Zobrazeno 1 - 10
of 193
pro vyhledávání: '"De Pover, A."'
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 60K, Linear correlation observed between tumor growth inhibition (% T/C) or tumor regression and the fraction of time over the in vivo S473P-Akt IC80 in different cancer cell line-derived tumor xenografts implanted in nude mice (represented as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c451963b6c78f1e12fd0af2cb9344
https://doi.org/10.1158/1535-7163.22500847.v1
https://doi.org/10.1158/1535-7163.22500847.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 504K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5217e68bb6f66bf8de1b2c62617ded0d
https://doi.org/10.1158/1535-7163.22498663.v1
https://doi.org/10.1158/1535-7163.22498663.v1
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that selective inhibition of PI3Kα may have robust efficacy in PIK3CA-mutant cancers while sparing patients the side-effects associated with broader inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1880b1b9abb1f6035e8d18e36185fc
https://doi.org/10.1158/1535-7163.c.6536590.v1
https://doi.org/10.1158/1535-7163.c.6536590.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1c96f82771189e532e391627afa78
https://doi.org/10.1158/2159-8290.22528301.v1
https://doi.org/10.1158/2159-8290.22528301.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 11K, Activity of NVP-BBT594 in biochemical and cell-based assays. The IC50 (mean of two experiments) of NVP-BBT594 on the JAK2 kinase was determined in a biochemical kinase assay with the active enzyme. Half-maximal growth inhibition (GI50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31418f731a67ae71f974979b4eddf70
https://doi.org/10.1158/2159-8290.22528298
https://doi.org/10.1158/2159-8290.22528298
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 215K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3161654c306e2ce8d66e45bce9aaecf3
https://doi.org/10.1158/1535-7163.22498672.v1
https://doi.org/10.1158/1535-7163.22498672.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 579K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d026bfb2fc2e7457d371cee0b78835a
https://doi.org/10.1158/1535-7163.22498660.v1
https://doi.org/10.1158/1535-7163.22498660.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 766K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6175ca243884319c53cf4dbb36b3e7
https://doi.org/10.1158/1535-7163.22498669.v1
https://doi.org/10.1158/1535-7163.22498669.v1
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 129K, Legends for Supplementary Figures 1 through 4 and Supplementary Tables 1 through 7. Supplementary Table 1. Determination of NVP-BYL719 in vitro effects on human protein kinases. Supplementary Table 2. Activity profile of NVP-BYL719 in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295e1f6fc6768a196f59f54ff9ba1231
https://doi.org/10.1158/1535-7163.22500844.v1
https://doi.org/10.1158/1535-7163.22500844.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 253K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66363ecd7075929bc17d05b673341d7c
https://doi.org/10.1158/1535-7163.22498675.v1
https://doi.org/10.1158/1535-7163.22498675.v1