Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva

Autor: Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Edward C. Hsiao, Richard Keen, Kim-Hanh Le Quan Sang, Donna R. Grogan, Rose Marino, Andrew R. Strahs, Frederick S. Kaplan

Publikováno v: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-13 (2023)

Abstract Background The design of clinical trials in rare diseases is often complicated by a lack of real-world translational knowledge. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by skeletal malformat

Externí odkaz: https://doaj.org/article/3d06cf9e3e804e1d98d678d462963546

CARACTERÍSTICAS SOCIODEMOGRÁFICAS DE MULHERES COM CÂNCER DE MAMA E FERIDAS EXOFÍTICAS

Autor: Bárbara Conte, Lucimere Maria dos Santos, Danilo Lima Ceccon, Gunnar Glauco de Cunto Carelli Taets

Publikováno v: Revista Enfermagem Atual in Derme, Vol 97, Iss 4 (2023)

Resumo: Câncer de mama é uma doença causada pela multiplicação desordenada de células anormais da mama. Diversas complicações podem ocorrer no decorrer da doença, como a ferida neoplásica. Essas feridas ocorrem pela infiltração das célul

Externí odkaz: https://doaj.org/article/083cf2ddfa0e484bb6bda2d853337966

Comparison of diagnoses of early-onset sepsis associated with use of Sepsis Risk Calculator versus NICE CG149: a prospective, population-wide cohort study in London, UK, 2020–2021

Autor: Kirsty Le Doare, Justin Richards, Paul T Heath, Justinas Teiserskas, Natasha Liow, Helen Smith, Ramnik Mathur, Ruth Shephard, Richard Nicholl, Nandiran Ratnavel, Elizabeth Eyre, Caroline Sullivan, Rie Yoshida, Maria Mendoza, Ambalika Das, Catherine Longley, Andrew Chapman, Shu-Ling Chuang, Sarah May Johnson, Christina Kortsalioudaki, Cheryl Battersby, Amit Verma, Catherine Douch, Keya Sahay, Neha Sharma, Igor Fierens, Tristan Bate, Yinru Lim, Chris Harris, Kate Ryan, Cheentan Singh, Hannah Walker, Alicia Demirjian, Theresa Lamagni, Mariam Elbakry, Neaha Patel, Giles Kendall, Ozioma Obi, Eleanor Hulse, Chloe Ann Cheang, Matthew Rubens, Katie Evans, Kazim Ghafoor, George Lawson, John Ho, Nichola Monks, Lidia Tyszczuk, Chinthika Piyasena, Anne Opute, Zainab Kassim, Sara Tho-Calvi, Erica Twum-Barimah, Divyen Shah, Sara Abdulla, Stephanie Tolan, Sophia Teoh, Siddhartha Paliwal, Uma Srirambhatla, Lucy Crossman, Rebecca Gaunt, Devangi Thakkar, Saranya Ravindran, Sara Farhat Dominguez, Sunanda Bhatia, Joana Freitas, Clare Cane, Ramyia Elangovan, Cassandra Gyamtso, Helen Nightingale, Angela De Cunto, Eleanor Duckworth, Clare Middleton, Lauren Ferretti, Catherine Warrick, Harshini Naidu, Daniel Geer, Nilmi Ekanayake, Lukas Huhn, Rita Marciano, Shivani Shah, Sonia Spathis, Jonathan Filkin, Mohammad Alam, Khadija Ben-Sasi, Julia Croft, Suzanne Sweeney, Reshmi Raychaudhuri, Evangelia Myttaraki, Ayesha Rahim, Sorana Galu, Joanna O'Sullivan, Jenni Jagodzinski, Remon Agaibi, Elmunzir Ahmed, Luvena Anthony, Luana Ayres da Silva, Nauman Balghari, Archana Bansal, Alexandra Briscoe, Sabina Checketts, Jagadish Chintapalli, Li Yan Chow, Jonathan Cookson, Daniel Crane, Andrew DeSilva, Stacey De Atougia, Mariana Gaspar Fonseca, Adeoya Gbemiga Olabamiji, Nicola Glogowski, Andrea Gronska, Jennifer Ho, Nichola Hodges, Ola Joseph, Keisha Kamalanathan, Jessica Kimpton, Niamh Langasco, Rosalie Lear, Amanda Moules, Rajvi Nagrecha, Noor Nusair, Chisaraokwu Nwachukwu, Felicity Ockelford, Chineze Okorowo, Yujing Ooi, Evgenia Panagiotopoulou, Nadia Saleem, Miriam Sanderson, Mashal Shamsuddin, Ana Silva Ferreira, Srikanthy Sivakanthan, Devika Thakur, Naomi Tobi, Madduka Umeh, Benjamin Ummat, Rebecca Unwin, Aarti Verma, Rebecca Wesson, Adelene Wong, Zijian (Chris) Zhang, Juliet Banya, Eleanor Bond, Rina Chotai, Hayley Clements, Alka Desai, Simon Drysdale, Lydia Eze, Laura Govender, Sophie Griffiths, Michela Groppo, Gopinathannair Harikumar, Linda Machakaire, Joselyn Morris, Amisha Singh, Maria Symeonaki, Mercy Ughwujabo, Kirsty Watts, Louis Yee, Jenny Ziprin

Publikováno v: BMJ Open, Vol 13, Iss 7 (2023)

Objective We sought to compare the incidence of early-onset sepsis (EOS) in infants ≥34 weeks’ gestation identified >24 hours after birth, in hospitals using the Kaiser Permanente Sepsis Risk Calculator (SRC) with hospitals using the National Ins

Externí odkaz: https://doaj.org/article/b6ba2bdb655044a89ee78a62402f1ff5

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