Zobrazeno 1 - 10
of 18
pro vyhledávání: '"De Jin Zhan"'
Autor:
Hong You, Jawahar L. Mehta, C. Krishna Prasad, Maurizio Chiriva-Internati, Craig Meyers, Yong Liu, Paul L. Hermonat, De Jin Zhan
Publikováno v:
Virology. 314(1):423-431
Multiple epidemiologic studies show that adeno-associated virus (AAV) is negatively associated with cervical cancer (CX CA), a cancer which is positively associated with human papillomavirus (HPV) infection. Mechanisms for this correlation may be by
Publikováno v:
Polycyclic Aromatic Compounds. 22:853-859
Dibenz[ a,h ]anthracene (DB[ a,h ]A) and 7-nitrodibenz[ a,h ]anthracene (7-NDB[ a,h ]A) induced liver tumors when administered to neonatal B6C3F 1 mice. For protooncogene analysis, RNA was isolated from each of the liver tumors from treated mice and
Autor:
Paul L. Hermonat, Chunling Li, Groesbeck P. Parham, Alessandro D. Santin, Craig Meyers, De Jin Zhan, Yong Liu
Publikováno v:
Journal of Biological Chemistry. 274:31619-31624
Human papillomavirus type 16 (HPV-16) infection is positively associated with cervical cancer, whereas adeno-associated virus (AAV) infection is negatively associated with this same cancer. In earlier studies these two virus types have been shown to
Publikováno v:
Environmental and Molecular Mutagenesis. 31:60-69
1-, 3-, and 6-nitrobenzo[a]pyrene (nitro-BaP) are environmental contaminants that can be metabolized to genotoxic derivatives by either nitroreduction or ring-oxidation. In this study, we examined the types of mutations produced by the primary nitror
Autor:
Feng Yun Qui, Diogenes Herreno-Saenz, Linda S. Von Tungeln, Ping Yi, Joellen Lewtas, Peter P. Fu, De-Jin Zhan
Publikováno v:
Polycyclic Aromatic Compounds. 10:187-194
We have characterized the DNA adducts of a series of nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) formed under anaerobic conditions in vitro. Although the DNA adducts of nitro-PAHs formed through enzymatic nitroreduction are generally the C8-d
Publikováno v:
Cancer Letters. 101:37-42
The tumorigenicity of 7-chlorobenz[α]anthracene (7-C1-BA), an environmental contaminant, and 7-bromobenz[α]anthracene (7-Br-BA) was determined in the male B6C3F 1 newborn mouse. Mice receiving 7-C1-BA and 7-Br-BA by i.p. injections at a dose of 160
Publikováno v:
Environmental and Molecular Mutagenesis. 27:19-29
Both 1- and 3-nitrobenzo[a]pyrene (nitro-8aP) are environmental contaminants, potent mutagens in Salmonella, and moderate mutagens in Chinese hamster ovary (CHO) cells. The mutagenicity of their oxidized metabolites, trans-7,8-dihydroxy-anti-9,10-epo
Autor:
Linda S. Von Tungeln, Joellen Lewtas, De-Jin Zhan, Peter P. Fu, Yu-Sun Wu, Diogenes Herreno-Saenz, Li-Hsueh Chiu
Publikováno v:
Journal of Chromatography A. 710:149-157
32 P-Postlabeling-HPLC is a highly sensitive analytical method for identification of chemical-modified DNA adducts isolated from samples obtained from experimental animals or humans exposed to carcinogenic chemicals. To determine optimal 32 P-postlab
Publikováno v:
Polycyclic Aromatic Compounds. 7:19-26
Effect of caloric restriction (CR) on metabolism of 7-fluorobenz-[a]anthracene (7-F-BA), 7-chlorobenz[a]anthracene (7-Cl-BA), 7-bromo-benz[a]anthracene (7-Br-BA), and 7-nitrobenz[a]anthracene (7-nitro-BA) by mouse liver microsomes was studied. The re
Autor:
Qingsu Xia, Robert H. Heflich, Ping Yi, Ronald W. Hart, Peter P. Fu, Linda S. Von Tungeln, De-Jin Zhan
Publikováno v:
Cancer letters. 123(1)
We previously examined the tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA) and 7-bromobenz[a]anthracene (7-Br-BA) in the neonatal mouse bioassay and found that 7-Cl-BA and 7-Br-BA induced hepatocellular adenoma in 92 and 96% of the mice and hep