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The Simmet Lecture: New Horizons on an Old Landscape - Oxidative Stress, DNA Damage and Apoptosis in the Male Germ Line.

Autor: Aitken, RJ, De Iuliis, GN, Gibb, Z, Baker, MA

Publikováno v: Reproduction in Domestic Animals; Aug2012 Supplement, Vol. 47, p7-14, 8p, 1 Diagram

Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice.

Autor: Trigg N; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.; Department of Genetics Epigenetics Institute, Institute of Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Department of Pediatrics Epigenetics Institute, Institute of Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Center for Reproductive and Women's Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Schjenken JE; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Martin JH; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Skerrett-Byrne DA; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research, Deutsche Zentrum für Diabetesforschung, Neuherberg 85764, Germany., Smyth SP; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.; School of BioSciences Bio21 Molecular Sciences and Biotechnology Institute, Faculty of Science, University of Melbourne, Parkville, VIC 3010, Australia., Bernstein IR; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Anderson AL; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Stanger SJ; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Simpson ENA; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Tomar A; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research, Deutsche Zentrum für Diabetesforschung, Neuherberg 85764, Germany., Teperino R; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research, Deutsche Zentrum für Diabetesforschung, Neuherberg 85764, Germany., Conine CC; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Department of Pediatrics Epigenetics Institute, Institute of Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Center for Reproductive and Women's Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104., De Iuliis GN; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Roman SD; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.; NSW Health Pathology, Newcastle, NSW 2300, Australia., Bromfield EG; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.; School of BioSciences Bio21 Molecular Sciences and Biotechnology Institute, Faculty of Science, University of Melbourne, Parkville, VIC 3010, Australia., Dun MD; Cancer Signaling Research Group, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., Eamens AL; School of Health, University of the Sunshine Coast, Maroochydore, QLD 4558, Australia., Nixon B; School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 19; Vol. 121 (47), pp. e2409790121. Date of Electronic Publication: 2024 Nov 11.

Development of a model for studying the developmental consequences of oxidative sperm DNA damage by targeting redox-cycling naphthoquinones to the Sertoli cell population.

Autor: Fraser BA; Priority Research Centre for Reproductive Science, The University of Newcastle, Callaghan, NSW, 2308, Australia; Pregnancy and Reproduction Program, Hunter Medical Research Institute, Kookaburra Cct, New Lambton Heights, NSW, 2305, Australia; College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia. Electronic address: barbara.fraser@newcastle.edu.au., Wilkins AL; Priority Research Centre for Reproductive Science, The University of Newcastle, Callaghan, NSW, 2308, Australia; Pregnancy and Reproduction Program, Hunter Medical Research Institute, Kookaburra Cct, New Lambton Heights, NSW, 2305, Australia; College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia., De Iuliis GN; Priority Research Centre for Reproductive Science, The University of Newcastle, Callaghan, NSW, 2308, Australia; Pregnancy and Reproduction Program, Hunter Medical Research Institute, Kookaburra Cct, New Lambton Heights, NSW, 2305, Australia; College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia., Rebourcet D; Priority Research Centre for Reproductive Science, The University of Newcastle, Callaghan, NSW, 2308, Australia; Pregnancy and Reproduction Program, Hunter Medical Research Institute, Kookaburra Cct, New Lambton Heights, NSW, 2305, Australia; College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia., Nixon B; Priority Research Centre for Reproductive Science, The University of Newcastle, Callaghan, NSW, 2308, Australia; Pregnancy and Reproduction Program, Hunter Medical Research Institute, Kookaburra Cct, New Lambton Heights, NSW, 2305, Australia; College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia., Aitken RJ; Priority Research Centre for Reproductive Science, The University of Newcastle, Callaghan, NSW, 2308, Australia; Pregnancy and Reproduction Program, Hunter Medical Research Institute, Kookaburra Cct, New Lambton Heights, NSW, 2305, Australia; College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2023 Sep; Vol. 206, pp. 50-62. Date of Electronic Publication: 2023 Jun 23.

Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage.

Autor: Steffens Reinhardt L; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Zhang X; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Groen K; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Morten BC; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., De Iuliis GN; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, The University of Newcastle, Callaghan, NSW, Australia., Braithwaite AW; Children's Medical Research Institute, The University of Sydney, Sydney, NSW, Australia.; Department of Pathology, School of Medicine, The University of Otago, Dunedin, New Zealand., Bourdon JC; Dundee Cancer Centre, Ninewells Hospital and Medical School, The University of Dundee, Dundee, UK., Avery-Kiejda KA; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. Kelly.kiejda@newcastle.edu.au.; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. Kelly.kiejda@newcastle.edu.au.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Oct 28; Vol. 13 (10), pp. 907. Date of Electronic Publication: 2022 Oct 28.