Zobrazeno 1 - 10
of 20
pro vyhledávání: '"De-Yan Hou"'
Autor:
David H. Munn, George C. Prendergast, Andrew L. Mellor, Maribeth Johnson, Tinku Banerjee, James DuHadaway, Madhav D. Sharma, Alexander J. Muller, De-Yan Hou
Indoleamine 2,3-dioxygenase (IDO) is an immunosuppressive enzyme that contributes to tolerance in a number of biological settings. In cancer, IDO activity may help promote acquired tolerance to tumor antigens. The IDO inhibitor 1-methyl-tryptophan is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a58189dd959aa9b31bb36d3809e404e
https://doi.org/10.1158/0008-5472.c.6495032.v1
https://doi.org/10.1158/0008-5472.c.6495032.v1
Autor:
Babak Baban, Phillip Chandler, De Yan Hou, Andrew L. Mellor, Levi Makala, Ahmed El-Awady, David H. Munn, Henrique Lemos
Publikováno v:
The Journal of Infectious Diseases. 203:715-725
Inflammation stimulates immunity but can create immune privilege in some settings. Here, we show that cutaneous Leishmania major infection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa513f251c6528b370ceaa5d11e0f930
https://doi.org/10.1093/infdis/jiq095
https://doi.org/10.1093/infdis/jiq095
Autor:
Bruce R. Blazar, Babak Baban, Hideo Yagita, Andrew L. Mellor, Nagendra Singh, Miyuki Azuma, De Yan Hou, Madhav D. Sharma, David H. Munn, Phillip Chandler
Publikováno v:
Journal of Clinical Investigation. 117:2570-2582
A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO+ pDCs directly activate resting CD4+CD25+Foxp3+ Tregs for potent suppressor ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c70bf3540fff454db834dfe38406674
https://doi.org/10.1172/jci31911
https://doi.org/10.1172/jci31911
Autor:
Madhav D. Sharma, Andrew L. Mellor, Alexander J. Muller, George C. Prendergast, David H. Munn, De Yan Hou, Maribeth H. Johnson, James B. DuHadaway, Tinku Banerjee
Publikováno v:
Cancer Research. 67:792-801
Indoleamine 2,3-dioxygenase (IDO) is an immunosuppressive enzyme that contributes to tolerance in a number of biological settings. In cancer, IDO activity may help promote acquired tolerance to tumor antigens. The IDO inhibitor 1-methyl-tryptophan is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a2dd4d2917282ef15fbf17cd81fe01
https://doi.org/10.1158/0008-5472.can-06-2925
https://doi.org/10.1158/0008-5472.can-06-2925
Autor:
Yukai He, Babak Baban, David H. Munn, De Yan Hou, Pandelakis A. Koni, Phillip Chandler, Andrew L. Mellor, Madhav D. Sharma, Bruce R. Blazar
Publikováno v:
Immunity. 33(6)
Summary Foxp3 + regulatory T (Treg) cells can undergo reprogramming into a phenotype expressing proinflammatory cytokines. However, the biologic significance of this conversion remains unclear. We show that large numbers of Treg cells undergo rapid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fea8758bf077928acc84a31a5083ca2
https://pubmed.ncbi.nlm.nih.gov/21554089
https://pubmed.ncbi.nlm.nih.gov/21554089
Publikováno v:
Journal of Surgical Oncology. 51:236-242
A new 111Indium labeled bleomycin complex (111In-BLMC) was prepared and found to be effective for tumor imaging and therapy both in mouse glioma and human small cell lung cancer (SCLC) cells. Chromosome aberrations were studied in human SCLC cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da124a8a913d899099e77675eb2a16f5
https://doi.org/10.1002/jso.2930510407
https://doi.org/10.1002/jso.2930510407
Autor:
Yosh Maruyama, De-Yan Hou
Publikováno v:
Journal of Surgical Oncology. 49:93-97
The distribution of 111 In-bleomycin Complex (111In-BLMC) in small cell lung cancer (SCLC) cells was studied by autoradiography. SCLC cells were exposed to 111In-BLMC and 111Indium chloride (111InCl3) for 1 hour, 3 hours, and 4 hours; washed with fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2398d6106d3a0364d32e8a6c877bfdd
https://doi.org/10.1002/jso.2930490206
https://doi.org/10.1002/jso.2930490206
Autor:
Andrew L. Mellor, Madhav D. Sharma, Pandelakis A. Koni, Yukai He, Yanjun Liu, De Yan Hou, Richard Metz, David H. Munn, Phillip Chandler
Publikováno v:
Blood. 113(24)
The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining lymph nodes (TDLNs), where it can potently activate Foxp3+ regulatory T cells (Tregs). We now show that IDO fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820a21ec007cd194d7e9bdbda1b7d0fa
https://pubmed.ncbi.nlm.nih.gov/19366986
https://pubmed.ncbi.nlm.nih.gov/19366986
Autor:
De-Yan Hou, Yosh Maruyama
Publikováno v:
Journal of surgical oncology. 44(1)
Indium-111-bleomycin complex ({sup 111}In-BLMC) is a radiopharmaceutical agent that produces tumor regression in mouse glioma in vivo and kills human small cell lung cancer (SCLC) cells in vitro. The interaction between hyperthermia and {sup 111}In-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ff540cf758fa5eca4889edfe4b13b9
https://pubmed.ncbi.nlm.nih.gov/1692949
https://pubmed.ncbi.nlm.nih.gov/1692949
Publikováno v:
Radiation Research. 128:282
The problem of determining RBE values for Auger emitters incorporated into proliferating mammalian cells is examined. In general, the reference radiation plays a key role in obtaining experimental RBE values. Using survival of cultured Chinese hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dde80910533748db27dd0fbd1bdb27d
https://doi.org/10.2307/3578051
https://doi.org/10.2307/3578051