Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

Autor: Luth MR; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Godinez-Macias KP; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Chen D; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Okombo J; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Thathy V; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Cheng X; Global Health Drug Discovery Institute, Beijing, China., Daggupati S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Davies H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Dhingra SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Economy JM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Edgar RCS; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Gomez-Lorenzo MG; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Istvan ES; Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Jado JC; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., LaMonte GM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Melillo B; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Mok S; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Narwal SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Ndiaye T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Ottilie S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Palomo Diaz S; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Park H; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Peña S; Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Montevideo, Uruguay., Rocamora F; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Sakata-Kato T; Global Health Drug Discovery Institute, Beijing, China.; Department of Protozoology, Nekken Institute for Tropical Medicine, Nagasaki University, Nagasaki, Japan., Small-Saunders JL; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Summers RL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Vanaerschot M; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Xia G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., You A; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Gamo FJ; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Goldberg DE; Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., McNamara CW; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA., Ndiaye D; Centre International de Recherche et de Formation en Génomique Appliquée et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Rosenthal PJ; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Schreiber SL; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Serra G; Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Montevideo, Uruguay., De Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Skinner-Adams TS; Institute for Biomedicine and Glycomics and School of Environment and Science, Griffith University, Nathan, QLD, Australia., Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kato N; Global Health Drug Discovery Institute, Beijing, China.; Department of Protozoology, Nekken Institute for Tropical Medicine, Nagasaki University, Nagasaki, Japan., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Winzeler EA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov 29; Vol. 386 (6725), pp. eadk9893. Date of Electronic Publication: 2024 Nov 29.

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.

Autor: Mellott DM; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Tseng CT; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Drelich A; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Fajtová P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic., Chenna BC; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Kostomiris DH; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Hsu J; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Zhu J; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Taylor ZW; Department of Chemistry, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843.; Current address: Biological Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, WA 99353., Tat V; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Katzfuss A; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Li L; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Giardini MA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Skinner D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Hirata K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Beck S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Carlin AF; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA., Clark AE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Beretta L; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Maneval D; Selva Therapeutics, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Frueh F; Selva Therapeutics, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Hurst BL; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Wang H; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Kocurek KI; Department of Chemistry, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Raushel FM; Department of Chemistry, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Meek TD; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Oct 30. Date of Electronic Publication: 2020 Oct 30.

Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection.

Autor: McCall LI; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States., Morton JT; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States., Bernatchez JA; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States., Knight R; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States., McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, ‡Department of Computer Science, §Department of Pediatrics, ∥Center for Microbiome Innovation, and ⊥Collaborative Mass Spectrometry Innovation Center, University of California San Diego , La Jolla, California 92093, United States.

Publikováno v: Analytical chemistry [Anal Chem] 2017 Oct 03; Vol. 89 (19), pp. 10414-10421. Date of Electronic Publication: 2017 Sep 22.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Autor: Fonseca NC; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., da Cruz LF; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., da Silva Villela F; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., do Nascimento Pereira GA; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, Brazil., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA., Kellar D; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., Suzuki BM; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., Ray D; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., de Souza TB; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Alves RJ; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Sales Júnior PA; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil., Romanha AJ; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Murta SM; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil., McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA., Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., de Oliveira RB; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Ferreira RS; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil rafaelasf@icb.ufmg.br.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 May; Vol. 59 (5), pp. 2666-77. Date of Electronic Publication: 2015 Feb 23.

LaTBP1: a Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain.

Autor: Lira CB; Departamento de Genética, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Botucatu 18618-000, SP, Brazil., de Siqueira Neto JL, Khater L, Cagliari TC, Peroni LA, dos Reis JR, Ramos CH, Cano MI

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2007 Sep 15; Vol. 465 (2), pp. 399-409. Date of Electronic Publication: 2007 Jun 29.