Zobrazeno 1 - 10
of 802
pro vyhledávání: '"De Huang"'
Autor:
Lianmei Tan, Tao Yin, Handan Xiang, Liuyang Wang, Poorva Mudgal, Junying Chen, Yi Ding, Guoping Wang, Bryan Jian Wei Lim, Yuqi Huang, De Huang, Yaosi Liang, Peter B. Alexander, Kun Xiang, Ergang Wang, Chengsong Yan, Zhehao Ma, Minjia Tan, Qi-Jing Li, Xiao-Fan Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Immunotherapy successfully complements traditional cancer treatment. However, primary and acquired resistance might limit efficacy. Reduced antigen presentation by MHC-I has been identified as potential resistance factor. Here we show that t
Externí odkaz:
https://doaj.org/article/c5d42c601a2d43d98563c3b7367d8b29
Publikováno v:
Journal of the National Cancer Center, Vol 3, Iss 4, Pp 273-278 (2023)
Cellular senescence is characterized by a generally irreversible cell cycle arrest and the secretion of bioactive factors known as the senescence-associated secretory phenotype (SASP). In an oncogenic context, senescence is considered a tumor suppres
Externí odkaz:
https://doaj.org/article/2f69ba366d204514b5d2e852a4e0053b
Autor:
Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang
Publikováno v:
Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)
Abstract The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs’ full effects on mammalian ph
Externí odkaz:
https://doaj.org/article/31eefbea3ab7422289b0a16e728f1a35
Publikováno v:
Applied Surface Science Advances, Vol 6, Iss , Pp 100176- (2021)
When a seal is applied to prevent leakage of a pressurized fluid it must be designed to sustain the hydrostatic load it is subjected to. One important aspect that the design must take into consideration is the possibility that the hydrostatic fluid l
Externí odkaz:
https://doaj.org/article/2d5cb2cde4484323804d85f22ac92cad
Publikováno v:
Crystals, Vol 12, Iss 9, p 1323 (2022)
To further elucidate the relationship between the growth stress and cracking of KDP (KH2PO4, potassium dihydrogen phosphate) crystals of different sizes, a three-dimensional finite element calculation was conducted to analyze the growth stress of KDP
Externí odkaz:
https://doaj.org/article/5502d3228e02413faf93ffd6727bbc7a
Autor:
Yi Ding, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H. Lin, Gehao Liang, Lifeng Yuan, Handan Xiang, Junying Chen, Tao Yin, Peter B. Alexander, Qian-Fei Wang, Er-Wei Song, Qi-Jing Li, Kris C. Wood, Xiao-Fan Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Resistance to anti-HER2 therapy in breast cancer remains a major obstacle in the clinic. Here the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target that is synthetically lethal with HER2 inhibition in br
Externí odkaz:
https://doaj.org/article/3b4653d4e9534695875c3adfe802cb21
Autor:
Xiaoyu Ma, Lin Wang, De Huang, Yunyan Li, Dongdong Yang, Tingting Li, Fudong Li, Linchong Sun, Haoran Wei, Kun He, Fazhi Yu, Debiao Zhao, Lan Hu, Songge Xing, Zhaoji Liu, Kui Li, Jing Guo, Zhenye Yang, Xin Pan, Ailing Li, Yunyu Shi, Junfeng Wang, Ping Gao, Huafeng Zhang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critica
Externí odkaz:
https://doaj.org/article/f6e7092fba7f4ee08377d36b15323b24
Autor:
Gongwei Wu, Mengqiu Yuan, Shengqi Shen, Xiaoyu Ma, Jingwen Fang, Lianbang Zhu, Linchong Sun, Zhaoji Liu, Xiaoping He, De Huang, Tingting Li, Chenchen Li, Jun Wu, Xin Hu, Zhaoyong Li, Libing Song, Kun Qu, Huafeng Zhang, Ping Gao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Menin is a protein with context-dependent oncogenic or oncosuppressive roles; the oncogenic activity is mainly due to its function as a cofactor of the MLL1 histone methyltransferase complex. Here the authors show that Menin regulates c-Myc-dependent
Externí odkaz:
https://doaj.org/article/eb251e3ef25c49b493a9316cb673b601
Publikováno v:
Lubricants, Vol 9, Iss 1, p 1 (2020)
A finite element model of a static seal assembled in its housing has been built and is utilized to study how the seal deforms under varying loading conditions. The total contact load on the sealing surface is balanced by the sealed fluid pressure and
Externí odkaz:
https://doaj.org/article/7c1829627c514c4f92826f25578f6239
Autor:
De Huang, Tingting Li, Xinghua Li, Long Zhang, Linchong Sun, Xiaoping He, Xiuying Zhong, Dongya Jia, Libing Song, Gregg L. Semenza, Ping Gao, Huafeng Zhang
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1930-1942 (2014)
Hypoxia-inducible factor 1 (HIF-1) mediates a metabolic switch that blocks the conversion of pyruvate to acetyl-CoA in cancer cells. Here, we report that HIF-1α also inhibits fatty acid β-oxidation (FAO), another major source of acetyl-CoA. We iden
Externí odkaz:
https://doaj.org/article/fda5f31cc6aa4f27ae184a2a2f6c261c