LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Autor: Flahault, Adrien, Keck, Mathilde, Girault-Sotias, Pierre-Emmanuel, Esteoulle, Lucie, de Mota, Nadia, Bonnet, Dominique, Llorens-Cortes, Catherine

Publikováno v: Frontiers in Pharmacology, Frontiers, 2021, 12

Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a systemical

Externí odkaz: http://arxiv.org/abs/2211.04115

QGC606: A Best-in-Class Orally Active Centrally Acting Aminopeptidase A Inhibitor Prodrug for Treating Heart Failure Following Myocardial Infarction

Autor: Boitard, Solène E., Keck, Mathilde, Deloux, Robin, Girault-Sotias, Pierre-Emmanuel, Marc, Yannick, De Mota, Nadia, Compere, Delphine, Agbulut, Onnik, Balavoine, Fabrice, Llorens-Cortes, Catherine

Publikováno v: In Canadian Journal of Cardiology June 2022 38(6):815-827

Apelin, a Potent Diuretic Neuropeptide Counteracting Vasopressin Actions through Inhibition of Vasopressin Neuron Activity and Vasopressin Release

Autor: De Mota, Nadia, Goazigo, Annabelle Reaux-Le, El Messari, Said, Chartrel, Nicolas, Roesch, Darren, Dujardin, Cynthia, Kordon, Claude, Vaudry, Hubert, Moos, Françoise, Llorens-Cortes, Catherine, Hökfelt, Tomas

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2004 Jul . 101(28), 10464-10469.

Externí odkaz: https://www.jstor.org/stable/3372914

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Autor: Flahault, Adrien, Keck, Mathilde, Girault-Sotias, Pierre-Emmanuel, Esteoulle, Lucie, De Mota, Nadia, Bonnet, Dominique, Llorens-Cortes, Catherine

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.715095⟩
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Frontiers, 2021, 12, ⟨10.3389/fphar.2021.715095⟩

International audience; Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e93ebf9ab63f03cca0cc122471d2079
https://hal.science/hal-03322968/document

Activating the apelin receptor with LIT01-196, a metabolically stable apelin analog, reverses AVP-induced antidiuresis and hyponatremia

Autor: Flahault, Adrien, Girault-Sotias, Pierre-Emmanuel, Keck, Mathilde, Alvear-Perez, Rodrigo, De Mota, Nadia, Estéoulle, Lucie, Ramanoudjame, Sridévi, Iturrioz, Xavier, Bonnet, Dominique, Llorens-Cortes, Catherine

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-020-20560-y⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20560-y⟩

International audience; Abstract Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R) with LIT01-196, a metabolically stable apelin-17 analog, may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ba002acbe665dd0e6a9efe2717c1721c
https://hal.archives-ouvertes.fr/hal-03285794