Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity.

Autor: Lamoot A; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium., Jangra S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Laghlali G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Warang P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chang LA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Park SC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, 54596, South Korea., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., De Swarte K; Laboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent University, Ghent, 9000, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, 9000, Belgium.; Department of Respiratory Medicine, Ghent University Hospital, Ghent, 9000, Belgium., Zhong Z; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium., Louage B; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium., De Lombaerde E; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium., Ye T; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium., Chen Y; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium., Cuadrado-Castano S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Lienenklaus S; Institute for Laboratory Animal Science and Institute of Immunology, Hannover Medical School, 30625, Hannover, Germany., Sanders NN; Laboratory of Gene Therapy, Ghent University, Merelbeke, 9820, Belgium., Lambrecht BN; Laboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent University, Ghent, 9000, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, 9000, Belgium.; Department of Respiratory Medicine, Ghent University Hospital, Ghent, 9000, Belgium., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., De Geest BG; Department of Pharmaceutics, Ghent University, Ghent, 9000, Belgium.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Mar; Vol. 20 (10), pp. e2306892. Date of Electronic Publication: 2023 Oct 22.