HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer.

Autor: Kalisz M; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London, UK.; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain.; CIBERONC, Madrid, Spain., Bernardo E; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain., Beucher A; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London, UK., Maestro MA; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain., Del Pozo N; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain.; CIBERONC, Madrid, Spain., Millán I; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain.; CIBERONC, Madrid, Spain., Haeberle L; Institute of Pathology, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany., Schlensog M; Institute of Pathology, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany., Safi SA; Department of Surgery, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany., Knoefel WT; Department of Surgery, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany., Grau V; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain., de Vas M; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London, UK., Shpargel KB; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Vaquero E; CiberEHD, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, IDIBAPS, Barcelona, Spain., Magnuson T; Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ortega S; Transgenics Unit, Spanish National Cancer Research Centre-CNIO, Madrid, Spain., Esposito I; Department of Surgery, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany., Real FX; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain.; CIBERONC, Madrid, Spain.; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain., Ferrer J; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London, UK.; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain.

Publikováno v: The EMBO journal [EMBO J] 2020 May 04; Vol. 39 (9), pp. e102808. Date of Electronic Publication: 2020 Mar 10.

Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis.

Autor: Quilichini E; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Fabre M; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Dirami T; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Stedman A; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., De Vas M; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Ozguc O; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Pasek RC; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Cereghini S; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Morillon L; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France., Guerra C; Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain., Couvelard A; Hôpital Bichat, Département de Pathologie, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France., Gannon M; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Haumaitre C; UMR7622 Sorbonne Université, Centre National de la Recherche Scientifique, Institut de Biologie Paris-Seine, Paris, France. Electronic address: cecile.haumaitre@inserm.fr.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2019; Vol. 8 (3), pp. 487-511. Date of Electronic Publication: 2019 Jun 21.

O65 Rôle essentiel d’HNF1B/MODY5 dans le contrôle des progéniteurs pancréatiques

Autor: Haumaitre, C., De Vas, M., Kopp, J., Sander, M., Cereghini, S.

Publikováno v: In Diabetes and Metabolism 26-29 March 2013 39 Supplement 1:A16-A16

Acinar-to-Ductal Metaplasia (ADM): On the Road to Pancreatic Intraepithelial Neoplasia (PanIN) and Pancreatic Cancer.

Autor: Marstrand-Daucé, Louis¹ (AUTHOR) louis.marstrand-dauce@etu.u-paris.fr, Lorenzo, Diane¹ (AUTHOR) diane.lorenzo@inserm.fr, Chassac, Anaïs^1,2 (AUTHOR) anais.chassac@aphp.fr, Nicole, Pascal¹ (AUTHOR) pascal.nicole@inserm.fr, Couvelard, Anne^1,2 (AUTHOR) anne.couvelard@aphp.fr, Haumaitre, Cécile¹ (AUTHOR) cecile.haumaitre@inserm.fr

Publikováno v: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 12, p9946. 21p.

Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer.

Autor: Li, Xiaojia^1,2 (AUTHOR), He, Jie³ (AUTHOR), Xie, Keping^1,2 (AUTHOR) scutmedicine@scut.edu.cn

Publikováno v: Cellular Oncology (2211-3428). Apr2022, Vol. 45 Issue 2, p201-225. 25p.