Targeting tyrosine receptor kinase B in gliomas

Autor: Alves C, Kelly de Vargas Pinheiro, Massimo Squatrito, Roel G.W. Verhaak, de Farias Cb, Mirela Severo Gil, Gilberto Schwartsmann, Robert L. Bowman, Qianghu Wang, Marienela Buendia, Rafael Roesler, Carro A, Amanda Thomaz

Publikováno v: Neuro-oncology. 19(1)

Astrocytomas are the most common primary human brain tumors. Receptor tyrosine kinases (RTKs), including tyrosine receptor kinase B (TrkB, also known as tropomyosin-related kinase B; encoded by neurotrophic tyrosine kinase receptor type 2 [NTRK2]), a

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https://pubmed.ncbi.nlm.nih.gov/27402815

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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma.

Autor: Freire NH; Children's Cancer Institute (ICI), Porto Alegre, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Herlinger AL; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Vanini J; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Dalmolin M; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil.; InovAI Lab, nPITI/IMD, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Bioinformatics Multidisciplinary Environment (BioME), Federal University of Rio Grande do Norte, Natal, RN, Brazil., Fernandes MAC; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil.; InovAI Lab, nPITI/IMD, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Bioinformatics Multidisciplinary Environment (BioME), Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Department of Computer Engineering and Automation, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Nör C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., de Farias CB; Children's Cancer Institute (ICI), Porto Alegre, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Brunetto AT; Children's Cancer Institute (ICI), Porto Alegre, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Brunetto AL; Children's Cancer Institute (ICI), Porto Alegre, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Gregianin LJ; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil.; Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Pediatric Oncology Service, Clinical Hospital, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., da Cunha Jaeger M; Children's Cancer Institute (ICI), Porto Alegre, RS, Brazil.; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil., Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada.; Texas Children's Cancer and Hematology Center, Houston, TX, USA.; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.; Department of Neurosurgery, Texas Children's Hospital, Houston, TX, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Hematology-Oncology Section, Texas Children's Cancer Center, Houston, TX, USA., Roesler R; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre, RS, Brazil.; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.

A Case Study of a Rare Undifferentiated Spindle Cell Sarcoma of the Penis: Establishment and Characterization of Patient-Derived Models.

Autor: Sousa ACDS; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.; Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil., Fernandes BLNC; Sao Lucas Hospital Rede D'Or, Sergipe Emergency Hospital Oncology Service, Aracaju 49081-060, Brazil., da Silva JPA; Real Institute of Oncological Surgery, Real Hospital Português, Recife 52010-075, Brazil., Stevanato Filho PR; Reference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil., Coimbra LBCT; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil., de Oliveira Beserra A; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.; Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil., Alvarenga AL; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil., Maida G; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil., Guimaraes CT; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil., Nakamuta IM; Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, Brazil.; Heart Institute of School of Medicine, University of Sao Paulo, Sao Paulo 05403-900, Brazil., Marchi FA; Center for Translational Research in Oncology, Cancer Institute of the State of Sao Paulo (ICESP), Clinical Hospital of the University of Sao Paulo Medical School (HCFMUSP), Sao Paulo 01246-000, Brazil., Alves C; Ziel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil., Lichtenfels M; Ziel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil., de Farias CB; Ziel Biosciences, Department of Translational Research, Porto Alegre 90050-170, Brazil., Kupper BEC; Reference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil., Costa FD; Reference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil.; Anatomic Pathology Department, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil., de Mello CAL; Reference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil., Carraro DM; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil., Torrezan GT; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil., Lopes A; Reference Center in Sarcoma, A.C. Camargo Cancer Center, Sao Paulo 01509-900, Brazil., Dos Santos TG; Clinical and Functional Genomics Group, A.C. Camargo Cancer Center, Sao Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, Sao Paulo 01508-010, Brazil.

Publikováno v: Genes [Genes (Basel)] 2024 Mar 28; Vol. 15 (4). Date of Electronic Publication: 2024 Mar 28.

Targeting the epigenome of cancer stem cells in pediatric nervous system tumors.

Autor: Freire NH; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. natihogfreire@gmail.com.; Graduate Program in Cellular and Molecular Biology, Center of Biotechnology, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500 (Setor IV - Campus do Vale), Porto Alegre, 91501-970, Brazil. natihogfreire@gmail.com., Jaeger MDC; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Children's Cancer Institute, Porto Alegre, RS, Brazil., de Farias CB; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Children's Cancer Institute, Porto Alegre, RS, Brazil., Nör C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Souza BK; Epigenica Biosciences, Canoas, RS, Brazil., Gregianin L; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Pediatric Oncology Service, Clinical Hospital, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Brunetto AT; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Children's Cancer Institute, Porto Alegre, RS, Brazil., Roesler R; Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Graduate Program in Cellular and Molecular Biology, Center of Biotechnology, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500 (Setor IV - Campus do Vale), Porto Alegre, 91501-970, Brazil.; Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2023 Oct; Vol. 478 (10), pp. 2241-2255. Date of Electronic Publication: 2023 Jan 13.