Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Autor: Hobbs, BD, de Jong, K, Lamontagne, M, Bossé, Y, Shrine, N, Artigas, MS, Wain, LV, Hall, IP, Jackson, VE, Wyss, AB, London, SJ, North, KE, Franceschini, N, Strachan, DP, Beaty, TH, Hokanson, JE, Crapo, JD, Castaldi, PJ, Chase, RP, Bartz, TM, Heckbert, SR, Psaty, BM, Gharib, SA, Zanen, P, Lammers, JW, Oudkerk, M, Groen, HJ, Locantore, N, Tal-Singer, R, Rennard, SI, Vestbo, J, Timens, W, Paré, PD, Latourelle, JC, Dupuis, J, O'Connor, GT, Wilk, JB, Kim, WJ, Lee, MK, Oh, Y-M, Vonk, JM, de Koning, HJ, Leng, S, Belinsky, SA, Tesfaigzi, Y, Manichaikul, A, Wang, X-Q, Rich, SS, Barr, RG, Sparrow, D, Litonjua, AA, Bakke, P, Gulsvik, A, Lahousse, L, Brusselle, GG, Stricker, BH, Uitterlinden, AG, Ampleford, EJ, Bleecker, ER, Woodruff, PG, Meyers, DA, Qiao, D, Lomas, DA, Yim, J-J, Kim, DK, Hawrylkiewicz, I, Sliwinski, P, Hardin, M, Fingerlin, TE, Schwartz, DA, Postma, DS, MacNee, W, Tobin, MD, Silverman, EK, Boezen, HM, Cho, MH, COPDGene Investigators, ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium

Publikováno v: Nature Genetics

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::834c3a21a0c01477de684e2e7b49ebc3
https://openaccess.sgul.ac.uk/id/eprint/108399/7/NG-LE43518R_main_paper.pdf

Large-scale randomized prostate cancer screening trials: program performances in the European Randomized Screening for Prostate Cancer trial and the Prostate, Lung, Colorectal and Ovary cancer trial

Autor: de Koning, HJ, Auvinen, A, Berenguer Sanchez, A, Calais da Silva, F, Ciatto, S, Denis, L, Gohagan, JK, Hakama, M, Hugosson, J, Kranse, R, Nelen, V, Prorok, PC, Schröder, FH

Two large-scale randomized screening trials, the Prostate, Lung, Colorectal and Ovary (PLCO) cancer trial in the USA and the European Randomized Screening for Prostate Cancer (ERSPC) trial in Europe are currently under way, aimed at assessing whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c94377d4fe81a8ed75306a3102b6a290
https://doi.org/10.1002/ijc.1588

Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study

Autor: Dijkstra, Akkelies E., Smolonska, J, Van Den Berge, M, Wijmenga, C, Zanen, P, Luinge, MA, Platteel, M, Lammers, JW, Dahlback, M, Tosh, K, Hiemstra, PS, Sterk, PJ, Spira, A, Vestbo, J, Nordestgaard, BG, Benn, M, Nielsen, SF, Dahl, M, Verschuren, WM, Picavet, HSJ, Smit, HA, Owsijewitsch, M, Kauczor, HU, De Koning, HJ, Nizankowska-Mogilnicka, E, Mejza, F, Nastalek, P, Van Diemen, CC, Cho, MH, Silverman, EK, Crapo, JD, Beaty, TH, Lomas, DA, Bakke, Per, Gulsvik, Amund, Bosse, Y, Obeidat, MA, Loth, DW, Lahousse, L, Rivadeneira, F, Uitterlinden, AG, Hofman, A, Stricker, BH, Brusselle, GG, Van Duijn, CM, Brouwer, U, Koppelman, GH, Vonk, JM, Nawijn, MC, Groen, HJM, Timens, W, Boezen, HM, Postma, DS, Alizadeh, BZ, De Boer, RA, Bruinenberg, M, Franke, L, Van Der Harst, P, Hillege, HL, Van Der Klauw, MM, Navis, G, Ormel, J, Rosmalen, J, Slaets, JP, Snieder, H, Stolk, RP, Wolffenbuttel, B

Publikováno v: PLoS ONE
Dijkstra, A E, Smolonska, J, van den Berge, M, Wijmenga, C, Zanen, P, Luinge, M A, Platteel, M, Lammers, J W, Dahlback, M, Tosh, K, Hiemstra, P S, Sterk, P J, Spira, A, Vestbo, J, Nordestgaard, B G, Benn, M, Nielsen, S F, Dahl, M, Verschuren, W M, Picavet, H S J, Smit, H A, Owsijewitsch, M, Kauczor, H U, de Koning, H J, Nizankowska-Mogilnicka, E, Mejza, F, Nastalek, P, van Diemen, C C, Cho, M H, Silverman, E K, Crapo, J D, Beaty, T H, Lomas, D A, Bakke, P, Gulsvik, A, Bosse, Y, Obeidat, M A, Loth, D W, Lahousse, L, Rivadeneira, F, Uitterlinden, A G, Hofman, A, Stricker, B H, Brusselle, G G, van Duijn, C, Brouwer, U, Koppelman, G H, Vonk, J M, Nawijn, M C, Groen, H J M, Timens, W, Boezen, H M, Postma, D S & LifeLines Cohort, S 2014, ' Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study ', P L o S One, vol. 9, no. 4, e91621, pp. 13 . https://doi.org/10.1371/journal.pone.0091621
LifeLines Cohort Study 2014, ' Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study ', PLoS ONE, vol. 9, no. 4, e91621 . https://doi.org/10.1371/journal.pone.0091621
e91621
PLoS ONE, 9(4). Public Library of Science
PLoS One (print), 9(4). Public Library of Science
PLoS ONE, Vol 9, Iss 4, p e91621 (2014)
PLoS ONE, 9(4)
PLOS ONE
PLoS ONE, 9(4):e91621. PUBLIC LIBRARY SCIENCE
PLoS ONE; Vol 9

Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74529ee25996a8245709890a3470ca4
https://pubmed.ncbi.nlm.nih.gov/26024482

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