Zobrazeno 1 - 10 of 122 pro vyhledávání: '"De Hoyos CL"'
1
Akademický článek
The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.
Autor: Zhang L; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Liang XH; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., De Hoyos CL; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Migawa M; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Nichols JG; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Freestone G; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Tian J; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Seth PP; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Crooke ST; Department of Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Publikováno v: Nucleic acid therapeutics [Nucleic Acid Ther] 2022 Oct; Vol. 32 (5), pp. 401-411. Date of Electronic Publication: 2022 Jul 20.
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2
Akademický článek
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Autor: Anderson BA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Freestone GC; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Low A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., De-Hoyos CL; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Iii WJD; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Østergaard ME; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Migawa MT; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Fazio M; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Wan WB; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Berdeja A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Scandalis E; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Burel SA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Vickers TA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Swayze EE; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Liang X; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Seth PP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9026-9041.
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3
Akademický článek
Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
Autor: Liang XH; Core Antisense Research, Carlsbad, CA 92010, USA., Nichols JG; Core Antisense Research, Carlsbad, CA 92010, USA., De Hoyos CL; Core Antisense Research, Carlsbad, CA 92010, USA., Sun H; Antisense Drug Discovery, Ionis Pharmaceuticals, Inc., Carlsbad, CA 92010, USA., Zhang L; Core Antisense Research, Carlsbad, CA 92010, USA., Crooke ST; Core Antisense Research, Carlsbad, CA 92010, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Aug 20; Vol. 49 (14), pp. 8277-8293.
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4
Akademický článek
Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.
Autor: Prakash TP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Yu J; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Shen W; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., De Hoyos CL; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Berdeja A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Gaus H; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Liang XH; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Crooke ST; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Seth PP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Apr 05; Vol. 12 (6), pp. 922-927. Date of Electronic Publication: 2021 Apr 05 (Print Publication: 2021).
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5
Akademický článek
Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective.
Autor: Liang XH; Core Antisense Research and Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., De Hoyos CL; Core Antisense Research and Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Shen W; Core Antisense Research and Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Zhang L; Core Antisense Research and Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Fazio M; Medicinal Chemistry, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Crooke ST; Core Antisense Research and Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Publikováno v: Nucleic acid therapeutics [Nucleic Acid Ther] 2021 Apr; Vol. 31 (2), pp. 126-144. Date of Electronic Publication: 2021 Feb 02.
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6
Akademický článek
NAT10 resolves harmful nucleolar R-loops depending on its helicase domain and acetylation of DDX21.
Autor: Su, Kunqi1 (AUTHOR), Zhao, Zhuochen1 (AUTHOR), Wang, Yuying1 (AUTHOR), Sun, Shiqi1 (AUTHOR), Liu, Xiaofeng2 (AUTHOR), Zhang, Chunfeng3 (AUTHOR), Jiang, Yang1 (AUTHOR) 1410305107@bjmu.edu.cn, Du, Xiaojuan1 (AUTHOR) duxiaojuan100@bjmu.edu.cn
Publikováno v: Cell Communication & Signaling. 10/11/2024, Vol. 22 Issue 1, p1-20. 20p.
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7
Akademický článek
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Autor: Vasquez G; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Freestone GC; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Wan WB; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Low A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., De Hoyos CL; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Yu J; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Prakash TP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Ǿstergaard ME; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Liang XH; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Migawa MT; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Seth PP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 1828-1839.
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8
Akademický článek
Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity.
Autor: Liang XH; Core Antisense Research, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Nichols JG; Core Antisense Research, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., De Hoyos CL; Core Antisense Research, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Core Antisense Research, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9840-9858.
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9
Akademický článek
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Autor: Østergaard ME; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., De Hoyos CL; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Wan WB; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Shen W; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Low A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Berdeja A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Vasquez G; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Murray S; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Migawa MT; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Liang XH; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Seth PP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Feb 28; Vol. 48 (4), pp. 1691-1700.
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10
Akademický článek
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Autor: Liang XH; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA., Sun H; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA., Hsu CW; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA., Nichols JG; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA., Vickers TA; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA., De Hoyos CL; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA., Crooke ST; Core Antisense Research, Ionis Pharmaceuticals, Inc. Carlsbad, CA 92104, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Feb 20; Vol. 48 (3), pp. 1372-1391.
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