Chemical synthesis of quillaic acid, the aglycone of QS-21

Autor: Jin-Xi Liao, Zhi-Yong Zeng, Jian-Song Sun, Qing-Ju Zhang, Zhen-Ni Hu, De-Yong Liu

Publikováno v: Organic Chemistry Frontiers. 8:748-753

With the easily available protoescigenin as a starting material, a protocol to chemically synthesize quillaic acid was established. Benefiting from the scalability of each step comprising the novel protocol, the route featured robustness. Moreover, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd9723ec26e7fd01105d72fb210c0059
https://doi.org/10.1039/d0qo01356k

Synthetic Investigation toward QS-21 Analogues

Autor: Qing-Ju Zhang, Zhen-Ni Hu, Zhi-Yong Zeng, Jin-Xi Liao, Jian-Song Sun, De-Yong Liu

Publikováno v: Organic Letters. 22:8613-8617

With glycosyl o-alkynylbenzotes as donors, a highly efficient protocol to construct the challenging glycosidic linkages at C3-OH of C23-oxo oleanane triterpenoids is disclosed, on the basis of which different strategies for the highly efficient synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e2090cb5033ef4566da5917885e105
https://doi.org/10.1021/acs.orglett.0c03185

1-Picolinyl-5-azido Thiosialosides: Versatile Donors for the Stereoselective Construction of Sialyl Linkages

Autor: De Yong Liu, Jian Chen, Yao Sun, Qing Ju Zhang, Thomas Hansen, Jeroen D. C. Codée, Jian-Song Sun, Richard R. Schmidt, Hao Yan

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie. International Edition, 58(47), 17000-17008. Wiley
Chen, J, Hansen, T, Zhang, Q J, Liu, D Y, Sun, Y, Yan, H, Codée, J D C, Schmidt, R R & Sun, J S 2019, ' 1-Picolinyl-5-azido Thiosialosides: Versatile Donors for the Stereoselective Construction of Sialyl Linkages ', Angewandte Chemie. International Edition, vol. 58, no. 47, pp. 17000-17008 . https://doi.org/10.1002/anie.201909177

With the picolinyl (Pic) group as a C-1 located directing group and N3 as versatile precursor for C5-NH2, a novel 1-Pic-5-N3 thiosialyl donor was designed and synthesized, based on which a new sialylation protocol was established. In comparison to co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da65b97de99b4132dd51ae464048546e
https://doi.org/10.1002/anie.201909177

Copper-Catalyzed Four-Component Reaction for the Synthesis ofN-Difluoroethyl Imides

Autor: Gao Yu, Peng Shanqing, Xiang-Guo Hu, Pei-Xin Rui, De-Yong Liu

Publikováno v: European Journal of Organic Chemistry. 2019:1715-1721

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55b35223bfa4a59b6129090a952ed8ed
https://doi.org/10.1002/ejoc.201801334

Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

Autor: Wen-Li Hu, De-Yong Liu, Xiang-Guo Hu, Zheng Fang, Chu-Yi Yu

Publikováno v: Green Chemistry. 19:1299-1302

An efficient and green procedure for the synthesis of tetrazines has been developed based on an old chemistry reported by Carboni in 1958. Both symmetric and asymmetric 3,6-disubstituted 1,2,4,5-tetrazines can be obtained in moderate to high yields f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe48cb92792f4cb5f142784a55701062
https://doi.org/10.1039/c6gc03494b