Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps.

Autor: Teijeira A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Garasa S; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Ochoa MC; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Sanchez-Gregorio S; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Gomis G; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Luri-Rey C; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Martinez-Monge R; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Department of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain., Pinci B; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Valencia K; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Solid Tumors Program, Center for Applied Medical Research (CIMA), Pamplona, Spain., Palencia B; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Barbés B; Department of Radiation Physics and Radiation Protection, Clínica Universidad de Navarra, Pamplona, Spain., Bolaños E; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Azpilikueta A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., García-Cardosa M; Department of Physics and Applied Mathematics, Universidad de Navarra, Pamplona, Spain., Burguete J; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Department of Physics and Applied Mathematics, Universidad de Navarra, Pamplona, Spain., Eguren-Santamaría I; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Department of Medical Oncology, Universidad de Navarra, Pamplona, Spain., Garate-Soraluze E; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain., Berraondo P; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Perez-Gracia JL; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Department of Medical Oncology, Universidad de Navarra, Pamplona, Spain., de Andrea CE; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.; Department of Anatomy, Physiology and Pathology, Universidad de Navarra, Pamplona, Spain., Rodriguez-Ruiz ME; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain., Melero I; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IDISNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Sep 13; Vol. 30 (18), pp. 4131-4142.

Dietary-Based Diabetes Risk Score and breast cancer: a prospective evaluation in the SUN project.

Autor: Aguilera-Buenosvinos I; Universidad de Navarra Departamento de Medicina Preventiva y Salud Pública, Pamplona, 31008, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, 31008, Spain., Martínez-González MA; Universidad de Navarra Departamento de Medicina Preventiva y Salud Pública, Pamplona, 31008, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, 31008, Spain.; Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), Madrid, 28029, Spain.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA., Romanos-Nanclares A; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sánchez-Bayona R; Universidad de Navarra Departamento de Medicina Preventiva y Salud Pública, Pamplona, 31008, Spain.; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain., de Andrea CE; IdiSNA, Navarra Institute for Health Research, Pamplona, 31008, Spain.; Department of Pathology, Clinica Universidad de Navarra, Pamplona, Navarra, 31008, Spain.; Centro de Investigación Biomédica en Red, Área de Cáncer, Madrid, 28029, Spain., Domínguez LJ; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.; Faculty of Medicine and Surgery, University of Enna 'Kore', Enna, Italy., Toledo E; Universidad de Navarra Departamento de Medicina Preventiva y Salud Pública, Pamplona, 31008, Spain. etoledo@unav.es.; IdiSNA, Navarra Institute for Health Research, Pamplona, 31008, Spain. etoledo@unav.es.; Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), Madrid, 28029, Spain. etoledo@unav.es.

Publikováno v: Journal of physiology and biochemistry [J Physiol Biochem] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.

Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities.

Autor: Lopez Janeiro A; IdiSNA, Pamplona, Spain.; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain., Miraval Wong E; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain., Jiménez-Sánchez D; Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Ortiz de Solorzano C; Program of Biomedical Engineering, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain., Lozano MD; IdiSNA, Pamplona, Spain.; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Teijeira A; IdiSNA, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; CIMA, Immunology and Immunotherpay, Universidad de Navarra, Pamplona, Spain., Schalper KA; Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Melero I; IdiSNA, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; CIMA, Immunology and Immunotherpay, Universidad de Navarra, Pamplona, Spain.; Nuffield Department of Medicine, Oxford University, Oxford, UK., De Andrea CE; IdiSNA, Pamplona, Spain ceandrea@unav.es.; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 May 31; Vol. 12 (5). Date of Electronic Publication: 2024 May 31.

Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.

Autor: Weeratunga P; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Denney L; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK., Repapi E; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Sergeant M; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Etherington R; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Vuppussetty C; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Turner GDH; Department of Cellular Pathology and Radcliffe Department of Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Clelland C; Anatomic Pathology, Weill Cornell Medical College, Doha, Qatar., Woo J; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Cross A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Issa F; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., de Andrea CE; Navarra Institute for Health Research, Pamplona, Spain., Melero Bermejo I; Navarra Institute for Health Research, Pamplona, Spain., Sims D; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., McGowan S; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Zurke YX; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Ahern DJ; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Gamez EC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Whalley J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Richards D; Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Diseases, University of Oxford, Oxford, UK., Klenerman P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Monaco C; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Udalova IA; Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK., Dong T; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Antanaviciute A; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Ogg G; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Knight JC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Byrne HM; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Taylor S; MRC WIMM Computational Biology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Stephen.Taylor@well.ox.ac.uk.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Stephen.Taylor@well.ox.ac.uk., Ho LP; MRC Translational Immunology Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.; Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 08; Vol. 14 (1), pp. 7216. Date of Electronic Publication: 2023 Nov 08.

Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.

Autor: Nassiri F; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Patil V; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Yefet LS; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Singh O; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Liu J; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Dang RMA; Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA., Yamaguchi TN; Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA., Daras M; Division of Neuro-oncology, University of California San Francisco, San Francisco, CA, USA., Cloughesy TF; UCLA Neuro-Oncology Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Colman H; Huntsman Cancer Institute and Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA., Kumthekar PU; Department of Neurology, Division of Neuro-Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chen CC; Department of Neurosurgery, University of Minnesota, Minneapolis, MI, USA., Aiken R; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA., Groves MD; Department of Neurology, Texas Oncology, Austin, TX, USA., Ong SS; Division of Neuro-Oncology, Department of Neurology, the Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Ramakrishna R; Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA., Vogelbaum MA; Department of Neuro-Oncology, Neuro-Oncology Program, Moffitt Cancer Center, Tampa, FL, USA., Khagi S; Division of Medical Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kaley T; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Melear JM; Department of Internal Medicine, Baylor University Medical Center, Dallas, TX, USA., Peereboom DM; The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA., Rodriguez A; Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AK, USA., Yankelevich M; Department of Pediatrics, University of Michigan, Ann Arbor Beaumont Children's Hospital, Royal Oak, MI, USA., Nair SG; Lehigh Valley Topper Cancer Institute, Allentown, PA, USA., Puduvalli VK; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Aldape K; Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA., Gao A; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada., López-Janeiro Á; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdISNA), Pamplona, Spain., de Andrea CE; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdISNA), Pamplona, Spain., Alonso MM; Navarra Institute for Health Research (IdISNA), Pamplona, Spain.; Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.; Program of Solid Tumors, Center for the Applied Medical Research (CIMA), Pamplona, Spain., Boutros P; Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA., Robbins J; DNATrix Inc., Carlsbad, CA, USA., Mason WP; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Sonabend AM; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Stupp R; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Medicine, Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Fueyo J; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gomez-Manzano C; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lang FF; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zadeh G; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada. gelareh.zadeh@uhn.ca.; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada. gelareh.zadeh@uhn.ca.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. gelareh.zadeh@uhn.ca.

Publikováno v: Nature medicine [Nat Med] 2023 Jun; Vol. 29 (6), pp. 1370-1378. Date of Electronic Publication: 2023 May 15.