Zobrazeno 1 - 10
of 1 221
pro vyhledávání: '"De Groot, MJ"'
Autor:
Yoon JG; Department of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., Lim SK; Department of Pharmacology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea., Seo H; Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Lee S; Department of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea., Cho J; Department of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea., Kim SY; Department of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea., Koh HY; Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Poduri AH; Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Ramakumaran V; LNR Genomic Medicine Service, University Hospitals of Leicester NHS Trust, Leicester, UK., Vasudevan P; LNR Genomic Medicine Service, University Hospitals of Leicester NHS Trust, Leicester, UK., de Groot MJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., Ko JM; Department of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea., Han D; Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Medicine, Seoul National University College of Medicine, Seoul, Korea., Chae JH; Department of Genomic Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. Electronic address: chaeped1@snu.ac.kr., Lee CH; Department of Pharmacology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Wide River Institute of Immunology, Seoul National University, Hongcheon, Republic of Korea; The Institute of Molecular Biology & Genetics, Seoul National University, Seoul, Republic of Korea. Electronic address: chulhwan@snu.ac.kr.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2024 Aug 08; Vol. 111 (8), pp. 1588-1604. Date of Electronic Publication: 2024 Jul 23.
Autor:
Brodeur KE; Boston Children's Hospital, Boston, Massachusetts., Liu M; Boston Children's Hospital, Boston, Massachusetts, and Guangdong Second Provincial General Hospital, Guangzhou, China., Ibanez D; Boston Children's Hospital, Boston, Massachusetts., de Groot MJ; Boston Children's Hospital, Boston, Massachusetts, and Heidelberg University Hospital, Heidelberg, Germany., Chen L; Boston Children's Hospital, Boston, Massachusetts., Du Y; Boston Children's Hospital, Boston, Massachusetts, and The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Seyal E; Boston Children's Hospital, Boston, Massachusetts., Laza-Briviesca R; Boston Children's Hospital, Boston, Massachusetts., Baker A; Boston Children's Hospital, Boston, Massachusetts., Chang JC; Boston Children's Hospital, Boston, Massachusetts., Chang MH; Boston Children's Hospital, Boston, Massachusetts., Day-Lewis M; Boston Children's Hospital, Boston, Massachusetts., Dedeoglu F; Boston Children's Hospital, Boston, Massachusetts., Dionne A; Boston Children's Hospital, Boston, Massachusetts., de Ferranti SD; Boston Children's Hospital, Boston, Massachusetts., Friedman KG; Boston Children's Hospital, Boston, Massachusetts., Halyabar O; Boston Children's Hospital, Boston, Massachusetts., Lo MS; Boston Children's Hospital, Boston, Massachusetts., Meidan E; Boston Children's Hospital, Boston, Massachusetts., Sundel RP; Boston Children's Hospital, Boston, Massachusetts., Henderson LA; Boston Children's Hospital, Boston, Massachusetts., Nigrovic PA; Boston Children's Hospital and Brigham and Women's Hospital, Boston, Massachusetts., Newburger JW; Boston Children's Hospital, Boston, Massachusetts., Son MB; Boston Children's Hospital, Boston, Massachusetts., Lee PY; Boston Children's Hospital, Boston, Massachusetts.
Publikováno v:
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Feb; Vol. 76 (2), pp. 285-292. Date of Electronic Publication: 2023 Nov 20.
Autor:
Andrews MD; Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark., Dack KN; Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark., de Groot MJ; Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark., Lambert M; Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark., Sennbro CJ; Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark., Larsen M; Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark., Stahlhut M; Skin Research, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2022 Jul 14; Vol. 65 (13), pp. 8828-8842. Date of Electronic Publication: 2022 Jun 29.
Autor:
Schmitz EM; Department of Clinical Chemistry and Hematology, 8185Máxima MC, Veldhoven, The Netherlands., Langelaan ML; Department of Clinical Chemistry and Hematology, 89411Amphia Hospital, Breda, The Netherlands., de Groot MJ; Department of Clinical Chemistry and Hematology, 7898Elisabeth TweeSteden Hospital, Tilburg, The Netherlands., Ermens TA; Department of Clinical Chemistry and Hematology, 89411Amphia Hospital, Breda, The Netherlands., Joosen AM; Department of Clinical Chemistry and Hematology, 8185Máxima MC, Veldhoven, The Netherlands.
Publikováno v:
Annals of clinical biochemistry [Ann Clin Biochem] 2022 May; Vol. 59 (3), pp. 199-204. Date of Electronic Publication: 2022 Mar 02.
Autor:
Rüllke, Marcel1 (AUTHOR), Schönrock, Veronika1 (AUTHOR), Schmitz, Kevin1 (AUTHOR), Oreb, Mislav2 (AUTHOR), Tamayo, Elisabeth1 (AUTHOR), Benz, J. Philipp1 (AUTHOR) benz@hfm.tum.de
Publikováno v:
Microbial Cell Factories. 10/5/2024, Vol. 23 Issue 1, p1-14. 14p.
Publikováno v:
Journal of Medicinal Chemistry. 42:4062-4070
A combined protein and pharmacophore model for cytochrome P450 2D6 (CYP2D6) has been extended with a second pharmacophore in order to explain CYP2D6 catalyzed N-dealkylation reactions. A group of 14 experimentally verified N-dealkylation reactions fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcf95e58cbeeed6de38cf76091273e2
https://doi.org/10.1021/jm991058v
https://doi.org/10.1021/jm991058v
Publikováno v:
de Groot, M J, Bijlo, G J, Martens, B J, Goeptar, A R & Vermeulen, N P E 1997, ' A refined substrate model for human cytochrome P450 2D6. ', SON Discussiegroep Farmacochemie, Lunteren, 14/04/97-15/04/97 .
SON Discussiegroep Farmacochemie, Lunteren
Chemical Research in Toxicology, 10, 41-48. American Chemical Society
de Groot, M J, Bijlo, G J, Martens, B J, van Acker, F A A & Vermeulen, N P E 1997, ' A refined substrate model for human cytochrome P450 2D6. ', Chemical Research in Toxicology, vol. 10, pp. 41-48 . https://doi.org/10.1021/tx960129f
Vrije Universiteit Amsterdam
SON Discussiegroep Farmacochemie, Lunteren
Chemical Research in Toxicology, 10, 41-48. American Chemical Society
de Groot, M J, Bijlo, G J, Martens, B J, van Acker, F A A & Vermeulen, N P E 1997, ' A refined substrate model for human cytochrome P450 2D6. ', Chemical Research in Toxicology, vol. 10, pp. 41-48 . https://doi.org/10.1021/tx960129f
Vrije Universiteit Amsterdam
Cytochromes P450 (P450s) constitute a large superfamily of heme-containing enzymes, capable of oxidizing and reducing a variety of substrates. Cytochrome P450 2D6 is a polymorphic member of the P450 superfamily and is absent in 5-9% of the Caucasian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38bb2228cbaf8a81c5aab27afe7b49a
https://doi.org/10.1021/tx960129f
https://doi.org/10.1021/tx960129f
Publikováno v:
Chemical Research in Toxicology, 9, 1079-1091. American Chemical Society
de Groot, M J, Vermeulen, N P E, Kramers, J D, van Acker, F A A & Donné-Op den Kelder, G M 1996, ' A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108. ', Chemical Research in Toxicology, vol. 9, pp. 1079-1091 . https://doi.org/10.1021/tx960003i
de Groot, M J, Vermeulen, N P E, Kramers, J D, van Acker, F A A & Donné-Op den Kelder, G M 1996, ' A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108. ', Chemical Research in Toxicology, vol. 9, pp. 1079-1091 . https://doi.org/10.1021/tx960003i
Cytochromes P450 (P450s) constitute a superfamily of phase I enzymes capable of oxidizing and reducing various substrates. P450 2D6 is a polymorphic enzyme, which is absent in 5-9% of the Caucasian population as a result of a recessive inheritance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe669a2cfed74849198e09f97fb82d28
https://doi.org/10.1021/tx960003i
https://doi.org/10.1021/tx960003i
Autor:
Su, Yajie1,2 (AUTHOR), Wang, Yaqiong1 (AUTHOR), He, Jinfeng3 (AUTHOR), Wang, Huijun4 (AUTHOR), A, Xian2 (AUTHOR), Jiang, Haili2 (AUTHOR), Lu, Wei5 (AUTHOR), Zhou, Wenhao1,4,6 (AUTHOR) zhouwenhao@fudan.edu.cn, Li, Long2 (AUTHOR) lilong65@126.com
Publikováno v:
BMC Medicine. 9/11/2024, Vol. 22 Issue 1, p1-12. 12p.
Autor:
Rocha, Júlio C.1,2,3 (AUTHOR) rochajc@nms.unl.pt, Hermida, Álvaro4 (AUTHOR), Jones, Cheryl J.5 (AUTHOR), Wu, Yunchou5 (AUTHOR), Clague, Gillian E.6 (AUTHOR), Rose, Sarah6 (AUTHOR), Whitehall, Kaleigh B.6 (AUTHOR), Ahring, Kirsten K.7 (AUTHOR), Pessoa, André L. S.8,9 (AUTHOR), Harding, Cary O.10 (AUTHOR), Rohr, Fran11 (AUTHOR), Inwood, Anita12 (AUTHOR), Longo, Nicola13 (AUTHOR), Muntau, Ania C.14 (AUTHOR), Sivri, Serap15 (AUTHOR), Maillot, François16 (AUTHOR)
Publikováno v:
Orphanet Journal of Rare Diseases. 9/12/2024, Vol. 19 Issue 1, p1-22. 22p.