The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis

Autor: Campbell, Grant R. ^{‡, §}, Pasquier, Eddy ^‡, Watkins, Jennifer ^{‡, ¶}, Bourgarel-Rey, Veronique ^‡, Peyrot, Vincent ^‡, Esquieu, Didier ^‡, Barbier, Pascale ^‡, de Mareuil, Jean ^‡, Braguer, Diane ^‡, Kaleebu, Pontiano ^∥, Yirrell, David L. ^{∥, **}, Loret, Erwann P. ^{‡, ‡‡}

Publikováno v: In Journal of Biological Chemistry 12 November 2004 279(46):48197-48204

Tat HIV-1 Primary and Tertiary Structures Critical to Immune Response Against Non-homologous Variants

Autor: Opi, Sandrine ^{‡, §}, Péloponèse, Jean-Marie, Jr. ^¶, Esquieu, Didier ^‡, Campbell, Grant ^{‡, ‖}, de Mareuil, Jean ^‡, Walburger, Anne ^‡, Solomiac, Murielle ^‡, Grégoire, Catherine ^‡, Bouveret, Emmanuelle ^‡, Yirrell, David L. ^{**, ‡}, Loret, Erwann P. ^{‡, §§}

Publikováno v: In Journal of Biological Chemistry 27 September 2002 277(39):35915-35919

HIV-1 Tat protein enhances Microtubule polymerization

Autor: Prevot Charles, Watkins Jennifer D, Esquieu Didier, Opi Sandrine, Lancelot Sophie, Campbell Grant R, Barbier Pascale, Carre Manon, de Mareuil Jean, Braguer Diane, Peyrot Vincent, Loret Erwann P

Publikováno v: Retrovirology, Vol 2, Iss 1, p 5 (2005)

Abstract Background HIV infection and progression to AIDS is characterized by the depletion of T cells, which could be due, in part, to apoptosis mediated by the extra-cellular HIV-encoded Tat protein as a consequence of Tat binding to tubulin. Micro

Externí odkaz: https://doaj.org/article/5e31c1ffcdee4b6fa14a423d52b3803f

A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor

Autor: Montembault, Mickaël, Vo-Thanh, Giang, Deyine, Abdallah, Fargeas, Valérie, Villiéras, Monique, Adjou, Ané, Dubreuil, Didier, Esquieu, Didier, Grégoire, Catherine, Opi, Sandrine, Péloponèse, Jean, Campbell, Grant, Watkins, Jennifer, de Mareuil, Jean, Aubertin, Anne-Marie, Bailly, Christian, Loret, Erwann, Lebreton, Jacques, Peloponese, Jean-Marie

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2004, 14 (6), pp.1543-1546. ⟨10.1016/j.bmcl.2003.12.095⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2004, 14 (6), pp.1543-1546. ⟨10.1016/j.bmcl.2003.12.095⟩

International audience; The HIV-1 Tat protein is a promising target for AIDS therapy, due to its extra-cellular roles against the immune system. From the 2D-NMR structure of Tat, we have designed molecules, called TDS, able to bind to Tat and inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec9d9571d6874e68a39521c6b273e9f
https://hal.science/hal-02137964

Fusogenic Determinants of Highly Cytopathic Subtype D Zairian isolate HIV-1 NDK

Autor: De Mareuil, Jean, Salaun, Danièle, Chermann, Jean-Claude, Hirsch, Ivan

Publikováno v: Virology; June 1995, Vol. 209 Issue: 2 p649-653, 5p