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pro vyhledávání: '"De Val S"'
The complex and hierarchical vascular network of arteries, veins, and capillaries features considerable endothelial heterogeneity, yet the regulatory pathways directing arteriovenous specification, differentiation and identity are still not fully und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::50e8fce4bc907c99d9eafb4f600038e2
https://ora.ox.ac.uk/objects/uuid:07ed36f8-d034-4282-9d74-f0dbb58651a8
https://ora.ox.ac.uk/objects/uuid:07ed36f8-d034-4282-9d74-f0dbb58651a8
Publikováno v:
Developmental Dynamics.
Transcription factors play a crucial role in regulating the dynamic and precise patterns of gene expression required for the initial specification of endothelial cells (ECs), and during endothelial growth and differentiation. Whilst sharing many core
Autor:
Souilhol, C, Tardajos Ayllon, B, Li, X, Diagbouga, MR, Zhou, Z, Canham, L, Roddie, H, Pirri, D, Chambers, EV, Dunning, MJ, Ariaans, M, Li, J, Fang, Y, Jørgensen, HF, Simons, M, Krams, R, Waltenberger, J, Fragiadaki, M, Ridger, V, De Val, S, Francis, SE, Chico, TJA, Serbanovic-Canic, J, Evans, PC
Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arteries that causes heart attack and stroke, through poorly defined mechanisms. The Notch pathway plays a central role in blood vessel growth and homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b23f9ed0fb742ab6ea4e485343238
https://www.repository.cam.ac.uk/handle/1810/341580
https://www.repository.cam.ac.uk/handle/1810/341580
Akademický článek
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Autor:
Nicola Smart, Dorota Szumska, Jacinta I. Kalisch-Smith, Joaquim M. Vieira, Morris Ec, Andia N. Redpath, J.E. Outhwaite, De Val S, Konstantinos Klaourakis, Paul R. Riley, Strevens Ma, Duncan B. Sparrow
Placental vascular gene networks in mammals have been largely unexplored due to a lack of well validated molecular markers to identify them. This is required to study how they form in development, and how they are impacted by embryonic or maternal de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c02258c8fd11696fc8608cc956df3d
https://doi.org/10.1101/2021.05.06.442902
https://doi.org/10.1101/2021.05.06.442902
Akademický článek
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Autor:
Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S.
Publikováno v:
Nature Communications
Nature communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, sugge
Autor:
Sacilotto, N, Chouliaras, K M, Nikitenko, L L, Lu, Y W, Fritzsche, M, Wallace, M D, Nornes, S, García-Moreno, F, Payne, S, Bridges, E, Liu, K, Biggs, D, Ratnayaka, I, Herbert, S P, Molnár, ZP, Harris, A L, Davies, B, Bond, G L, Bou-Gharios, G, Schwarz, J J, De Val, S
Publikováno v:
Sacilotto, N, Chouliaras, K, Nikitenko, L, Wei Lu, Y, fritzsche, M, Wallace, M, Nornes, S, García-Moreno, F, payne, S, Bridges, E, Liu, K, Biggs, D, Ratnayaka, I, Herbert, S, Molnár, Z, Harris, A, Davies, B, Bond, G, Bou-Gharios, G, Schwarz, J & De Val, S 2016, ' MEF2 transcription factors are key regulators of sprouting angiogenesis ', Genes and development, vol. 30, no. 20, pp. 2297-2309 . https://doi.org/10.1101/gad.290619.116
GENES & DEVELOPMENT
GENES & DEVELOPMENT
Angiogenesis, the fundamental process by which new blood vessels form from existing ones, depends on precise spatial and temporal gene expression within specific compartments of the endothelium. However, the molecular links between proangiogenic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5d6ede0d11cf9fdeee936b62b8b9c025
https://www.research.manchester.ac.uk/portal/en/publications/mef2-transcription-factors-are-key-regulators-of-sprouting-angiogenesis(970956c8-ee5b-4d34-af1b-251090778fa1).html
https://www.research.manchester.ac.uk/portal/en/publications/mef2-transcription-factors-are-key-regulators-of-sprouting-angiogenesis(970956c8-ee5b-4d34-af1b-251090778fa1).html
Akademický článek
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Autor:
Becker, PW, Sacilotto, N, Nornes, S, Neal, A, Thomas, MO, Liu, K, Preece, C, Ratnayaka, I, Davies, B, Bou-Gharios, G, De Val, S
Publikováno v:
Arteriosclerosis, Thrombosis and Vascular Biology
Objective—The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous