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Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Autor: Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Clevers, H.C., Gros, P., Crystal and Structural Chemistry, Sub Crystal and Structural Chemistry, Dep Biologie

Publikováno v: Cell Reports
Cell Reports, 3(6), 1885-1892. Cell Press
Cell Reports, Vol 3, Iss 6, Pp 1885-1892 (2013)
Cell Reports [E], 3(6), 1885. Elsevier Saunders

SummaryLeucine-rich repeat-containing G protein-coupled receptors 4–6 (LGR4–LGR6) are receptors for R-spondins, potent Wnt agonists that exert profound trophic effects on Wnt-driven stem cells compartments. We present crystal structures of a sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf82134ba1f7728f3c68a72fd844c743

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structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of Its receptor

Autor: 1) Peng, W.C, de Lau, W, Forneris, F, Granneman, J.C.M, Huch, M, Clevers, H. and Gros, P., 1) Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.

Publikováno v: Cell report.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::38d07b49443db838023ce5a4ab4a5980

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Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling

Autor: Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P., Crystal and Structural Chemistry, Sub Crystal and Structural Chemistry, Dep Biologie

Publikováno v: PLoS ONE
PLoS One, 8(12). Public Library of Science
PLoS ONE, Vol 8, Iss 12, p e83110 (2013)
'PloS One ', vol: 8, pages: e83110-1-e83110-10 (2013)

Zinc RING finger 3 (ZNRF3) and its homolog RING finger 43 (RNF43) antagonize Wnt signaling in adult stem cells by ubiquitinating Frizzled receptors (FZD), which leads to endocytosis of the Wnt receptor. Conversely, binding of ZNRF3/RNF43 to LGR4-6 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a8a586e1ef105bee0b3a057521d648

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Susceptibility of malignant plasma cells to HA-1H specific lysis suggests a role for the minor histocompatibility antigen HA-1 in the graft-versus-myeloma effect [3]

Autor: Holloway, P. A., Kaldenhoven, N., van Dijk, M., Bloem, A. C., de Lau, W., van der Zee, Ruurd, Kircher-Eibl, B., Mutis, T., Lokhorst, H. M.

Publikováno v: Leukemia, 18(9), 1543-1545. Nature Publishing Group
Holloway, P A, Kaldenhoven, N, van Dijk, M, Bloem, A C, de Lau, W, van der Zee, R, Kircher-Eibl, B, Mutis, T & Lokhorst, H M 2004, ' Susceptibility of malignant plasma cells to HA-1 H specific lysis suggests a role for the minor histocompatibility antigen HA-1 in the graft-versus-myeloma effect [3] ', Leukemia, vol. 18, no. 9, pp. 1543-1545 . https://doi.org/10.1038/sj.leu.2403445

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4f1c4ebd5267e9dd02e0d936c93249b5
https://research.vumc.nl/en/publications/181d2ec8-15f7-42f2-adec-340fdb899c90

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