A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration

Autor: De Luca G. 1, Russo M.T. 1, Degan P. 2, Tiveron C. 3, Zijno A. 1, Meccia E. 1, Ventura I. 1, Mattei E. 4, Nakabeppu Y. 5, Crescenzi M. 1, Pepponi R. 6, Pezzola A. 6, Popoli P. 6, Bignami M. 1.

Publikováno v: PLOS genetics 4(11) (2008): 1–14.
info:cnr-pdr/source/autori:De Luca G. 1#; Russo M.T. 1#; Degan P. 2; Tiveron C. 3; Zijno A. 1; Meccia E. 1; Ventura I. 1; Mattei E. 4; Nakabeppu Y. 5; Crescenzi M. 1; Pepponi R. 6; Pezzola A. 6; Popoli P. 6; Bignami M. 1./titolo:A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration/doi:/rivista:PLOS genetics/anno:2008/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume:4(11)

Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons. This can occur either through direct oxidation of DNA guanine or via incorporation of the oxidized n

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https://publications.cnr.it/doc/4888