Spheroid Drug Sensitivity Screening in Glioma Stem Cell Lines.

Autor: Harvey K; Division of Oncology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; School of Medicine, University of Pennsylvania., Labella K; Division of Oncology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; School of Medicine, University of Pennsylvania., Liou A; Division of Oncology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; School of Medicine, University of Pennsylvania., Brosius S; Division of Oncology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; School of Medicine, University of Pennsylvania., De Raedt T; Division of Oncology, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania; School of Medicine, University of Pennsylvania; deraedtt@chop.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2024 Feb 02 (204). Date of Electronic Publication: 2024 Feb 02.

Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas.

Autor: Dougherty J; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Harvey K; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Liou A; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Labella K; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Moran D; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Brosius S; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Department or Neurology, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America., De Raedt T; Department of Pediatrics, Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.; School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Publikováno v: PloS one [PLoS One] 2023 Feb 02; Vol. 18 (2), pp. e0277305. Date of Electronic Publication: 2023 Feb 02 (Print Publication: 2023).

Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.

Autor: Coy S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Wang S; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Harvard Graduate Program in Biophysics, Harvard University, Boston, MA, USA., Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lin JR; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Yapp C; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Ritch CC; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA., Salhi L; Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Epinière, and AP-HP Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Paris, France., Baker GJ; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Rashid R; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Pitt-CMU Medical Scientist Training Program, University of Pittsburgh-Carnegie Mellon, Pittsburgh, PA, USA., Baquer G; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Regan M; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Khadka P; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cole KA; Children's Hospital of Philadelphia, University of Pennsylvania, Pennsylvania, PA, USA., Hwang J; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wen PY; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bandopadhayay P; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Santi M; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., De Raedt T; Children's Hospital of Philadelphia, University of Pennsylvania, Pennsylvania, PA, USA., Ligon KL; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sorger PK; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Touat M; Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Epinière, and AP-HP Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Paris, France. mehdi.touat@aphp.fr.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mehdi.touat@aphp.fr., Santagata S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ssantagata@bics.bwh.harvard.edu.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Boston, MA, USA. ssantagata@bics.bwh.harvard.edu.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. ssantagata@bics.bwh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Aug 16; Vol. 13 (1), pp. 4814. Date of Electronic Publication: 2022 Aug 16.

Proof of Concept for Genome Profiling of the Neurofibroma/Sarcoma Sequence in Neurofibromatosis Type 1.

Autor: Cannizzaro, Ilenia Rita¹ (AUTHOR), Treccani, Mirko^1,2 (AUTHOR), Taiani, Antonietta¹ (AUTHOR), Ambrosini, Enrico³ (AUTHOR), Busciglio, Sabrina¹ (AUTHOR), Cesarini, Sofia¹ (AUTHOR), Luberto, Anita¹ (AUTHOR), De Sensi, Erika¹ (AUTHOR), Moschella, Barbara¹ (AUTHOR), Gismondi, Pierpacifico⁴ (AUTHOR), Azzoni, Cinzia⁵ (AUTHOR), Bottarelli, Lorena⁵ (AUTHOR), Giordano, Giovanna⁵ (AUTHOR), Corradi, Domenico⁵ (AUTHOR), Silini, Enrico Maria⁵ (AUTHOR), Zanatta, Valentina⁶ (AUTHOR), Cennamo, Federica⁷ (AUTHOR), Bertolini, Patrizia⁷ (AUTHOR), Caggiati, Patrizia³ (AUTHOR), Martorana, Davide³ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10822. 18p.

Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity.

Autor: Zhang Y; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Guillermier C; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., De Raedt T; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Cox AG; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Maertens O; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Yimlamai D; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Boston, MA, USA., Lun M; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA., Whitney A; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA., Maas RL; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Goessling W; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Cichowski K; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Ludwig Center, Dana-Farber/Harvard Cancer Center, Boston, MA, USA., Steinhauser ML; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: msteinhauser@pitt.edu.

Publikováno v: IScience [iScience] 2020 Aug 21; Vol. 23 (8), pp. 101355. Date of Electronic Publication: 2020 Jul 10.