Preparation and cytotoxicity of cisplatin-containing liposomes

Autor: Carvalho Júnior, A.D., Vieira, F.P., De Melo, V.J., Lopes, M.T.P., Silveira, J.N., Ramaldes, G.A., Garnier-Suillerot, A., Pereira-Maia, E.C., De Oliveira, M.C.

Publikováno v: Brazilian Journal of Medical and Biological Research v.40 n.8 2007
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 40, Iss 8, Pp 1149-1157 (2007)
Brazilian Journal of Medical and Biological Research, Volume: 40, Issue: 8, Pages: 1149-1157, Published: 14 JUN 2007

We encapsulated cisplatin into stealth pH-sensitive liposomes and studied their stability, cytotoxicity and accumulation in a human small-cell lung carcinoma cell line (GLC4) and its resistant subline (GLC4/CDDP). Since reduced cellular drug accumula

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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800017

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