Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode

Autor: Hedir, Siham, De Giorgi, Marcella, Fogha, Jade, De Pascale, Martina, Weiswald, Louis-Bastien, Brotin, Emilie, Marekha, Bogdan, Denoyelle, Christophe, Denis, Camille, Suzanne, Peggy, Gautier, Fabien, Juin, Philippe, Ligat, Laetitia, Lopez, Frédéric, Carlier, Ludovic, Legay, Rémi, Bureau, Ronan, Rault, Sylvain, Poulain, Laurent, Oliveira Santos, Jana Sopková-de, Voisin-Chiret, Anne Sophie

Publikováno v: In European Journal of Medicinal Chemistry 5 November 2018 159:357-380

Design and synthesis of thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein–protein interactions disruptors

Autor: De Giorgi, Marcella, Voisin-Chiret, Anne Sophie, Sopková-de Oliveira Santos, Jana, Corbo, Filomena, Franchini, Carlo, Rault, Sylvain

Publikováno v: In Tetrahedron 2011 67(34):6145-6154

Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes

Autor: Chekkat, Neila, Lombardo, Caterina, Seguin, Cendrine, Lechner, Marie-Charlotte, Dufour, Florent, Nominé, Yves, De Giorgi, Marcella, Frisch, Benoît, Micheau, Olivier, Guichard, Gilles, Altschuh, Danièle, Fournel, Sylvie

Publikováno v: Oncotarget
Oncotarget, Impact journals, In press, 〈10.18632/oncotarget.24526〉
Oncotarget, Impact journals, 2018, 9 (21), pp.15566-15578
Oncotarget, 2018, 9 (21), pp.15566-15578. ⟨10.18632/oncotarget.24526⟩
Oncotarget, Impact journals, 2018, 9 (21), pp.15566-15578. ⟨10.18632/oncotarget.24526⟩

IF 5.168 (2016); International audience; Tumor Necrosis Factor Receptor Apoptosis Inducing Ligand (TRAIL) appears as an interesting candidate for targeted cancer therapy as it induces apoptosis in cancer cells without toxicity to normal cells. TRAIL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c475867eea0c9527712079a69de88e9d
http://www.hal.inserm.fr/inserm-01717537

Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes.

Autor: De Pascale, Martina, Iacopetta, Domenico, Since, Marc, Corvaisier, Sophie, Vie, Véronique, Paboeuf, Gilles, Hennequin, Didier, Perato, Serge, De Giorgi, Marcella, Sinicropi, Maria Stefania, Sopkova‐De Oliveira Santos, Jana, Voisin‐Chiret, Anne‐Sophie, Malzert‐Freon, Aurélie

Publikováno v: ChemMedChem; 1/7/2020, Vol. 15 Issue 1, p136-154, 19p

MCL-1 Modulating compounds for Cancer Treatment

Autor: Poulain, Laurent, Voisin-Chiret, Anne-Sophie, Sopkova de Oliveira Santos, Jana, Bureau, Ronan, Burzicki, Grégory, de Giorgi, Marcella, Perato, Serge, Fogha, Jade, Rault, Sylvain, Juin, Philippe, Gautier, Fabien

Publikováno v: France, Patent n° : WO 2015/132727. 2015
United States, Patent n° : US 20170071921 A1. 2019

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::23acd90d6e93c4e1f520e40220f06c82
https://www.hal.inserm.fr/inserm-02545373