle H. Zhang, Andrea Wang-Gillam, Mrinal M. Gounder, Filip Janku, Sarina Anne Piha-Paul, David Tung
Publikováno v:
Cancer Immunology Research. 7:A011-A011
Bacteriolytic strategies offer unique advantages to combat a broad range of cancers often refractive to conventional chemotherapies and/or radiotherapies. C. novyi-NT is an attenuated strain of Clostridium novyi, a spore-forming, gram-positive, oblig
Akademický článek
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