Histone deacetylase inhibition mitigates fibrosis-driven disease progression in recessive dystrophic epidermolysis bullosa.

Autor: Primerano A; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., De Domenico E; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Cianfarani F; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., De Luca N; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Floriddia G; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Teson M; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Cristofoletti C; Laboratory of Molecular Oncology, IDI-IRCCS, Rome, Italy., Cardarelli S; Laboratory of Experimental Medicine, Department of Surgery, Sapienza University, Rome, Italy., Scaglione GL; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Baldini E; Laboratory of Experimental Medicine, Department of Surgery, Sapienza University, Rome, Italy., Cangelosi D; Clinical Bioinformatics, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Uva P; Clinical Bioinformatics, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Reinoso Sánchez JF; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Roubaty C; Department of Biology, University of Fribourg, Fribourg, Switzerland., Dengjel J; Department of Biology, University of Fribourg, Fribourg, Switzerland., Nyström A; Department of Dermatology, University of Freiburg, Freiburg, Germany., Mastroeni S; Clinical Epidemiology Unit, IDI-IRCCS, Rome, Italy., Ulisse S; Laboratory of Experimental Medicine, Department of Surgery, Sapienza University, Rome, Italy., Castiglia D; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy., Odorisio T; Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy.

Publikováno v: The British journal of dermatology [Br J Dermatol] 2024 Sep 18; Vol. 191 (4), pp. 568-579.

Chromatin accessibility profiling of targeted cell populations with laser capture microdissection coupled to ATAC-seq.

Autor: Carraro C; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. Electronic address: caterina.carraro@dzne.de., Bonaguro L; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany., Srinivasa R; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., van Uelft M; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Isakzai V; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Schulte-Schrepping J; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany., Gambhir P; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Elmzzahi T; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Immunogenomics & Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., Montgomery JV; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., Hayer H; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Li Y; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Immunogenomics & Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., Theis H; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany., Kraut M; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany., Mahbubani KT; Department of Surgery, University of Cambridge, and Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Aschenbrenner AC; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., König I; Core Research Facilities and Services, Light Microscope Facility (LMF), Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., Fava E; Core Research Facilities and Services, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., Fried HU; Core Research Facilities and Services, Light Microscope Facility (LMF), Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., De Domenico E; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany., Beyer M; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany; Immunogenomics & Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany., Saglam A; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany. Electronic address: a.saglam1980@gmail.com., Schultze JL; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany.

Publikováno v: Cell reports methods [Cell Rep Methods] 2023 Oct 23; Vol. 3 (10), pp. 100598. Date of Electronic Publication: 2023 Sep 29.

Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

Autor: Kapellos TS; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Baßler K; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Fujii W; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Nalkurthi C; Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia., Schaar AC; Institute of Computational Biology (ICB), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Mathematics, Technische Universität München, 85748 Garching, Germany., Bonaguro L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany., Pecht T; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Galvao I; Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia., Agrawal S; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Saglam A; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany., Dudkin E; Computational Life Sciences, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Frishberg A; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany; Institute of Computational Biology (ICB), Helmholtz Zentrum München, 85764 Neuherberg, Germany., de Domenico E; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany., Horne A; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Donovan C; University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia; Immune Health, Hunter Medical Research Institute, New Lambton and The University of Newcastle, Newcastle, NSW 2305, Australia., Kim RY; University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia; Immune Health, Hunter Medical Research Institute, New Lambton and The University of Newcastle, Newcastle, NSW 2305, Australia., Gallego-Ortega D; School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Garvan Institute of Medical Research, and St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia., Gillett TE; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AB Groningen, the Netherlands; GRIAC Research Institute, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Ansari M; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute of Computational Biology (ICB), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Schulte-Schrepping J; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Offermann N; Immunregulation, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany., Antignano I; Immunregulation, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany., Sivri B; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Lu W; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, 7250 TAS, Australia., Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, 7250 TAS, Australia., van Uelft M; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Osei-Sarpong C; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany., van den Berge M; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AB Groningen, the Netherlands; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands., Donker HC; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AB Groningen, the Netherlands; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands., Groen HJM; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AB Groningen, the Netherlands; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, 7250 TAS, Australia., Klein J; Department of Internal Medicine II, Pneumology, University Hospital Bonn, 53127 Bonn, Germany., Schreiber T; Department of Internal Medicine II, Pneumology, University Hospital Bonn, 53127 Bonn, Germany., Feißt A; University Clinics for Radiology, University Hospital Bonn, 53127 Bonn, Germany., Yildirim AÖ; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Schiller HB; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Nawijn MC; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AB Groningen, the Netherlands; GRIAC Research Institute, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., Becker M; Modular HPC and AI, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany., Händler K; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany; Institute of Human Genetics, University of Lübeck, 23562 Lübeck, Germany., Beyer M; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany., Capasso M; Immunregulation, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany., Ulas T; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany., Hasenauer J; Institute of Computational Biology (ICB), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Mathematics, Technische Universität München, 85748 Garching, Germany; Computational Life Sciences, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany., Pizarro C; Department of Internal Medicine II, Pneumology, University Hospital Bonn, 53127 Bonn, Germany., Theis FJ; Institute of Computational Biology (ICB), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Mathematics, Technische Universität München, 85748 Garching, Germany., Hansbro PM; Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia; University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia., Skowasch D; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, 7250 TAS, Australia., Schultze JL; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Mathematics, Technische Universität München, 85748 Garching, Germany. Electronic address: j.schultze@uni-bonn.de.

Publikováno v: Cell reports [Cell Rep] 2023 Jun 27; Vol. 42 (6), pp. 112525. Date of Electronic Publication: 2023 May 26.

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Autor: Aschenbrenner, A.C. Mouktaroudi, M. Krämer, B. Oestreich, M. Antonakos, N. Nuesch-Germano, M. Gkizeli, K. Bonaguro, L. Reusch, N. Baßler, K. Saridaki, M. Knoll, R. Pecht, T. Kapellos, T.S. Doulou, S. Kröger, C. Herbert, M. Holsten, L. Horne, A. Gemünd, I.D. Rovina, N. Agrawal, S. Dahm, K. van Uelft, M. Drews, A. Lenkeit, L. Bruse, N. Gerretsen, J. Gierlich, J. Becker, M. Händler, K. Kraut, M. Theis, H. Mengiste, S. De Domenico, E. Schulte-Schrepping, J. Seep, L. Raabe, J. Hoffmeister, C. ToVinh, M. Keitel, V. Rieke, G. Talevi, V. Skowasch, D. Aziz, N.A. Pickkers, P. van de Veerdonk, F.L. Netea, M.G. Schultze, J.L. Kox, M. Breteler, M.M.B. Nattermann, J. Koutsoukou, A. Giamarellos-Bourboulis, E.J. Ulas, T. German COVID-19 Omics Initiative (DeCOI)

BACKGROUND: The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::107b592271ccb709768f451d752d0897
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3076244

Heavy metal tolerance and polychlorinated biphenyl oxidation in bacterial communities inhabiting the Pasvik River and the Varanger Fjord area (Arctic Norway)

Autor: RAPPAZZO A.C., PAPALE M., RIZZO C., CONTE A., GIANNARELLI S., ONOR M., ABETE C., CEFALI P., DE DOMENICO E., MICHAUD L., LO GIUDICE A.

Publikováno v: Marine pollution bulletin. 141 (2019): 535–549.
info:cnr-pdr/source/autori:RAPPAZZO A.C., PAPALE M., RIZZO C., CONTE A., GIANNARELLI S., ONOR M., ABETE C., CEFALI P., DE DOMENICO E., MICHAUD L., LO GIUDICE A./titolo:Heavy metal tolerance and polychlorinated biphenyl oxidation in bacterial communities inhabiting the Pasvik River and the Varanger Fjord area (Arctic Norway)/doi:/rivista:Marine pollution bulletin./anno:2019/pagina_da:535/pagina_a:549/intervallo_pagine:535–549/volume:141

Heavy metals (HMs) and polychlorobiphenyls (PCBs) enter the Arctic environment through a variety of anthropogenic sources with deleterious effects towards biota and public health. Bacteria first transfer toxic compounds to higher trophic levels and,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::e9b5ff89620bf5edcf4e41c0bdf58990
http://www.cnr.it/prodotto/i/402027