Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Autor: Willems, SM, Wright, DJ, Day, FR, Trajanoska, K, Joshi, PK, Morris, JA, Matteini, AM, Garton, FC, Grarup, N, Oskolkov, N, Thalamuthu, A, Mangino, M, Liu, J, Demirkan, A, Lek, M, Xu, L, Wang, G, Oldmeadow, C, Gaulton, KJ, Lotta, LA, Miyamoto-Mikami, E, Rivas, MA, White, T, Loh, P-R, Aadahl, M, Amin, N, Attia, JR, Austin, K, Benyamin, B, Brage, S, Cheng, Y-C, Cięszczyk, P, Derave, W, Eriksson, K-F, Eynon, N, Linneberg, A, Lucia, A, Massidda, M, Mitchell, BD, Miyachi, M, Murakami, H, Padmanabhan, S, Pandey, A, Papadimitriou, I, Rajpal, DK, Sale, C, Schnurr, TM, Sessa, F, Shrine, N, Tobin, MD, Varley, I, Wain, LV, Wray, NR, Lindgren, CM, MacArthur, DG, Waterworth, DM, McCarthy, MI, Pedersen, O, Khaw, K-T, Kiel, DP, Oei, L, Zheng, H-F, Forgetta, V, Leong, A, Ahmad, OS, Laurin, C, Mokry, LE, Ross, S, Elks, CE, Bowden, J, Warrington, NM, Murray, A, Ruth, KS, Tsilidis, KK, Medina-Gómez, C, Estrada, K, Bis, JC, Chasman, DI, Demissie, S, Enneman, AW, Hsu, Y-H, Ingvarsson, T, Kähönen, M, Kammerer, C, Lacroix, AZ, Li, G, Liu, C-T, Liu, Y, Lorentzon, M, Mägi, R, Mihailov, E, Milani, L, Moayyeri, A, Nielson, CM, Sham, PC, Siggeirsdotir, K, Sigurdsson, G, Stefansson, K, Trompet, S, Thorleifsson, G, Vandenput, L, van der Velde, N, Viikari, J, Xiao, S-M, Zhao, JH, Evans, DS, Cummings, SR, Cauley, J, Duncan, EL, de Groot, LCPGM, Esko, T, Gudnason, V, Harris, TB, Jackson, RD, Jukema, JW, Ikram, AMA, Karasik, D, Kaptoge, S, Kung, AWC, Lehtimäki, T, Lyytikäinen, L-P, Lips, P, Luben, R, Metspalu, A, van Meurs, JBJ, Minster, RL, Orwoll, E, Oei, E, Psaty, BM, Raitakari, OT, Ralston, SW, Ridker, PM, Robbins, JA, Smith, AV, Styrkarsdottir, U, Tranah, GJ, Thorstensdottir, U, Uitterlinden, AG, Zmuda, J, Zillikens, MC, Ntzani, EE, Evangelou, E, Ioannidis, JPA, Evans, DM, Ohlsson, C, Pitsiladis, Y, Fuku, N, Franks, PW, North, KN, van Duijn, CM, Mather, KA, Hansen, T, Hansson, O, Spector, T, Murabito, JM, Richards, JB, Rivadeneira, F, Langenberg, C, Perry, JRB, Wareham, NJ, Scott, RA

Publikováno v: Nature communications, vol 8, iss 1
Nature Communications, 8
Nature Communications
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
NATURE COMMUNICATIONS
Nature Communications 8 (2017)
Willems, S M, et al., Grarup, N, Linneberg, A, Schnurr, T M, Pedersen, O, GEFOS Any-Type of Fracture Consortium & Hansen, T 2017, ' Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness ', Nature Communications, vol. 8, 16015 . https://doi.org/10.1038/ncomms16015
Willems, S M, Wright, D J, Day, F R, Trajanoska, K, Joshi, P K, Morris, J A, Matteini, A M, Garton, F C, Grarup, N, Oskolkov, N, Thalamuthu, A, Mangino, M, Liu, J, Demirkan, A, Lek, M, Xu, L, Wang, G, Oldmeadow, C, Gaulton, K J, Lotta, L A, Miyamoto-Mikami, E, Rivas, M A, White, T, Loh, P R, Aadahl, M, Amin, N, Attia, J R, Austin, K, Benyamin, B, Brage, S, Cheng, Y C, Ciȩszczyk, P, Derave, W, Eriksson, K F, Eynon, N, Linneberg, A, Lucia, A, Massidda, M, Mitchell, B D, Miyachi, M, Murakami, H, Padmanabhan, S, Pandey, A, Papadimitriou, I, Rajpal, D K, Sale, C, Schnurr, T M, Sessa, F, Shrine, N, Hansen, T & GEFOS Anytype of Fracture Consortium 2017, ' Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness ', Nature Communications, vol. 8, 16015 . https://doi.org/10.1038/ncomms16015
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, 8:16015. Nature Publishing Group
Willems, S M, Wright, D J, Day, F R, Trajanoska, K, Joshi, P K, Morris, J A, Matteini, A M, Garton, F C, Grarup, N, Oskolkov, N, Thalamuthu, A, Mangino, M, Liu, J, Demirkan, A, Lek, M, Xu, L, Wang, G, Oldmeadow, C, Gaulton, K J, Lotta, L A, Miyamoto-Mikami, E, Rivas, M A, White, T, Loh, P R, Aadahl, M, Amin, N, Attia, J R, Austin, K, Benyamin, B, Brage, S, Cheng, Y C, Ciȩszczyk, P, Derave, W, Eriksson, K F, Eynon, N, Linneberg, A, Lucia, A, Massidda, M, Mitchell, B D, Miyachi, M, Murakami, H, Padmanabhan, S, Pandey, A, Papadimitriou, I, Rajpal, D K, Sale, C, Schnurr, T M, Sessa, F, Shrine, N, Tobin, M D, Varley, I, Wain, L V, Wray, N R, Lindgren, C M, MacArthur, D G, Waterworth, D M, McCarthy, M I, Pedersen, O, Khaw, K T, Kiel, D P, Pitsiladis, Y, Fuku, N, Franks, P W, North, K N, Van Duijn, C M, Mather, K A, Hansen, T, Hansson, O, Spector, T, Murabito, J M, Richards, J B, Rivadeneira, F, Langenberg, C, Perry, J R B, Wareham, N J, Scott, R A, Oei, L, Zheng, H F, Forgetta, V, Leong, A, Ahmad, O S, Laurin, C, Mokry, L E, Ross, S, Elks, C E, Bowden, J, Warrington, N M, Murray, A, Ruth, K S, Tsilidis, K K, Medina-Gómez, C, Estrada, K, Bis, J C, Chasman, D I, Demissie, S, Enneman, A W, Hsu, Y H, Ingvarsson, T, Kähönen, M, Kammerer, C, Lacroix, A Z, Li, G, Liu, C T, Liu, Y, Lorentzon, M, Mägi, R, Mihailov, E, Milani, L, Moayyeri, A, Nielson, C M, Sham, P C, Siggeirsdotir, K, Sigurdsson, G, Stefansson, K, Trompet, S, Thorleifsson, G, Vandenput, L, Van Der Velde, N, Viikari, J, Xiao, S M, Zhao, J H, Evans, D S, Cummings, S R, Cauley, J, Duncan, E L, De Groot, L C P G M, Esko, T, Gudnason, V, Harris, T B, Jackson, R D, Jukema, J W, Ikram, A M A, Karasik, D, Kaptoge, S, Kung, A W C, Lehtimäki, T, Lyytikäinen, L P, Lips, P, Luben, R, Metspalu, A, Van Meurs, J B J, Minster, R L, Orwoll, E, Oei, E, Psaty, B M, Raitakari, O T, Ralston, S W, Ridker, P M, Robbins, J A, Smith, A V, Styrkarsdottir, U, Tranah, G J, Thorstensdottir, U, Uitterlinden, A G, Zmuda, J, Zillikens, M C, Ntzani, E E, Evangelou, E, Ioannidis, J P A, Evans, D M & Ohlsson, C 2017, ' Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness ', Nature Communications, vol. 8, 16015 . https://doi.org/10.1038/ncomms16015
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcc1f9f3f763e8acce552d31dcbf930
https://hdl.handle.net/11541.2/130359

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

Autor: Wijngaarden, JP, Swart, KMA, Enneman, Anke, Dhonukshe-Rutten, RAM, Boon - van Dijk, Suzanne, Ham, Annelies, Brouwer-Brolsma, EM, van der Zwaluw, NL, Sohl, L, van Meurs, Joyce, Zillikens, M.C., Schoor, NM, van der Velde, Nathalie, Brug, J, Uitterlinden, André, Lips, P, de Groot, LCPGM (Lisette)

Publikováno v: American Journal of Clinical Nutrition, 100(6), 1578-1586. American Society for Nutrition

Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk. Objective: This study [B-vitamins for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5a7a96cb97c2d3b02414f4b6d81d9c8c
https://pure.eur.nl/en/publications/8aa8beb2-5dfa-482b-981e-8d436b74b06b

Serum 25-Hydroxyvitamin D is not Associated With Domain-Specific Cognitive Performance in Dutch Elderly

Autor: Brouwer-Brolsma, EM, Dhonukshe-Rutten, RAM, Wijngaarden, JP, van der Zwaluw, NL, in t Veld, P, Kessels, RPC, Sohl, E, Boon - van Dijk, Suzanne, Schoor, NM, van der Velde, Nathalie, Uitterlinden, André, Lips, P, Feskens, EJM, de Groot, LCPGM (Lisette)

Publikováno v: Journal of Psychophysiology, 27, 50-51. Hogrefe Publishing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b31dfe3361df8e4d88f6ea58f9483bfd
https://pure.eur.nl/en/publications/b113cbd3-97d0-4f2a-ad64-322a296ddf49

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