Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

Autor: Luth MR; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Godinez-Macias KP; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Chen D; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Okombo J; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Thathy V; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Cheng X; Global Health Drug Discovery Institute, Beijing, China., Daggupati S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Davies H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Dhingra SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Economy JM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Edgar RCS; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., Gomez-Lorenzo MG; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Istvan ES; Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Jado JC; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., LaMonte GM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Melillo B; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Mok S; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Narwal SK; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Ndiaye T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., Ottilie S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Palomo Diaz S; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Park H; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Peña S; Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Montevideo, Uruguay., Rocamora F; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Sakata-Kato T; Global Health Drug Discovery Institute, Beijing, China.; Department of Protozoology, Nekken Institute for Tropical Medicine, Nagasaki University, Nagasaki, Japan., Small-Saunders JL; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Summers RL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Vanaerschot M; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Xia G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA., You A; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Gamo FJ; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Goldberg DE; Department of Internal Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK., McNamara CW; Calibr, a division of The Scripps Research Institute, La Jolla, CA, USA., Ndiaye D; Centre International de Recherche et de Formation en Génomique Appliquée et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Rosenthal PJ; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Schreiber SL; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Serra G; Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Montevideo, Uruguay., De Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Skinner-Adams TS; Institute for Biomedicine and Glycomics and School of Environment and Science, Griffith University, Nathan, QLD, Australia., Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kato N; Global Health Drug Discovery Institute, Beijing, China.; Department of Protozoology, Nekken Institute for Tropical Medicine, Nagasaki University, Nagasaki, Japan., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Winzeler EA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov 29; Vol. 386 (6725), pp. eadk9893. Date of Electronic Publication: 2024 Nov 29.

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.

Autor: Mellott DM, Tseng CT; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Drelich A; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Fajtová P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic., Chenna BC, Kostomiris DH, Hsu J; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Zhu J, Taylor ZW, Kocurek KI, Tat V; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Katzfuss A, Li L, Giardini MA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Skinner D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Hirata K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Yoon MC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Beck S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Carlin AF; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California 92037, United States., Clark AE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Beretta L; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Maneval D, Hook V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Meek TD, McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2021 Apr 16; Vol. 16 (4), pp. 642-650. Date of Electronic Publication: 2021 Mar 31.

High Throughput and Computational Repurposing for Neglected Diseases.

Autor: Hernandez HW; KAL Research Initiatives LLC, Houston, Texas, 77042, USA. helenwhernandez@kalresearchinitiatives.com., Soeung M; MD Anderson Cancer Center, University of Texas, Houston, Texas, USA., Zorn KM; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA., Ashoura N; University of Texas at Austin, Austin, Texas, USA., Mottin M; LabMol - Laboratory for Molecular Modeling and Drug Design Faculdade de Farmacia, Universidade Federal de Goias - UFG, Goiânia, GO, 74605-170, Brazil., Andrade CH; LabMol - Laboratory for Molecular Modeling and Drug Design Faculdade de Farmacia, Universidade Federal de Goias - UFG, Goiânia, GO, 74605-170, Brazil., Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, 92093, USA., de Siqueira-Neto JL; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, 92093, USA., Ekins S; Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA. sean@collaborationspharma.com.

Publikováno v: Pharmaceutical research [Pharm Res] 2018 Dec 17; Vol. 36 (2), pp. 27. Date of Electronic Publication: 2018 Dec 17.

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease.

Autor: Kwakye-Nuako, Godwin^1,2 (AUTHOR), Middleton, Caitlyn E.³ (AUTHOR), McCall, Laura-Isobel^1,3 (AUTHOR) lmccall@sdsu.edu

Publikováno v: PLoS Pathogens. 3/8/2024, Vol. 20 Issue 3, p1-24. 24p.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Autor: Fonseca NC; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., da Cruz LF; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., da Silva Villela F; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., do Nascimento Pereira GA; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, Brazil., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA., Kellar D; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., Suzuki BM; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., Ray D; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., de Souza TB; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Alves RJ; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Sales Júnior PA; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil., Romanha AJ; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Murta SM; Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil., McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, USA., Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases and Department of Pathology, University of California, San Francisco, San Francisco, California, USA., de Oliveira RB; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Ferreira RS; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil rafaelasf@icb.ufmg.br.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 May; Vol. 59 (5), pp. 2666-77. Date of Electronic Publication: 2015 Feb 23.