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Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.

Autor: Hamdouchi C; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Maiti P; Jubilant Biosys Research Center , Bangalore, India., Warshawsky AM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., DeBaillie AC; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Otto KA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Wilbur KL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Kahl SD; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Patel Lewis A; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Cardona GR; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Zink RW; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Chen K; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Cr S; Jubilant Biosys Research Center , Bangalore, India., Lineswala JP; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Neathery GL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Bouaichi C; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Diseroad BA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Campbell AN; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Sweetana SA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Adams LA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Cabrera O; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Ma X; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Yumibe NP; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Montrose-Rafizadeh C; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Chen Y; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States., Miller AR; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center , DC: 0540, Indianapolis, Indiana 46285, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 934-945. Date of Electronic Publication: 2018 Jan 05.