Zobrazeno 1 - 10
of 246
pro vyhledávání: '"De-Chen Lin"'
Autor:
Yuan Jiang, Yueyuan Zheng, Yuan-Wei Zhang, Shuai Kong, Jinxiu Dong, Fei Wang, Benjamin Ziman, Sigal Gery, Jia-Jie Hao, Dan Zhou, Jianian Zhou, Allen S. Ho, Uttam K. Sinha, Jian Chen, Shuo Zhang, Chuntong Yin, Dan-Dan Wei, Masaharu Hazawa, Huaguang Pan, Zhihao Lu, Wen-Qiang Wei, Ming-Rong Wang, H. Phillip Koeffler, De-Chen Lin, Yan-Yi Jiang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low response rate and treatment resis
Externí odkaz:
https://doaj.org/article/cf7285deb31c4f9bae07734dca4386f3
Autor:
Benjamin Ziman, Qian Yang, Yueyuan Zheng, Megha Sheth, Chehyun Nam, Hua Zhao, Le Zhang, Boyan Hu, Neil A. Bhowmick, Uttam K. Sinha, De-Chen Lin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-12 (2024)
Abstract Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using whole genome bisulfite sequencing (WGBS), we identify the transcription factor (TF) FOXM1 as an
Externí odkaz:
https://doaj.org/article/8c6da2f863444d0c9674c0754368f7a4
Autor:
Young Min Park, De-Chen Lin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant transcriptional heterogeneity, intercellular communication, and organization of microanatomical structures within the tumor microenvironment. This technical break
Externí odkaz:
https://doaj.org/article/bbdad40225414f6889c994fe09d53cc3
Autor:
Yueyuan Zheng, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, H Phillip Koeffler, Benjamin P. Berman, De-Chen Lin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-31 (2023)
Abstract Background As one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from distinct cells-of-origin. Distinguishing cell-type-specific molecular features from cancer-specif
Externí odkaz:
https://doaj.org/article/6b59f1cedad94224a5e59061095d1407
Autor:
Yuan Jiang, Hua Zhao, Shuai Kong, Dan Zhou, Jinxiu Dong, Yulan Cheng, Shuo Zhang, Fei Wang, Andrew Kalra, Nina Yang, Dan-Dan Wei, Jian Chen, Yuan-Wei Zhang, De-Chen Lin, Stephen J. Meltzer, Yan-Yi Jiang
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/e53e842f3d464acb9618de35373ff6c9
Autor:
Wenwen Chien, Jeffrey W. Tyner, Sigal Gery, Yueyuan Zheng, Li-Yan Li, Mohan Shankar Gopinatha Pillai, Chehyun Nam, Neil A. Bhowmick, De-Chen Lin, H. Phillip Koeffler
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background Standard platinum-based therapy for ovarian cancer is inefficient against ovarian clear cell carcinoma (OCCC). OCCC is a distinct subtype of epithelial ovarian cancer. OCCC constitutes 25% of ovarian cancers in East Asia (Japan, K
Externí odkaz:
https://doaj.org/article/085f030e8b1144f18f14b1e5bcb913e7
Autor:
De-Chen Lin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Esophageal cancers feature distinct manifestations between and within patients which complicate precision diagnosis, prognosis, and patient care. New genomic and epigenomic research uncovers novel mechanisms underlying both inter- and intra-tumoral h
Externí odkaz:
https://doaj.org/article/4ee852d1e7d848108f9d2b82972a55b8
Autor:
Le Zhang, Yueyuan Zheng, Wenwen Chien, Benjamin Ziman, Sandrine Billet, H. Phillip Koeffler, De-Chen Lin, Neil A. Bhowmick
Publikováno v:
Cancers, Vol 15, Iss 22, p 5377 (2023)
ARID1A, a member of the chromatin remodeling SWI/SNF complex, is frequently lost in many cancer types, including esophageal adenocarcinoma (EAC). Here, we study the impact of ARID1A deficiency on the anti-tumor immune response in EAC. We find that EA
Externí odkaz:
https://doaj.org/article/528d9206b84940d583e41306da8ecfcd
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5309-5315 (2022)
Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin. Recently, substantial advances have been made in applying genetically engineered organoid mode
Externí odkaz:
https://doaj.org/article/c39a9e05be9546fb930c7d1be19b8ea8
Autor:
Huy Q. Dinh, Feng Pan, Geng Wang, Qing-Feng Huang, Claire E. Olingy, Zhi-Yong Wu, Shao-Hong Wang, Xin Xu, Xiu-E Xu, Jian-Zhong He, Qian Yang, Sandra Orsulic, Marcela Haro, Li-Yan Li, Guo-Wei Huang, Joshua J. Breunig, H. Phillip Koeffler, Catherine C. Hedrick, Li-Yan Xu, De-Chen Lin, En-Min Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The microenvironment of oesophageal squamous cell carcinomas (ESCC) is heterogeneous and can strongly impact response to treatment. Here, the authors characterize the ESCC tumour microenvironment with single-cell RNA-seq, finding CST1 + myofibroblast
Externí odkaz:
https://doaj.org/article/2e80dc52b5e14a5c9cab19a0f4a82e35