Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial.

Autor: Viermyr HK; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway., Tonby K; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Infectious Diseases, Oslo University Hospital Ullevål, Oslo, Norway., Ponzi E; Department of Research Support for Clinical Trials, Oslo University Hospital, Oslo, Norway., Trouillet-Assant S; Centre International de Recherche en Infectiologie (CIRI), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, Lyon, France; Joint Research Unit Hospices Civils de Lyon-bioMerieux S.A., Hôpital Lyon Sud, Pierre-Bénite, France., Poissy J; Université Lille, Inserm U1285, CHU Lille, Pôle de Médecine Intensive-Réanimatin, CNRS, UMR 8576, France; Université Lille, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), F-59000, Lille, France., Arribas JR; Infectious Diseases Unit, Internal Medicine Department, La Paz University Hospital, IdiPAZ, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain., Dyon-Tafani V; Centre International de Recherche en Infectiologie (CIRI), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, Lyon, France., Bouscambert-Duchamp M; Hospices Civils de Lyon, Laboratoire de Virologie, Institut des Agents Infectieux de Lyon, Centre National de Référence des Virus Respiratoires France Sud, F-69317, Lyon, France; Université Claude Bernard Lyon 1, Virpath, CIRI, INSERM U1111, CNRS UMR5308, ENS Lyon, F-69372, Lyon, France., Assoumou L; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Paris, France., Halvorsen B; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Tekin NB; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Diallo A; ANRS, Maladies Infectieuses Emergentes, F-75015, Paris, France; Institut National de la Santé et de la Recherche Médicale, INSERM, F-75013, Paris, France., De Gastines L; ANRS, Maladies Infectieuses Emergentes, F-75015, Paris, France; Institut National de la Santé et de la Recherche Médicale, INSERM, F-75013, Paris, France., Munthe LA; Department of Immunology, Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Precision Immunotherapy Alliance, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Murphy SL; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ueland T; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway., Michelsen AE; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lund-Johansen F; Department of Immunology, Oslo University Hospital, Oslo, Norway; Precision Immunotherapy Alliance, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Mootien J; Intensive Care Unit, Antibiotic Stewardship Team, Groupe Hospitalier Région Mulhouse et Sud Alsace, Mulhouse, France., Dervieux B; Infectious Diseases Unit, Groupe Hospitalier Région Mulhouse et Sud Alsace, Mulhouse, France., Zerbib Y; Intensive Care Department, Amiens-Picardie University Hospital, Amiens, France., Richard JC; Medical Intensive Care Unit, Hospices Civils de Lyon, Croix-Rousse Hospital - Université Lyon 1, Lyon, France; CREATIS INSERM 1044 CNRS 5220, Villeurbanne, France., Prével R; CHU Bordeaux, Medical Intensive Care Unit, Bordeaux, France; Univ Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, Inserm UMR 1045, Bordeaux, France., Malvy D; Department of Infectious and Tropical Diseases, University Hospital, UMR 1219 Inserm/EMR 271 IRD, University of Bordeaux, Bordeaux, France., Timsit JF; AP-HP, Bichat Hospital, Medical and Infectious Diseases ICU (MI2), F-75018, Paris, France; Université Paris-Cité, INSERM, F-75018, Paris, France; OUCTOME REA Research Network, France., Peiffer-Smadja N; Université Paris Cité, Inserm, IAME, Paris, 75018, France; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat Claude Bernard, AP-HP, Paris, 75018, France., Roux D; Université Paris Cité, AP-HP, Hôpital Louis Mourier, DMU ESPRIT, Service de Médecine Intensive Réanimation, Colombes, France., Piroth L; Infectious Diseases Department, University Hospital, Dijon, France; INSERM CIC 1432, University of Burgundy, Dijon, France., Ait-Oufella H; Service de Médecine Intensive-Réanimation, Hôpital Saint-Antoine, AP-HP, Sorbonne Université, Paris, F-75012, France., Vieira C; Centro Hospitalar Universitário de Lisboa Central, Hospital Curry Cabral, Department of Intensive Care Medicine - Lisbon, Portugal., Dalgard O; Department of Infectious Diseases, Oslo University Hospital Ullevål, Oslo, Norway; Department of Infectious Diseases, Akershus University Hospital, Norway., Heggelund L; Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Norway; Department of Clinical Science, Bergen Integrated Diagnostic Stewardship Cluster, Faculty of Medicine, University of Bergen, Bergen, Norway., Müller KE; Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Norway; Department of Clinical Science, Bergen Integrated Diagnostic Stewardship Cluster, Faculty of Medicine, University of Bergen, Bergen, Norway., Møller JH; Department of Intensive Care Medicine, Stavanger University Hospital, Stavanger, Norway., Kildal AB; Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø, Norway; Faculty of Health Sciences, UIT The Arctic University of Norway, Norway., Skogen V; Department of Infectious Diseases, University Hospital of North Norway, Tromsø, Norway; Faculty of Health Sciences, UIT The Arctic University of Norway, Norway., Aballi S; Department of Infectious Diseases, Østfold Hospital Kalnes, Grålum, Norway., Sjøberg Øgaard JD; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Dyrhol-Riise AM; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Infectious Diseases, Oslo University Hospital Ullevål, Oslo, Norway., Tveita A; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; Department of Internal Medicine, Bærum Hospital, Vestre Viken Hospital Trust, 1346, Gjettum, Norway., Alirezaylavasani A; Department of Immunology, Oslo University Hospital, Oslo, Norway., Costagliola D; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Paris, France., Yazdanpanah Y; Infectious and Tropical Diseases Department, Bichat - Claude Bernard Hospital, AP-HP Nord-Université Paris Cité, Paris, France; IAME INSERM UMR 1137, Université Paris Cité, Paris, France; ANRS, Maladies Infectieuses Emergentes, F-75015, Paris, France; Institut National de la Santé et de la Recherche Médicale, INSERM, F-75013, Paris, France., Olsen IC; Department of Research Support for Clinical Trials, Oslo University Hospital, Oslo, Norway., Dahl TB; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Kared H; Department of Immunology, Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Precision Immunotherapy Alliance, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Holten AR; Department of Infectious Diseases, Oslo University Hospital Ullevål, Oslo, Norway; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway., Trøseid M; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address: marius.troseid@medisin.uio.no.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Dec 27; Vol. 111, pp. 105511. Date of Electronic Publication: 2024 Dec 27.

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Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial.

Autor: Trøseid M; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital, Oslo, Norway. marius.troseid@medisin.uio.no.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. marius.troseid@medisin.uio.no., Arribas JR; Infectious Diseases Unit, Internal Medicine Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain., Assoumou L; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie Et de Santé Publique (IPLESP), Paris, France., Holten AR; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway., Poissy J; Lille University, Lille, France/CHU Lille - Hôpital Roger Salengro, Lille, France.; L'Institut National de La Santé Et de La Recherche Médicale (Inserm), Paris, France., Terzić V; Maladies Infectieuses Emergentes, 75015, Paris, France.; Institut National de La Santé Et de La Recherche Médicale, INSERM, 75013, Paris, France., Mazzaferri F; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Baño JR; Department of Medicine, Virgen Macarena University Hospital, Seville, Spain.; University of Sevilla and Biomedicines Institute of Seville (IBiS)/CSIC, Seville, Spain.; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain., Eustace J; University College Cork, Cork, Ireland., Hites M; Brussels University Hospital-Erasme, Brussels, Belgium.; Université Libre de Bruxelles, Brussels, Belgium., Joannidis M; Medical University Innsbruck, Innsbruck, Austria., Paiva JA; Intensive Care Medicine Department, Centro Hospitalar Universitário Sao Joao, Porto, Portugal.; Faculty of Medicine, University of Porto, Porto, Portugal., Reuter J; Centre Hospitalier de Luxembourg, Service de Réanimation-Soins Intensifs, 1210, Luxembourg, Luxembourg., Püntmann I; Institute of Pharmacology, Hospital Group Gesundheit Nord gGmbH, Bremen, Germany., Patrick-Brown TDJH; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway., Westerheim E; Section for Monitoring, Clinical Trial Unit (CTU), Oslo University Hospital, Oslo, Norway., Nezvalova-Henriksen K; Department of Haematology, Oslo University Hospital and Oslo Hospital Pharmacy, Oslo, Norway., Beniguel L; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie Et de Santé Publique (IPLESP), Paris, France., Dahl TB; Research Institute for Internal Medicine, Oslo University Hospital, Oslo, Norway.; Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway., Bouscambert M; Laboratoire de Virologie, Institut Des Agents Infectieux de Lyon, Centre National de Reference Des Virus Des Infections Respiratoires France Sud, Hospices Civils de Lyon, 69317, Lyon, France., Halanova M; Department of Epidemiology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovakia., Péterfi Z; 1St Department of Internal Medicine, Division of Infectology, University of Pécs, Pécs, Hungary., Tsiodras S; National and Kapodistrian University of Athens, Athens, Greece.; University Hospital of Athens Attikon, Athens, Greece., Rezek M; St. Anne University Hospital, Brno, Czech Republic., Briel M; Swiss Clinical Trial Organisation and Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland., Ünal S; Hacettepe University Hospital, Ankara, Turkey., Schlegel M; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts Der Isar, Technische Universität München, Munich, Germany., Ader F; Hospices Civils de Lyon, Département Des Maladies Infectieuses Et Tropicales, 69004, Lyon, France.; Centre International de Recherche en Infectiologie (CIRI), Inserm 1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, 69007, Lyon, France., Lacombe K; Sorbonne Université, Institut Pierre-Louis d'Épidemiologie Et de Santé Publique, INSERM, 75013, Paris, France.; APHP, Hôpital Saint-Antoine, Service de Maladies Infectieuses Et Tropicales, 75012, Paris, France., Amdal CD; Research support service and Department of Oncology, Oslo University Hospital, Oslo, Norway., Rodrigues S; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie Et de Santé Publique (IPLESP), Paris, France., Tonby K; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Deptartment of Infectious Diseases, Oslo University Hospital, Oslo, Norway., Gaudet A; Critical Care Center, Department of Intensive Care Medicine, CHU Lille, 59000, Lille, France.; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d'Infection Et d'Immunité de Lille, 59000, Lille, France., Heggelund L; Medical Department, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Mootien J; Service, de Réanimation Médiale, GHRMSA Hopital Emile Muller, Mulhouse, France., Johannessen A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Infectious Diseases, Vestfold Hospital Trust, Tønsberg, Norway., Møller JH; Department of Intensive Care Medicine, Stavanger University Hospital, Stavanger, Norway., Pollan BD; Infectious Diseases Unit, Internal Medicine Department, La Paz University Hospital, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), IdiPAZ, Madrid, Spain., Tveita AA; Department of Medicine, Bærum Hospital, Vestre Viken, Bærum, Norway., Kildal AB; Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø, Norway., Richard JC; Service de Médecine Intensive-Réanimation, Hôpital de La Croix - Rousse - HCL, Lyon, France.; CREATIS INSERM U1206-CNRS UMR 5220, Lyon, France., Dalgard O; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Akershus University Hospital, Lørenskog, Norway., Simensen VC; Division of Health Services, Department of Global Health, Norwegian Institute of Public Health, Oslo, Norway., Baldé A; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie Et de Santé Publique (IPLESP), Paris, France., de Gastines L; Maladies Infectieuses Emergentes, 75015, Paris, France.; Institut National de La Santé Et de La Recherche Médicale, INSERM, 75013, Paris, France., Del Álamo M; ECRIN, Paris, France., Aydin B; Department of Immunology, Oslo University Hospital, Oslo, Norway., Lund-Johansen F; Department of Immunology, Oslo University Hospital, Oslo, Norway., Trabaud MA; Laboratoire de Virologie, Institut Des Agents Infectieux de Lyon, Centre National de Reference Des Virus Respiratoires France Sud, 69317, Hospices Civils de LyonLyon, France., Diallo A; Maladies Infectieuses Emergentes, 75015, Paris, France.; Institut National de La Santé Et de La Recherche Médicale, INSERM, 75013, Paris, France., Halvorsen B; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Røttingen JA; Norwegian Institute of Public Health, Oslo, Norway., Tacconelli E; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.; Verona University Hospital, Verona, Italy., Yazdanpanah Y; Université de Paris, IAME, INSERM, 75018, Paris, France.; AP-HP, Hôpital Bichat, Service de Maladies Infectieuses Et Tropicales, 75018, Paris, France., Olsen IC; Department of Research Support for Clinical Trials, Oslo University Hospital, Oslo, Norway., Costagliola D; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie Et de Santé Publique (IPLESP), Paris, France.

Publikováno v: Critical care (London, England) [Crit Care] 2023 Jan 10; Vol. 27 (1), pp. 9. Date of Electronic Publication: 2023 Jan 10.

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