Zobrazeno 1 - 10
of 178
pro vyhledávání: '"De‐shen Wang"'
Autor:
Zi-Jing Li, William Pat Fong, Dong-Sheng Zhang, Hui-Yan Luo, Dong-Liang Chen, Yan-Yu Cai, Zhi-Gang Chen, Jian-Li Duan, Zi-Yao Huang, Yu-Ting Lu, Xiao-Xia Huang, Yu-Hong Li, De-Shen Wang
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and safety of ALK inhibitors (ALKi)
Externí odkaz:
https://doaj.org/article/bbdc714779f84f3980277043828d8a35
Autor:
De-Shen Wang, Chao Ren, Shan-Shan Li, William Pat Fong, Xiao-Jun Wu, Jian Xiao, Bin-Kui Li, Yun Zheng, Pei-Rong Ding, Gong Chen, Miao-Zhen Qiu, Zhi-Qiang Wang, Feng-Hua Wang, Hui-Yan Luo, Feng Wang, Xiao-Zhong Wang, Ling-Yun Wang, De-Jin Xie, Tao Chen, Li-Ren Li, Zhen-Hai Lu, Xiao-Hui Zhai, Tian-Shu Liu, Ying Yuan, Jia-Qi Chen, Qiong Tan, Zhi-Zhong Pan, De-Sen Wan, Rong Zhang, Yun-Fei Yuan, Rui-Hua Xu, Yu-Hong Li
Publikováno v:
PLoS Medicine, Vol 21, Iss 5, p e1004389 (2024)
BackgroundIt remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes in a cohort of RAS/BRAF wild-type colorectal cancer (CRC) patients with initially unresectable colorec
Externí odkaz:
https://doaj.org/article/b9e6a45661f549378ef2d8ab851edf5e
Autor:
Renjing Zhang, Yang Yang, Chunfang Hu, Mayan Huang, Wenjian Cen, Dongyi Ling, Yakang Long, Xin-Hua Yang, Boheng Xu, Junling Peng, Sujie Wang, Weijie Zhu, Mingbiao Wei, Jiaojiao Yang, Yuxia Xu, Xu Zhang, Jiangjun Ma, Fang Wang, Hongtu Zhang, Peiqing Ma, Xiaojun Zhu, Guohui Song, Li-Yue Sun, De-Shen Wang, Feng-Hua Wang, Yu-Hong Li, Sandro Santagata, Qin Li, Yan-Fen Feng, Ziming Du
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Solitary fibrous tumors (SFTs) are rare mesenchymal tumors with unpredictable evolution and with a recurrence or metastasis rate of 10-40%. Current medical treatments for relapsed SFTs remain ineffective. Here, we identify potential therapeu
Externí odkaz:
https://doaj.org/article/40b85ffd685f4b10bbdd4c6df9fa3b0a
Autor:
Zhi-Gang Chen, Xiao-Meng Ji, Yu-Xia Xu, William Pat Fong, Xiao-Yun Liu, Jie-Ying Liang, Qiong Tan, Lei Wen, Yan-Yu Cai, De-Shen Wang, Yu-Hong Li
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Patients with initially unresectable colorectal cancer liver metastases (IU-CRLM) might benefit from using an effective systemic treatment followed by resection of liver metastases but the curative success rate is quite low. Indeed, nearl
Externí odkaz:
https://doaj.org/article/ccaf6294ee4a4f3d94a0190ab3a31533
Autor:
Zi-Yao Huang, Lei Wen, Liu-Fang Ye, Yu-Ting Lu, William Pat Fong, Ren-Jing Zhang, Si-Xian Wu, Zhi-Gang Chen, Yan-Yu Cai, Rui-Hua Xu, Yu-Hong Li, Zi-Ming Du, De-Shen Wang
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Transmembrane E3 ubiquitin ligase ( RNF43 ) mutations are present in approximately 6–18% of colorectal cancers (CRC) and could enhance Wnt/β-catenin signaling, which is emerging as a promising therapeutic target. This study aims to inv
Externí odkaz:
https://doaj.org/article/d267fbf1f23c40f6a8146f578616f919
Autor:
Lin Qi, Jie-ying Liang, Zhong-wu Li, Shao-yan Xi, Yu-ni Lai, Feng Gao, Xian-rui Zhang, De-shen Wang, Ming-tao Hu, Yi Cao, Li-jian Xu, Ronald C.K. Chan, Bao-cai Xing, Xin Wang, Yu-hong Li
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107702- (2023)
Summary: Histopathological images of colorectal liver metastases (CRLM) contain rich morphometric information that may predict patients’ outcomes. However, to our knowledge, no study has reported any practical deep learning framework based on the h
Externí odkaz:
https://doaj.org/article/c8d3833bb8cc4a3398c7f127be17b06d
Autor:
Jia Bo Zheng, Chau Wei Wong, Jia Liu, Xiao-Jing Luo, Wei-Yi Zhou, Yan-Xing Chen, Hui-Yan Luo, Zhao-Lei Zeng, Chao Ren, Xiao-Ming Xie, De-Shen Wang
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Metabolic inhibition via PFKFB3 inhibition has demonstrated considerable tumor inhibitory effects in various studies; however, PFKFB3 inhibition did not show satisfactory tumor inhibition when used in clinical trials. PFKFB3 is a crucial metabolic en
Externí odkaz:
https://doaj.org/article/b4d989c05a9e4ef98ddde92d7134dfe5
Autor:
Long Bai, Ze‐Yu Lin, Yun‐Xin Lu, Qin Chen, Han Zhou, Qi Meng, Chun‐Ping Lin, Wan‐Lan Huang, Yun‐Le Wan, Zhi‐Zhong Pan, De‐Shen Wang
Publikováno v:
Cancer Medicine, Vol 10, Iss 22, Pp 8005-8019 (2021)
Abstract Background The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between nonmetastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of cu
Externí odkaz:
https://doaj.org/article/379bb3dd7c62469a931ce8bb0e4b0198
Autor:
Jie‐ying Liang, Hao‐cheng Lin, Jingwen Liu, De‐shen Wang, Yun‐fei Yuan, Bin‐kui Li, Yun Zheng, Xiao‐jun Wu, Gong Chen, Feng‐hua Wang, Zhi‐qiang Wang, Zhi‐zhong Pan, De‐sen Wan, Rui‐hua Xu, Yu‐hong Li
Publikováno v:
Cancer Medicine, Vol 10, Iss 5, Pp 1535-1544 (2021)
Abstract Purpose We aimed to construct a nomogram to predict personalized post‐recurrence survival (PRS) among colorectal cancer liver metastasis (CRLM) patients with post‐hepatectomy recurrence. Methods Colorectal cancer liver metastasis patient
Externí odkaz:
https://doaj.org/article/56529d912d8c428d85751d478f15c9bd
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-19 (2020)
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and
Externí odkaz:
https://doaj.org/article/d632b21718e94b679d98a2fde221e564